KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient.

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:The interaction between four fluoroquinolones (ciprofloxacin, norfloxacin, pefloxacin, and ofloxacin) and biofilms of Pseudomonas aeruginosa in wells of microtiter plates and on segments of vascular catheters were studied in an in vitro model of vascular catheter colonization. Subinhibitory concentrations (one-half, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Yassien M,Khardori N,Ahmedy A,Toama M

更新日期：1995-10-01 00:00:00

abstract：:Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike Fe(3+), Ga(3+) canno...

journal_title：Antimicrobial agents and chemotherapy

authors： Olakanmi O,Kesavalu B,Pasula R,Abdalla MY,Schlesinger LS,Britigan BE

更新日期：2013-12-01 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:The DNA sequences of two plasmids carrying vanA, pVEF1 (39,626 bp) and pVEF2 (39,714 bp), were determined. Forty-three shared coding sequences were identified, and the only nucleotide difference was an 88-bp indel. A postsegregational killing system was identified. This system possibly explains the persistence of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sletvold H,Johnsen PJ,Simonsen GS,Aasnaes B,Sundsfjord A,Nielsen KM

更新日期：2007-02-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming ...

journal_title：Antimicrobial agents and chemotherapy

authors： D'Souza R,Pinto NA,Higgins PG,Hwang I,Yong D,Choi J,Lee K,Chong Y

更新日期：2017-04-24 00:00:00

abstract：:Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+...

journal_title：Antimicrobial agents and chemotherapy

authors： Bermudez LE,Inderlied CB,Kolonoski P,Chee CB,Aralar P,Petrofsky M,Parman T,Green CE,Lewin AH,Ellis WY,Young LS

更新日期：2012-08-01 00:00:00

abstract：:The combination of liposomal amphotericin B (LAMB) and caspofungin (CAS) holds promise to improve the outcome of opportunistic invasive mycoses with poor prognosis. Little is known, however, about the safety and pharmacokinetics of the combination in patients at high risk for these infections. The safety and pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Silling G,Young C,Schwerdtfeger R,Ostermann H,Heinz WJ,Gerss J,Kolve H,Lanvers-Kaminsky C,Vieira Pinheiro JP,Gammelin S,Cornely OA,Wuerthwein G

更新日期：2010-10-01 00:00:00

abstract：:The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and elect...

journal_title：Antimicrobial agents and chemotherapy

authors： Thorn RM,Robinson GM,Reynolds DM

更新日期：2013-05-01 00:00:00

abstract：:beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. All strains producing a probe-type enzyme gave a positive hybridization reaction. C...

journal_title：Antimicrobial agents and chemotherapy

authors： Huovinen S,Huovinén P,Jacoby GA

更新日期：1988-02-01 00:00:00

abstract：:The in vitro activities of vancomycin and teicoplanin alone and in combination with gentamicin or tobramycin were studied by time-kill techniques with 11 strains of pathogenic diphtheroids (Corynebacterium group JK). The activities of vancomycin and teicoplanin were similar (MIC for 90% of strains tested [MIC90], 1 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Spitzer PG,Eliopoulos GM,Karchmer AW,Moellering RC Jr

更新日期：1988-04-01 00:00:00

abstract：:Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantim...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Lovelace JK,Waits VB,Hanson WL,Klayman DL

更新日期：1990-05-01 00:00:00

abstract：:Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneu...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun H,Ting L,Machineni S,Praestgaard J,Kuemmell A,Stein DS,Sunkara G,Kovacs SJ,Villano S,Tanaka SK

更新日期：2016-11-21 00:00:00

abstract：:The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173 recent clinical bite wound isolates were determined by agar dilution. Sparfloxacin was active against all strains (MIC for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1993-05-01 00:00:00

abstract：:The gram-positive bacterium Staphylococcus epidermidis is the most common cause of infections associated with catheters and other indwelling medical devices. S. epidermidis produces an extracellular slime that enables it to form adherent biofilms on plastic surfaces. We found that a biofilm-releasing enzyme produced b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaplan JB,Ragunath C,Velliyagounder K,Fine DH,Ramasubbu N

