Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides.

abstract：:Candida glabrata, the second most common cause of Candida infections, is associated with high rates of mortality and often exhibits resistance to the azole class of antifungal agents. Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding ...

journal_title：Antimicrobial agents and chemotherapy

authors： Whaley SG,Caudle KE,Vermitsky JP,Chadwick SG,Toner G,Barker KS,Gygax SE,Rogers PD

更新日期：2014-08-01 00:00:00

abstract：:Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： He R,Yang Y,Wu Y,Zhong LL,Yang Y,Chen G,Qin M,Liang X,Ahmed MAEE,Lin M,Yan B,Xia Y,Dai M,Chen H,Tian GB

更新日期：2021-01-20 00:00:00

abstract：:Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaka M,Jaturapat A,Kramyu J,Tanticharoen M,Thebtaranonth Y

更新日期：2002-04-01 00:00:00

abstract：:Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal structure of the larg...

journal_title：Antimicrobial agents and chemotherapy

authors： Berisio R,Corti N,Pfister P,Yonath A,Böttger EC

更新日期：2006-11-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:Vancomycin pharmacokinetics were studied in four patients with peritonitis undergoing chronic intermittent peritoneal dialysis. Serum levels exceeding 4.0 micrograms/ml were maintained for 8 and 13 days after a single 1-g intravenous dose. Vancomycin serum concentrations measured before, during, and upon completion of...

journal_title：Antimicrobial agents and chemotherapy

authors： Magera BE,Arroyo JC,Rosansky SJ,Postic B

更新日期：1983-05-01 00:00:00

abstract：:We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. The degree of potentiation as estimated by standard isobolar...

journal_title：Antimicrobial agents and chemotherapy

authors： Winter RW,Cornell KA,Johnson LL,Ignatushchenko M,Hinrichs DJ,Riscoe MK

更新日期：1996-06-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we report the discovery of a novel class of HCV polymerase nonnucleoside...

journal_title：Antimicrobial agents and chemotherapy

authors： Nyanguile O,Pauwels F,Van den Broeck W,Boutton CW,Quirynen L,Ivens T,van der Helm L,Vandercruyssen G,Mostmans W,Delouvroy F,Dehertogh P,Cummings MD,Bonfanti JF,Simmen KA,Raboisson P

更新日期：2008-12-01 00:00:00

abstract：:BAL5788 is the water-soluble prodrug of BAL9141, a novel broad-spectrum cephalosporin with potent bactericidal activities against methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae. We investigated the safety and pharmacokinetics of BAL5788 in a double-blind, single-as...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt-Hoffmann A,Roos B,Schleimer M,Sauer J,Man A,Nashed N,Brown T,Perez A,Weidekamm E,Kovács P

更新日期：2004-07-01 00:00:00

abstract：:Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Schnitzler P,Koch C,Reichling J

更新日期：2007-05-01 00:00:00

abstract：:Multiple injections of ofloxacin (subcutaneous or oral) in combination with a Lactobacillus casei preparation, LC9018 (subcutaneous), in mice infected intravenously with Mycobacterium fortuitum led to a marked delay in the incidence of spinning disease, a lowered incidence of gross renal lesions, and an increase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Sato K,Saito H

更新日期：1990-04-01 00:00:00

abstract：:SDZ MRL 953, a new synthetic monosaccharidic lipid A, was investigated in vitro and in vivo for immunopharmacological activities. In experimental models of microbial infections, the compound was highly protective when it was administered prophylactically either once or three times to myelosuppressed or immunocompetent...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam C,Schütze E,Hildebrandt J,Aschauer H,Liehl E,Macher I,Stütz P

更新日期：1991-03-01 00:00:00

abstract：:A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also de...

journal_title：Antimicrobial agents and chemotherapy

authors： Avanzi C,Maia RC,Benjak A,Nery JA,Sales AM,Miranda A,Duppre NC,Nogueira Brum Fontes A,Pereira da Silva T,Olmo Pinheiro R,Neves-Manta F,Moreira SJM,Busso P,Sarno EN,Suffys PN,Cole ST,Moraes MO

更新日期：2020-06-23 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:Cefamandole has a broader spectrum and greater potency than the other cephalosporins. It includes Haemophilus influenzae, most strains of Enterobacter, and many strains of indole-positive Proteus and Bacteroides, with a lower minimal inhibitory concentration for Escherichia coli, Klebsiella, etc. Concentrations of dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Griffith RS,Black HR,Brier GL,Wolny JD

