Vancomycin and ceftazidime bioactivities persist for at least 2 weeks in the lumen in ports: simplifying treatment of port-associated bloodstream infections by using the antibiotic lock technique.

abstract：:Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosin...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Helgstrand E,Johansson NG,Larsson A,Misiorny A,Norén JO,Philipson L,Stenberg K,Stening G,Stridh S,Oberg B

更新日期：1977-06-01 00:00:00

abstract：:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G

更新日期：2004-10-01 00:00:00

abstract：:The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Sánchez A,Palau ML,Gómez M,Picazo JJ

更新日期：2001-08-01 00:00:00

abstract：:The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fletcher CV,Collier AC,Rhame FS,Bennett D,Para MF,Beatty CC,Jones CE,Balfour HH Jr

更新日期：1994-03-01 00:00:00

abstract：:Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

更新日期：2014-10-01 00:00:00

abstract：:The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hobbie SN,Pfister P,Brüll C,Westhof E,Böttger EC

更新日期：2005-12-01 00:00:00

abstract：:In vitro susceptibilities to 45 antibiotics were determined for 30 genetically and geographically diverse strains of Yersinia pestis by the broth microdilution method at two temperatures, 28°C and 35°C, following Clinical and Laboratory Standards Institute (CLSI) methods. The Y. pestis strains demonstrated susceptibil...

journal_title：Antimicrobial agents and chemotherapy

authors： Heine HS,Hershfield J,Marchand C,Miller L,Halasohoris S,Purcell BK,Worsham PL

更新日期：2015-04-01 00:00:00

abstract：:Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. O...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhai B,Wu C,Wang L,Sachs MS,Lin X

更新日期：2012-07-01 00:00:00

abstract：:BAL fluid samples from critically ill patients shared a rate of 29% false-positive galactomannan results. We aimed to determine whether Candida species abundance in BAL fluid causes galactomannan (GM) positivity. A total of 89 Candida culture-positive BAL fluid samples from patients without suspicion of invasive asper...

journal_title：Antimicrobial agents and chemotherapy

authors： Aigner M,Wanner M,Kreidl P,Lass-Flörl C,Lackner M

更新日期：2019-05-24 00:00:00

abstract：:Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to...

journal_title：Antimicrobial agents and chemotherapy

authors： Moyo S,Haldorsen B,Aboud S,Blomberg B,Maselle SY,Sundsfjord A,Langeland N,Samuelsen Ø

更新日期：2015-01-01 00:00:00

abstract：:ICESp1116, responsible for erm(B)-mediated, inducible erythromycin resistance in Streptococcus pyogenes, was comprehensively characterized, and its chromosomal integration site was determined. It displayed a unique mosaic organization consisting of a scaffold, related to TnGallo1 from Streptococcus gallolyticus, with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Tiberi E,Morici E,Oryasin E,Giovanetti E,Varaldo PE

更新日期：2012-12-01 00:00:00

abstract：:Southeast Asia (the Thailand-Cambodia border) has been considered the primal epicenter for most antimalarial drug resistance; however, numerous molecular epidemiological studies have successively reported multiple independent origins of sulfadoxine-pyrimethamine (SP) resistance-associated Plasmodium falciparum dhfr (p...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Yan H,Wei G,Han S,Huang Y,Zhang Q,Pan W

更新日期：2014-01-01 00:00:00

abstract：:Due to the rise of antibiotic resistance and the small number of effective antiviral drugs, new approaches for treating infectious diseases are urgently needed. Identifying targets for host-based therapies represents an emerging strategy for drug discovery. The ubiquitin-proteasome system is a central mode of signalin...

journal_title：Antimicrobial agents and chemotherapy

authors： Passalacqua KD,Charbonneau ME,Donato NJ,Showalter HD,Sun D,Wen B,He M,Sun H,O'Riordan MX,Wobus CE

更新日期：2016-06-20 00:00:00

abstract：:Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids...

journal_title：Antimicrobial agents and chemotherapy

authors： Brouwer MSM,Tehrani KHME,Rapallini M,Geurts Y,Kant A,Harders F,Mashayekhi V,Martin NI,Bossers A,Mevius DJ,Wit B,Veldman KT

更新日期：2019-05-24 00:00:00

abstract：:In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang M,Jacoby GA,Mills DM,Hooper DC

更新日期：2009-02-01 00:00:00

abstract：:Chromosomally mediated penicillin resistance in Neisseria gonorrhoeae occurs in part through alterations in penicillin-binding proteins (PBPs) and a decrease in outer membrane permeability. However, the genetic and molecular mechanisms of transformation of a penicillin-susceptible strain of N. gonorrhoeae to high-leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Ropp PA,Hu M,Olesky M,Nicholas RA

更新日期：2002-03-01 00:00:00

abstract：:Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is...