更新日期：2004-07-01 00:00:00

abstract：:Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. Twenty-seven single-plaque isolates of herpes simplex virus type 1 (HSV-1) resistant to foscarnet were selected from foscarnet- a...

journal_title：Antimicrobial agents and chemotherapy

authors： Saijo M,Suzutani T,Morikawa S,Kurane I

更新日期：2005-02-01 00:00:00

abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

更新日期：1991-03-01 00:00:00

abstract：:We tested the combined activity of vancomycin and seven beta-lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested beta-lactams exhibited an additive effect at or near their MICs, while all sh...

journal_title：Antimicrobial agents and chemotherapy

authors： Aritaka N,Hanaki H,Cui L,Hiramatsu K

更新日期：2001-04-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:Antibiotic resistance of biofilm-grown bacteria contributes to chronic infections, such as marginal and periapical periodontitis, which are strongly associated with Porphyromonas gingivalis. Concurrent azithromycin (AZM) administration and mechanical debridement improve the clinical parameters of periodontal tissue in...

journal_title：Antimicrobial agents and chemotherapy

authors： Maezono H,Noiri Y,Asahi Y,Yamaguchi M,Yamamoto R,Izutani N,Azakami H,Ebisu S

更新日期：2011-12-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

journal_title：Antimicrobial agents and chemotherapy

authors： Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

更新日期：2007-05-01 00:00:00

abstract：:The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglyce...

journal_title：Antimicrobial agents and chemotherapy

authors： Javor GT

更新日期：1983-12-01 00:00:00

abstract：:The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Naughtin M,Dyason JC,Mardy S,Sorn S,von Itzstein M,Buchy P

更新日期：2011-05-01 00:00:00

abstract：:Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 microg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2x MIC was bactericidal against all 10 pneumococci tested after 24 h. Vancomycin and teicoplanin killed 10 a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin G,Smith K,Ednie LM,Appelbaum PC

更新日期：2005-12-01 00:00:00

abstract：:The host immune response to human cytomegalovirus (HCMV) is effective against HCMV reactivation from latency, though not sufficient to clear the virus. T cells are primarily responsible for the control of viral reactivation. When the host immune system is compromised, as in transplant recipients with immunosuppression...

journal_title：Antimicrobial agents and chemotherapy

authors： Meng W,Tang A,Ye X,Gui X,Li L,Fan X,Schultz RD,Freed DC,Ha S,Wang D,Zhang N,Fu TM,An Z

更新日期：2017-12-21 00:00:00

abstract：:Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC24/MIC) of >400 as the...

journal_title：Antimicrobial agents and chemotherapy

authors： Tseng SH,Lim CP,Chen Q,Tang CC,Kong ST,Ho PC

更新日期：2018-03-27 00:00:00

abstract：:The Chinese traditional medicine mao-bushi-saishin-to (MBST), which has anti-inflammatory effects and has been used to treat the common cold and nasal allergy in Japan, was examined for its effects on the therapeutic activity of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium avium complex (MAC) infe...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu T,Tomioka H,Sato K,Sano C,Akaki T,Dekio S,Yamada Y,Kamei T,Shibata H,Higashi N

更新日期：1999-03-01 00:00:00

abstract：:SM-7338, a new carbapenem antibiotic, was demonstrated to have potent antibacterial activity against a broad spectrum of aerobes, including Staphylococcus aureus, beta-hemolytic streptococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp., members of the family Enterobacteriaceae, Pseudomonas spp., a...

journal_title：Antimicrobial agents and chemotherapy

authors： Edwards JR,Turner PJ,Wannop C,Withnell ES,Grindey AJ,Nairn K

更新日期：1989-02-01 00:00:00