更新日期：1976-11-01 00:00:00

abstract：:The responses of 20 ampicillin-susceptible Haemophilus influenzae type b clinical isolates to the bactericidal action of ampicillin were studied by using a modified agar dilution plate count method. A well-defined paradoxical effect was observed in each of the 24-h killing curve patterns for 19 of the 20 isolates, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Woolfrey BF,Gresser-Burns ME,Lally RT

更新日期：1987-11-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a life-threatening disease of immunocompromised patients that requires aggressive therapy. Detection of the disease and monitoring of the therapeutic response during IPA are complex, and current molecular diagnostics are not suitably robust. Here, we explored proteomic profile...

journal_title：Antimicrobial agents and chemotherapy

authors： Krel M,Petraitis V,Petraitiene R,Jain MR,Zhao Y,Li H,Walsh TJ,Perlin DS

更新日期：2014-06-01 00:00:00

abstract：:The present population pharmacokinetic (PK) and pharmacodynamic (PD) study modeled the effects of covariates including drug adherence and the coadministration of protease inhibitors (PIs) on the pharmacokinetics of efavirenz (EFV) and the relationship between EFV exposure and virological failure in patients who failed...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfister M,Labbé L,Hammer SM,Mellors J,Bennett KK,Rosenkranz S,Sheiner LB,Adult AIDS Clinical Trial Group Study 398.

更新日期：2003-01-01 00:00:00

abstract：:The in vitro activities of LY146032 and seven comparative antimicrobial agents against 14 species of staphylococci, streptococci, and enterococci were studied. MICs of LY146032 were less than or equal to 0.5 microgram/ml for all staphylococci, including oxacillin-resistant strains; less than or equal to 0.25 microgram...

journal_title：Antimicrobial agents and chemotherapy

authors： Fass RJ,Helsel VL

更新日期：1986-11-01 00:00:00

abstract：:TEM-24 remains one of the most widespread TEM-type extended-spectrum beta-lactamases (ESBLs) among Enterobacteriaceae. To analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative TEM-24 producers from Belgium, France, Portugal, and Spain (1...

journal_title：Antimicrobial agents and chemotherapy

authors： Novais A,Baquero F,Machado E,Cantón R,Peixe L,Coque TM

更新日期：2010-02-01 00:00:00

abstract：:The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellos-Bourboulis EJ,Karnesis L,Galani I,Giamarellou H

更新日期：2002-12-01 00:00:00

abstract：:Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure of A. flavus to subinhibitory concentrations of VRC in vitro cau...

journal_title：Antimicrobial agents and chemotherapy

authors： Ukai Y,Kuroiwa M,Kurihara N,Naruse H,Homma T,Maki H,Naito A

更新日期：2018-10-24 00:00:00

abstract：:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia...

journal_title：Antimicrobial agents and chemotherapy

authors： Ocampo AM,Chen L,Cienfuegos AV,Roncancio G,Chavda KD,Kreiswirth BN,Jiménez JN

更新日期：2015-10-26 00:00:00

abstract：:The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

journal_title：Antimicrobial agents and chemotherapy

authors： Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

更新日期：2013-02-01 00:00:00

abstract：:A method utilizing immobilized major group rhinoviruses and biotinylated soluble intercellular adhesion molecule 1 has been developed for the detection of capsid binders. Binding measurements indicate a loss in relative affinity of biotinylated soluble intercellular adhesion molecule 1 for rhinoviruses by capsid binde...

journal_title：Antimicrobial agents and chemotherapy

authors： Last-Barney K,Marlin SD,Pal K,Cahill-Feehan C,McNally EJ,Jeanfavre DD,Merluzzi VJ

更新日期：1993-08-01 00:00:00

abstract：:The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak co...

journal_title：Antimicrobial agents and chemotherapy

authors： Pradines B,Tall A,Fusai T,Spiegel A,Hienne R,Rogier C,Trape JF,Le Bras J,Parzy D

更新日期：1999-02-01 00:00:00

abstract：:A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Segatore B,De Massis MR,Franceschini N,Bianchi C,Rossolini GM,Amicosante G

更新日期：2002-03-01 00:00:00

abstract：:Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

更新日期：2019-02-26 00:00:00

abstract：:Mice infected with Plasmodium berghei served as donors of erythrocytes with a high level of parasitemia for the study of ferriprotoporphyrin IX (FP) polymerization. Six hours after treatment of these mice with 3 micromol of chloroquine per 25 g of body weight, there were significant losses of heme polymerase I (HPA I)...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitch CD,Chou AC

更新日期：1997-11-01 00:00:00