journal_title：Antimicrobial agents and chemotherapy

authors： de Aguiar Cordeiro R,de Farias Marques FJ,de Aguiar Cordeiro R,da Silva MR,Donato Maia Malaquias A,Silva de Melo CV,Mafezoli J,Ferreira de Oliveira Mda C,Nogueira Brilhante RS,Gadelha Rocha MF,Pinheiro Gomes Bandeira Tde J,Costa Si

更新日期：2014-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) NS3 protease inhibitors (PIs) are important components of novel HCV therapy regimens. Studies of PI resistance initially focused on genotype 1. Therefore, knowledge about the determinants of PI resistance for the highly prevalent genotypes 2 to 6 remains limited. Using Huh7.5 cell culture-infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Serre SB,Jensen SB,Ghanem L,Humes DG,Ramirez S,Li YP,Krarup H,Bukh J,Gottwein JM

更新日期：2016-05-23 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:Immunoprecipitation of antigens translated in vitro from Echinococcus granulosus RNA revealed that albendazole treatment of human hydatidosis induced antibodies to previously undetectable antigens and that the response to most antigens was specific, although cross-reactivity was observed between Schistosoma mansoni an...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanton RE,Okelo GB,Kijobe J,King CH

更新日期：1991-08-01 00:00:00

abstract：:Sch 21420 is a new aminoglycoside synthesized from gentamicin B. Susceptibility tests with Sch 21420, amikacin, gentamicin, netilmicin, sisomicin, and tobramycin were performed on a variety of bacterial species including 44 with known mechanisms of resistance to aminoglycosides. Sch 21420 and amikacin had similar effe...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Barry AL,Jones RN,Baker CN,Badal RE,Packer RR

更新日期：1980-08-01 00:00:00

abstract：:The pharmacokinetics of the antifungal pradimicin derivative BMS 181184 in plasma of normal, catheterized rabbits were characterized after single and multiple daily intravenous administrations of dosages of 10, 25, 50, or 150 mg/kg of body weight, and drug levels in tissues were assessed after multiple dosing. Concent...

journal_title：Antimicrobial agents and chemotherapy

authors： Groll AH,Sein T,Petraitis V,Petraitiene R,Callender D,Gonzalez CE,Giri N,Bacher J,Piscitelli S,Walsh TJ

更新日期：1998-10-01 00:00:00

abstract：:Candida glabrata, the second most common cause of Candida infections, is associated with high rates of mortality and often exhibits resistance to the azole class of antifungal agents. Upc2 and Ecm22 in Saccharomyces cerevisiae and Upc2 in Candida albicans are the transcriptional regulators of ERG11, the gene encoding ...

journal_title：Antimicrobial agents and chemotherapy

authors： Whaley SG,Caudle KE,Vermitsky JP,Chadwick SG,Toner G,Barker KS,Gygax SE,Rogers PD

更新日期：2014-08-01 00:00:00

abstract：:The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of > or = 17 microM) and an indifferent interaction with chloroqu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong RP,Davis TM

更新日期：2009-05-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Limburg E,Gahlmann R,Kroll HP,Beyer D

更新日期：2004-02-01 00:00:00

abstract：:The National Committee for Clinical Laboratory Standards has proposed a reference broth macrodilution method for in vitro antifungal susceptibility testing of yeasts (the M27-P method). This method is cumbersome and time-consuming and includes MIC endpoint determination by visual and subjective inspection of growth in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Tudela JL,Berenguer J,Martínez-Suárez JV,Sanchez R

更新日期：1996-09-01 00:00:00

abstract：:The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of...

journal_title：Antimicrobial agents and chemotherapy

authors： Bauernfeind A,Stemplinger I,Jungwirth R,Giamarellou H

更新日期：1996-01-01 00:00:00

abstract：:The effects of trifluorothymidine (5-trifluoromethyl-2'-deoxyuridine, F3dThd) on the replication of three mouse cell lines, LM929, Ltk- (and LM929 derivative devoid of cytosolic deoxythymidine [dThd] kinase activity), and Ltk- c139 (a Ltk- derivative which expresses herpes simplex virus type 1-specified dThd kinase su...

journal_title：Antimicrobial agents and chemotherapy

authors： Wigdahl BL,Parkhurst JR

更新日期：1981-05-01 00:00:00

abstract：:Multiresistant enterococci were tested for susceptibility to trimethoprim (TMP). Although most enterococci are inhibited by less than or equal to 1.0 microgram/ml, the MICs for 7 of 29 selected multiresistant isolates were greater than or equal to 8 micrograms/ml, including for two beta-lactamase positive (Bla+) strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Frosolono M,Hodel-Christian SL,Murray BE

更新日期：1991-09-01 00:00:00