Interaction of metronidazole with resistant and susceptible Bacteroides fragilis.

abstract：:The vesicular stomatitis virus cytopathic effect reduction assay is suitable to quantify polyethylene glycol-alpha interferon 2a (PEG-IFN-alpha 2a) and PEG-IFN-alpha 2b. Human serum and ribavirin did not interfere with the assay. This bioassay was successfully used for assaying PEG-IFN-alpha 2a and PEG-IFN-alpha 2b in...

journal_title：Antimicrobial agents and chemotherapy

authors： Boulestin A,Kamar N,Legrand-Abravanel F,Sandres-Saune K,Alric L,Vinel JP,Rostaing L,Izopet J

更新日期：2004-09-01 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in comparison w...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams GC,Liu A,Knipp G,Sinko PJ

更新日期：2002-11-01 00:00:00

abstract：:A new 3-N-aminoglycoside acetyltransferase is described, which possesses a wider substrate range than any such enzyme so far discovered in clinical isolates of antibiotic-resistant bacteria. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Biddlecome S,Haas M,Davies J,Miller GH,Rane DF,Daniels PJ

更新日期：1976-06-01 00:00:00

abstract：:Grazoprevir (GZR) plus elbasvir is an approved treatment for chronic infection with hepatitis C virus (HCV) genotype 1 or 4. HCV infection complications include liver cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The objective of this study was to evaluate the pharmacokinetics and safety of multipl...

journal_title：Antimicrobial agents and chemotherapy

authors： Caro L,Wenning L,Guo Z,Fraser IP,Fandozzi C,Talaty J,Panebianco D,Ho M,Uemura N,Reitmann C,Angus P,Gane E,Marbury T,Smith WB,Iwamoto M,Butterton JR,Yeh WW

更新日期：2017-11-22 00:00:00

abstract：:Despite the development of novel antibiotics active against Gram-positive bacteria, vancomycin generally remains the first treatment, although rapidly achieving concentrations associated with maximal efficacy provides an unresolved challenge. The objective of this study was to conduct a population pharmacokinetic anal...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts JA,Taccone FS,Udy AA,Vincent JL,Jacobs F,Lipman J

更新日期：2011-06-01 00:00:00

abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

journal_title：Antimicrobial agents and chemotherapy

authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

更新日期：2010-03-01 00:00:00

abstract：:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen Pseudomonas aeruginosa in the presence of the glycoprotein mucin, which is found in high abundance at mucosal surfaces, especially those of the lungs of cystic fibrosis and bronchiectasis patients. Here, we investigated the ada...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun E,Gill EE,Falsafi R,Yeung A,Liu S,Hancock REW

更新日期：2018-08-27 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achieva...

journal_title：Antimicrobial agents and chemotherapy

authors： Li Y,Nguyen MH,Derendorf H,Cheng S,Clancy CJ

更新日期：2007-08-01 00:00:00

abstract：:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

更新日期：2017-08-24 00:00:00

abstract：:Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macropha...

journal_title：Antimicrobial agents and chemotherapy

authors： Lokensgard JR,Gekker G,Hu S,Arthur AF,Chao CC,Peterson PK

更新日期：1997-11-01 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:The Bacteroides fragilis bacteriocin which inhibits ribonucleic acid (RNA) polymerase activity had a narrow activity spectrum in vivo and only inhibited the growth of certain B. fragilis strains. In vitro the bacteriocin was not specific and inhibited RNA polymerases from widely diverse bacterial genera. RNA polymeras...

journal_title：Antimicrobial agents and chemotherapy

authors： Mossie KG,Robb FT,Jones DT,Woods DR

更新日期：1981-10-01 00:00:00

abstract：:Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Ropp PA,Hu M,Olesky M,Nicholas RA

更新日期：2002-03-01 00:00:00

abstract：:Previous studies showed an increased prevalence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) thumb subdomain polymorphisms Pro272, Arg277, and Thr286 in patients failing therapy with nucleoside analogue combinations. Interestingly, wild-type HIV-1(BH10) RT contains Pro272, Arg277, and Thr2...

journal_title：Antimicrobial agents and chemotherapy

authors： Betancor G,Puertas MC,Nevot M,Garriga C,Martínez MA,Martinez-Picado J,Menéndez-Arias L

更新日期：2010-11-01 00:00:00

abstract：:Pneumonia occurring outside of the hospital setting has traditionally been categorized as community-acquired pneumonia (CAP). However, when pneumonia is associated with health care risk factors (prior hospitalization, dialysis, residing in a nursing home, immunocompromised state), it is now more appropriately classifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Kollef KE,Reichley RM,Roubinian N,Kollef MH

更新日期：2007-10-01 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain and is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in Campylobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Luangtongkum T,Shen Z,Seng VW,Sahin O,Jeon B,Liu P,Zhang Q

更新日期：2012-03-01 00:00:00

abstract：:The in vivo and in vitro determination of significant intracellular stavudine (d4T) triphosphate (d4TTP) concentrations in human immunodeficiency virus (HIV)-infected subjects and NS-1 cells treated with zidovudine (ZDV) has recently been reported. This study was conducted to corroborate these findings with in vivo sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Meléndez M,Blanco R,Delgado W,García R,Santana J,García H,Rosario O,Rodríguez JF

更新日期：2006-03-01 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:As a relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established, nelfinavir pharmacokinetics was investigated in order to optimize the individual treatment schedule in a pediatric population. A population pharmacokinetic model was developed to describe the concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirt D,Urien S,Jullien V,Firtion G,Rey E,Pons G,Blanche S,Treluyer JM

更新日期：2006-03-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:An increase in the number of tuberculosis cases caused by multiple-drug-resistant strains of Mycobacterium tuberculosis has stimulated search for new antituberculous agents. Beta-lactam antibiotics, traditionally regarded as ineffective against tuberculosis, merit consideration. Four major penicillin-binding proteins ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Moreau D,Yajko D,Miick C,Wagner C,Hackbarth C,Kocagöz S,Rosenberg E,Hadley WK,Nikaido H

更新日期：1995-12-01 00:00:00

abstract：:The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic qui...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirai K,Aoyama H,Irikura T,Iyobe S,Mitsuhashi S

更新日期：1986-03-01 00:00:00

abstract：:Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 microg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2x MIC was bactericidal against all 10 pneumococci tested after 24 h. Vancomycin and teicoplanin killed 10 a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin G,Smith K,Ednie LM,Appelbaum PC

更新日期：2005-12-01 00:00:00

abstract：:The in vitro activities of two new antimicrobial agents, apalcillin and cefpiramide (SM-1652), were evaluated against 324 strains of anaerobic bacteria. Apalcillin (a penicillin derivative) and cefpiramide (a semisynthetic cephalosporin) were compared with piperacillin, moxalactam, and cefoxitin. Organisms studied inc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler H,Carter WT,Harris B,Finegold SM

更新日期：1984-02-01 00:00:00

abstract：:We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantón E,Pemán J,Valentín A,Espinel-Ingroff A,Gobernado M

更新日期：2009-07-01 00:00:00

abstract：:An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and bla(CTX-M-2) was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5'-conserved segment (5'-CS) and 3'-CS1 region...

journal_title：Antimicrobial agents and chemotherapy

authors： Valverde A,Cantón R,Galán JC,Nordmann P,Baquero F,Coque TM

更新日期：2006-02-01 00:00:00

abstract：:Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

journal_title：Antimicrobial agents and chemotherapy

authors： Schindler PR,Teuber M

更新日期：1975-07-01 00:00:00