Sequential therapy with caspofungin and fluconazole for Candida albicans infection.


:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorable therapeutic option for treatment of systemic candidiasis.


Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G




Has Abstract


2004-10-01 00:00:00














  • Action of uracil analogs on human immunodeficiency virus type 1 and its reverse transcriptase.

    abstract::Three structural analogs of 5-ethyl-1-benzyloxymethyl-6-(phenylthio)uracil (E-BPU) inhibited human immunodeficiency virus type 1 (HIV-1) replication without cytotoxicity in vitro and were more potent than azidothymidine and were as potent as E-BPU. The target of these compounds is HIV-1 reverse transcriptase. Reverse ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Piras G,Dutschman GE,Im GJ,Pan BC,Chu SH,Cheng YC

    更新日期:1995-02-01 00:00:00

  • Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults.

    abstract::In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hayden FG,Monto AS

    更新日期:1986-02-01 00:00:00

  • In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.

    abstract::LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

    更新日期:2010-12-01 00:00:00

  • In vitro activity of systemic antifungal agents against Malassezia furfur.

    abstract::The activity of four antifungal agents against 15 systemic (blood and vascular catheter) and 10 superficial (skin) Malassezia furfur isolates was evaluated. MIC ranges were similar for the two groups of organisms: amphotericin B, 0.3 to 2.5 micrograms/ml; flucytosine, greater than 100 micrograms/ml; miconazole, 0.4 to...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Marcon MJ,Durrell DE,Powell DA,Buesching WJ

    更新日期:1987-06-01 00:00:00

  • Biofilm compared to conventional antimicrobial susceptibility of Stenotrophomonas maltophilia Isolates from cystic fibrosis patients.

    abstract::Stenotrophomonas maltophilia is a multidrug-resistant organism increasingly isolated from the lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 CF patients underwent planktonic and biofilm susceptibility testing against 9 different antibiotics, alone and in double antibiot...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wu K,Yau YC,Matukas L,Waters V

    更新日期:2013-03-01 00:00:00

  • In vitro activity of PD 127,391, an enhanced-spectrum quinolone.

    abstract::The in vitro activity of PD 127,391, a dihalogenated quinolone, was compared with those of ofloxacin, ciprofloxacin, nalidixic acid, gentamicin, and cefuroxime against 525 recent isolates and well-characterized antimicrobial agent-resistant strains. The MICs of PD 127,391 against 90% of members of the family Enterobac...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wise R,Ashby JP,Andrews JM

    更新日期:1988-08-01 00:00:00

  • Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.

    abstract::Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

    更新日期:2008-11-01 00:00:00

  • Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.

    abstract::Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn pat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Mohr JF 3rd,Ostrosky-Zeichner L,Wainright DJ,Parks DH,Hollenbeck TC,Ericsson CD

    更新日期:2008-05-01 00:00:00

  • Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis.

    abstract::The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yotsuji A,Mitsuyama J,Hori R,Yasuda T,Saikawa I,Inoue M,Mitsuhashi S

    更新日期:1988-12-01 00:00:00

  • Influence of urinary pH on the pharmacokinetics of cinoxacin in humans and on antibacterial activity in vitro.

    abstract::The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. P...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barbhaiya RH,Gerber AU,Craig WA,Welling PG

    更新日期:1982-03-01 00:00:00

  • In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015.

    abstract::Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in use, including carbapenems. A total of 45,872 Enterobacteriaceae ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kazmierczak KM,Bradford PA,Stone GG,de Jonge BLM,Sahm DF

    更新日期:2018-11-26 00:00:00

  • Effect of ginkgo biloba on the pharmacokinetics of raltegravir in healthy volunteers.

    abstract::Medicinal herbs may cause clinically relevant drug interactions with antiretroviral agents. Ginkgo biloba extract is a popular herbal product among HIV-infected patients because of its positive effects on cognitive function. Raltegravir, an HIV integrase inhibitor, is increasingly being used as part of combined antire...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Blonk M,Colbers A,Poirters A,Schouwenberg B,Burger D

    更新日期:2012-10-01 00:00:00

  • In vitro activity of gemifloxacin (SB 265805) against anaerobes.

    abstract::Gemifloxacin mesylate (SB 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the National Committee for Clinical Laboratory Standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) CFU/spot. Comparative antimicrobials tested i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Citron DM,Warren Y,Tyrrell K,Merriam CV

    更新日期:1999-09-01 00:00:00

  • Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.

    abstract::Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Li C,Lewis MR,Gilbert AB,Noel MD,Scoville DH,Allman GW,Savage PB

    更新日期:1999-06-01 00:00:00

  • Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia.

    abstract::Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Alvarez A,Moncayo JI,Santacruz JJ,Santacoloma M,Corredor LF,Reinosa E

