Antimicrobial susceptibilities of clinical isolates of HACEK organisms.

abstract：:An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identification and characterization of two novel zinc-attenuating compounds, Z...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohrt KAO,Marín L,Kjellerup L,Clausen JD,Dalby-Brown W,Calera JA,Winther AL

更新日期：2018-04-26 00:00:00

abstract：:Boronic acid transition state inhibitors (BATSIs) with R1 side chains of cefotaxime and ceftazidime were assayed against SHV-1, SHV-2, SHV-5, D104K, and D104K G238S beta-lactamases. The D104K variant was the most susceptible to inhibition by the ceftazidime BATSI (Ki, 730+/-80 nM), while the D104K G238S variant was th...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson JM,Prati F,Bethel CR,Bonomo RA

更新日期：2007-04-01 00:00:00

abstract：:Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is...

journal_title：Antimicrobial agents and chemotherapy

authors： de Aguiar Cordeiro R,de Farias Marques FJ,de Aguiar Cordeiro R,da Silva MR,Donato Maia Malaquias A,Silva de Melo CV,Mafezoli J,Ferreira de Oliveira Mda C,Nogueira Brilhante RS,Gadelha Rocha MF,Pinheiro Gomes Bandeira Tde J,Costa Si

更新日期：2014-05-01 00:00:00

abstract：:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP50...

journal_title：Antimicrobial agents and chemotherapy

authors： Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JY

更新日期：2005-12-01 00:00:00

abstract：:Early studies of immobilized peptides mainly focused upon the relationship between structural properties and the activity of soluble and surface-tethered sequences. The intention of this study was to analyze the influence of immobilization parameters upon the activity profile of peptides. Resin beads (TentaGel S NH(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Bagheri M,Beyermann M,Dathe M

更新日期：2009-03-01 00:00:00

abstract：:Fluconazole, an inhibitor of certain human cytochrome P-450 isozymes, is used for the prevention and treatment of a broad range of fungal infections that predominantly affect immunocompromised individuals. This study evaluated the influence of fluconazole on the steady-state pharmacokinetics of delavirdine, a nonnucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Borin MT,Cox SR,Herman BD,Carel BJ,Anderson RD,Freimuth WW

更新日期：1997-09-01 00:00:00

abstract：:We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Barth N,Ribeiro VB,Zavascki AP

更新日期：2015-01-01 00:00:00

abstract：:4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-g...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimi IR,Shoukry S,Zaki Z

更新日期：1976-04-01 00:00:00

abstract：:Positive carbon-containing electrodes conveying 5 or more microA of constant direct current per cm2 showed bactericidal activity on intact back skin of 13 human subjects. This effect increased with the duration of stimulation up to a total surface bacterial kill at 20 h. When total current and current density were var...

journal_title：Antimicrobial agents and chemotherapy

authors： Bolton L,Foleno B,Means B,Petrucelli S

更新日期：1980-07-01 00:00:00

abstract：:Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DCK,Guo I,Burrows LL

更新日期：2020-02-21 00:00:00

abstract：:The discovery of antibiotics in the last century is considered one of the most important achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity and mortality associated with bacterial infections. However, inappropriate use of antibiotics has led to emergence of antibiotic resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Ghosh D,Veeraraghavan B,Elangovan R,Vivekanandan P

更新日期：2020-01-27 00:00:00

abstract：:Preclinical animal models of infection are employed to develop new agents but also to screen among molecules to rank them. There are often major differences between human pharmacokinetic (PK) profiles and those developed by animal models of infection, and these may lead to substantial differences in efficacy relative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Duncanson B,Scanga CA,Kim S,Schmidt S,Neely MN,Yamada WM,Vicchiarelli M,Peloquin CA,Louie A

更新日期：2020-11-17 00:00:00

abstract：:This study determined the pharmacokinetic disposition of cefonicid. A single dose of 7.5 mg/kg of body weight was administered to five healthy volunteers as a 5-min intravenous infusion. Multiple plasma and urine samples were collected for 48 h. Peak plasma concentrations ranged from 95 to 156 micrograms/ml and fell s...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Hatheway GJ,Gambertoglio JG,Lin ET,Conte JE Jr

更新日期：1982-06-01 00:00:00

abstract：:Cystathionine gamma-lyase (EC 4.4.1.1) was purified from Streptomyces cattleya, an actinomycete which produces the unusual beta-lactam antibiotic thienamycin. The enzyme displays broad substrate specificity and is similar to gamma-lyases purified from other microorganisms. That the gamma-lyase functions in vivo to pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Williamson JM,Meyer R,Inamine E

更新日期：1985-10-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically...