    更新日期:2009-09-01 00:00:00

  • New rapid assay for nafcillin in serum by spectrofluorometry.

    abstract::A new, rapid method for measuring serum levels of nafcillin by spectrofluorometry is described. The method involves extraction of 2 ml of acidified serum with n-butyl chloride, subjecting the organic solvent layer to excitation at 340 nm, and measuring the relative intensity of emission fluorescence at 380 nm. An exce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lichtenwalner DM,Suh B,Lorber B,Sugar AM

    更新日期:1979-08-01 00:00:00

  • Safety and bactericidal activity of rifalazil in patients with pulmonary tuberculosis.

    abstract::Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy volunteers showed that once...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dietze R,Teixeira L,Rocha LM,Palaci M,Johnson JL,Wells C,Rose L,Eisenach K,Ellner JJ

    更新日期:2001-07-01 00:00:00

  • Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine.

    abstract::Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gobert JM,Remington KM,Zhu YQ,North TW

    更新日期:1994-04-01 00:00:00

  • Efficacy and safety of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 milligrams twice daily for 5 days versus amoxicillin-clavulanate at 875/125 milligrams twice daily for 7 days in the treatment of acute exacerbations of chronic bronc

    abstract::This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sethi S,Breton J,Wynne B

    更新日期:2005-01-01 00:00:00

  • Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts.

    abstract::Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

    更新日期:1994-11-01 00:00:00

  • Penetration of aztreonam into human bronchial secretions.

    abstract::Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

    更新日期:1985-02-01 00:00:00

  • Effect of cefamandole nafate on the toxicity of tobramycin.

    abstract::Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wold JS,Turnipseed SA,Broddle WD,Owen NV

    更新日期:1977-10-01 00:00:00

  • Mechanism of Pseudomonas aeruginosa persistence during treatment with broad-spectrum cephalosporins of lung infections in patients with cystic fibrosis.

    abstract::Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

    更新日期:1987-09-01 00:00:00

  • A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors.

    abstract::We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shi C,Mellors JW

    更新日期:1997-12-01 00:00:00

  • Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen.

    abstract::A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jung H,Medina R,Castro N,Corona T,Sotelo J

    更新日期:1997-06-01 00:00:00

  • Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters.

    abstract::The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug efflux transporters. Raltegravir uptake, accumulation, and permeability were evaluated in vitro in (i) P-glycoprotein (P-gp), breast cancer resistance protein (BCRP...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hoque MT,Kis O,De Rosa MF,Bendayan R

    更新日期:2015-05-01 00:00:00

  • Mutations Associated with Decreased Susceptibility to Seven Antimicrobial Families in Field and Laboratory-Derived Mycoplasma bovis Strains.

    abstract::The molecular mechanisms of resistance to fluoroquinolones, tetracyclines, an aminocyclitol, macrolides, a lincosamide, a phenicol, and pleuromutilins were investigated in Mycoplasma bovis For the identification of mutations responsible for the high MICs of certain antibiotics, whole-genome sequencing of 35 M. bovis f...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sulyok KM,Kreizinger Z,Wehmann E,Lysnyansky I,Bányai K,Marton S,Jerzsele Á,Rónai Z,Turcsányi I,Makrai L,Jánosi S,Nagy SÁ,Gyuranecz M

    更新日期:2017-01-24 00:00:00

  • Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci.

    abstract::The innovation of new therapies to combat multidrug-resistant (MDR) bacteria is being outpaced by the continued rise of MDR bacterial infections. Of particular concern are hospital-acquired infections (HAIs) that are recalcitrant to antibiotic therapies. The Gram-positive intestinal pathobiont Enterococcus faecalis is...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rodrigues M,McBride SW,Hullahalli K,Palmer KL,Duerkop BA

    更新日期:2019-10-22 00:00:00

  • Biochemical properties of a carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli.

    abstract::A clinical isolate of Enterobacter cloacae, strain NOR-1, exhibited resistance to imipenem and remained susceptible to extended-spectrum cephalosporins. Clavulanic acid partially restored the susceptibility of the strain to imipenem. Two beta-lactamases with isoelectric points (pI) of 6.9 and > 9.2 were detected in st...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nordmann P,Mariotte S,Naas T,Labia R,Nicolas MH

    更新日期:1993-05-01 00:00:00

  • Chitosan augments photodynamic inactivation of gram-positive and gram-negative bacteria.

    abstract::Antimicrobial photodynamic inactivation (PDI) was shown to be a promising treatment modality for microbial infections. This study explores the effect of chitosan, a polycationic biopolymer, in increasing the PDI efficacy against Gram-positive bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, Strep...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tsai T,Chien HF,Wang TH,Huang CT,Ker YB,Chen CT

    更新日期:2011-05-01 00:00:00