journal_title：Antimicrobial agents and chemotherapy

authors： Forrest A,Garonzik SM,Thamlikitkul V,Giamarellos-Bourboulis EJ,Paterson DL,Li J,Silveira FP,Nation RL

更新日期：2017-10-24 00:00:00

abstract：:We investigated the relationship between susceptibility to beta-lactam antibiotics and variation in the major outer membrane protein P2 (OmpP2; also called porin) of persistent nonencapsulated Haemophilus influenzae isolated from cystic fibrosis patients. Nine OmpP2 variants were selected from two distinct H. influenz...

journal_title：Antimicrobial agents and chemotherapy

authors： Regelink AG,Dahan D,Möller LV,Coulton JW,Eijk P,Van Ulsen P,Dankert J,Van Alphen L

更新日期：1999-02-01 00:00:00

abstract：:Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P...

journal_title：Antimicrobial agents and chemotherapy

authors： Cascio A,Di Liberto C,D'Angelo M,Iaria C,Scarlata F,Titone L,Campisi G

更新日期：2004-07-01 00:00:00

abstract：:The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

journal_title：Antimicrobial agents and chemotherapy

authors： Fick RB Jr,Alexander MR,Prince RA,Kasik JE

更新日期：1987-05-01 00:00:00

abstract：:Human cryptococcosis can occur as a primary or opportunistic infection and develops as an acute, subacute, or chronic systemic infection involving different organs of the host. Given the limited therapeutic options and the occasional resistance to fluconazole, there is a need to develop novel drugs for the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sá NP,Lima CM,Lino CI,Barbeira PJS,Baltazar LM,Santos DA,Oliveira RB,Mylonakis E,Fuchs BB,Johann S

更新日期：2017-07-25 00:00:00

abstract：:Within wounds, microorganisms predominantly exist as biofilms. Biofilms are associated with chronic infections and represent a tremendous clinical challenge. As antibiotics are often ineffective against biofilms, use of dispersal agents as adjunctive, topical therapies for the treatment of wound infections involving b...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanchez CJ Jr,Akers KS,Romano DR,Woodbury RL,Hardy SK,Murray CK,Wenke JC

更新日期：2014-08-01 00:00:00

abstract：:Bloodstream infection (BSI) due to multidrug-resistant Klebsiella is associated with high rates of morbidity and mortality. The aim of this study was to identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Anderson DJ,Engemann JJ,Harrell LJ,Carmeli Y,Reller LB,Kaye KS

更新日期：2006-05-01 00:00:00

abstract：:Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C...

journal_title：Antimicrobial agents and chemotherapy

authors： Liston SD,Whitesell L,Kapoor M,Shaw KJ,Cowen LE

更新日期：2020-04-21 00:00:00

abstract：:We evaluated the antituberculosis (anti-TB) activity of five β-lactams alone or in combination with β-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent an...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Maeda S,Kazumi Y,Doi N

更新日期：2014-11-01 00:00:00

abstract：:Strains of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 (DT104) and S. enterica serovar Agona (Agona) have been found to harbor Salmonella genomic island 1 (SGI1), a 43-kb genomic region that contains many of the drug resistance genes. Such strains are resistant to ampicillin (pse-1), chlorampheni...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd D,Cloeckaert A,Chaslus-Dancla E,Mulvey MR

更新日期：2002-06-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:Chronic airway infection and inflammation contribute to the progressive loss of lung function and shortened survival of patients with cystic fibrosis (CF). Rhesus theta defensin-1 (RTD-1) is a macrocyclic host defense peptide with antimicrobial and immunomodulatory activities. Combined with favorable preclinical safet...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Jayne JG,Sun M,Kimura E,Meinert J,Wang JC,Schaal JB,Tran D,Rao AP,Akbari O,Selsted ME,Beringer PM

更新日期：2017-07-25 00:00:00

abstract：:Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahn J,Ko A,Jun EJ,Won M,Kim YK,Ju ES,Jeon ES,Lee H

更新日期：2012-07-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a life-threatening infection in lung transplant recipients; however, no studies of the pharmacokinetics and pharmacodynamics (PKPD) of echinocandins in transplanted lungs have been reported. We conducted a single-dose prospective study of the intrapulmonary and plasma PKPD of 150 mg...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Goutelle S,Jelliffe RW,Golden JA,Little EA,DeVoe C,Mickiene D,Hayes M,Conte JE Jr

更新日期：2010-08-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:The outer membrane permeability to meropenem and imipenem in Escherichia coli K-12 was investigated, and its porin-deficient mutants were transformed with a constructed vector carrying the carbapenem-hydrolyzing CphA metallo-beta-lactamase gene. By using the method of Zimmermann and Rosselet, meropenem was shown to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Cornaglia G,Guan L,Fontana R,Satta G

更新日期：1992-09-01 00:00:00