当前位置： SCI文献检索 > ANTIMICROBIAL AGENTS AND CHEMOTHERAPY期刊下所有文献 > Synergy of silver nanoparticles and aztreonam against Pseudomonas aeruginosa PAO1 biofilms.

Synergy of silver nanoparticles and aztreonam against Pseudomonas aeruginosa PAO1 biofilms.

Abstract：

:Pathogenic bacterial biofilms, such as those found in the lungs of patients with cystic fibrosis (CF), exhibit increased antimicrobial resistance, due in part to the inherent architecture of the biofilm community. The protection provided by the biofilm limits antimicrobial dispersion and penetration and reduces the efficacy of antibiotics that normally inhibit planktonic cell growth. Thus, alternative antimicrobial strategies are required to combat persistent infections. The antimicrobial properties of silver have been known for decades, but silver and silver-containing compounds have recently seen renewed interest as antimicrobial agents for treating bacterial infections. The goal of this study was to assess the efficacy of citrate-capped silver nanoparticles (AgNPs) of various sizes, alone and in combination with the monobactam antibiotic aztreonam, to inhibit Pseudomonas aeruginosa PAO1 biofilms. Among the different sizes of AgNPs examined, 10-nm nanoparticles were most effective in inhibiting the recovery of P. aeruginosa biofilm cultures and showed synergy of inhibition when combined with sub-MIC levels of aztreonam. Visualization of biofilms treated with combinations of 10-nm AgNPs and aztreonam indicated that the synergistic bactericidal effects are likely caused by better penetration of the small AgNPs into the biofilm matrix, which enhances the deleterious effects of aztreonam against the cell envelope of P. aeruginosa within the biofilms. These data suggest that small AgNPs synergistically enhance the antimicrobial effects of aztreonam against P. aeruginosa in vitro, and they reveal a potential role for combinations of small AgNPs and antibiotics in treating patients with chronic infections.

journal_name

Antimicrob Agents Chemother

journal_title

Antimicrobial agents and chemotherapy

authors

Habash MB,Park AJ,Vis EC,Harris RJ,Khursigara CM

doi

10.1128/AAC.03170-14

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

5818-30

issue

10

eissn

0066-4804

issn

1098-6596

pii

AAC.03170-14

journal_volume

58

pub_type

杂志文章

相关文献

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY文献大全
  • Phase 1 safety and pharmacokinetic study of chimeric murine-human monoclonal antibody c alpha Stx2 administered intravenously to healthy adult volunteers.

    abstract：:Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c alpha Stx2, that h...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1128/AAC.49.5.1808-1812.2005

    authors： Dowling TC,Chavaillaz PA,Young DG,Melton-Celsa A,O'Brien A,Thuning-Roberson C,Edelman R,Tacket CO

    更新日期：2005-05-01 00:00:00

  • Induction of the Citrobacter freundii group I beta-lactamase in Escherichia coli is not dependent on entry of beta-lactam into the cytoplasm.

    abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.34.12.2429

    authors： Everett MJ,Chopra I,Bennett PM

    更新日期：1990-12-01 00:00:00

  • R plasmids from Asian strains of Vibrio cholerae.

    abstract：:Five R plasmids transferred from Asian strains of Vibrio cholerae all proved to be members of compatibility group C. A non-self-transmissible plasmid, stable in V. cholerae, was mobilized for transfer to Escherichia coli K-12 and found to be unstably inherited in that host. Plasmids of group C and P transferred to a w...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.11.4.585

    authors： Hedges RW,Vialard JL,Pearson NJ,O'Grady F

    更新日期：1977-04-01 00:00:00

  • Antibiotic susceptibilities of Salmonella enterica serovar Typhi and S. enterica serovar Paratyphi A isolated from patients in Japan.

    abstract：:The antibiotic susceptibilities of 62 strains of Salmonella enterica serovar Typhi and 37 strains of S. enterica serovar Paratyphi A were investigated with 18 antibiotics. Eighteen S. enterica serovar Typhi isolates and five S. enterica serovar Paratyphi A isolates were resistant to one or more antimicrobial agents, a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.45.3.956-958.2001

    authors： Hirose K,Tamura K,Sagara H,Watanabe H

    更新日期：2001-03-01 00:00:00

  • Evaluating the Relationship between Vancomycin Trough Concentration and 24-Hour Area under the Concentration-Time Curve in Neonates.

    abstract：:Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC24/MIC) of >400 as the...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01647-17

    authors： Tseng SH,Lim CP,Chen Q,Tang CC,Kong ST,Ho PC

    更新日期：2018-03-27 00:00:00

  • In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.

    abstract：:We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobact...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00365-15

    authors： Barth N,Ribeiro VB,Zavascki AP

    更新日期：2015-01-01 00:00:00

  • Action of polymyxin B on bacterial membranes: phosphatidylglycerol- and cardiolipin-induced susceptibility to polymyxin B in Acholeplasma laidlawii B.

    abstract：:To identify the polymyxin receptor molecules in the membranes of living microorganisms, fusion of intact Acholeplasma laidlawii B with lipid vesicles was investigated according to the procedure of Grant and McConnell (1973). The naturally polymyxin-resistant A. laidlawii B was treated with phospholipid vesicles prepar...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.9.1.26

    authors： Teuber M,Bader J

    更新日期：1976-01-01 00:00:00

  • Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.

    abstract：:In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00996-10

    authors： Swick MC,Morgan-Linnell SK,Carlson KM,Zechiedrich L

    更新日期：2011-02-01 00:00:00

  • 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.

    abstract：:The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we report the discovery of a novel class of HCV polymerase nonnucleoside...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00669-08

    authors： Nyanguile O,Pauwels F,Van den Broeck W,Boutton CW,Quirynen L,Ivens T,van der Helm L,Vandercruyssen G,Mostmans W,Delouvroy F,Dehertogh P,Cummings MD,Bonfanti JF,Simmen KA,Raboisson P

    更新日期：2008-12-01 00:00:00

  • Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.

    abstract：:The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DN...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.34.3.473

    authors： Fourel I,Hantz O,Watanabe KA,Jacquet C,Chomel B,Fox JJ,Trepo C

    更新日期：1990-03-01 00:00:00

  • Proof-of-Principle Study in a Murine Lung Infection Model of Antipseudomonal Activity of Phage PEV20 in a Dry-Powder Formulation.

    abstract：:Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been documented to be efficacious against multidrug-resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, p...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01714-17

    authors： Chang RYK,Chen K,Wang J,Wallin M,Britton W,Morales S,Kutter E,Li J,Chan HK

    更新日期：2018-01-25 00:00:00

  • Cefoxitin inactivation by Bacteroides fragilis.

    abstract：:We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.24.6.936

    authors： Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

    更新日期：1983-12-01 00:00:00

  • An Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase Inhibitors.

    abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00539-19

    authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

    更新日期：2019-07-25 00:00:00

  • Activities of new antimicrobial agents (trovafloxacin, moxifloxacin, sanfetrinem, and quinupristin-dalfopristin) against Bacteroides fragilis group: comparison with the activities of 14 other agents.

    abstract：:The antimicrobial activities of trovafloxacin, moxifloxacin, sanfetrinem, quinupristin-dalfopristin, and 14 other antimicrobial agents against 218 Bacteroides fragilis group strains were determined. A group of 10 imipenem-resistant strains were also tested. Imipenem, meropenem, and sanfetrinem had the lowest MICs of a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.43.9.2320

    authors： Betriu C,Gómez M,Palau ML,Sánchez A,Picazo JJ

    更新日期：1999-09-01 00:00:00

  • Optimal sampling schedule design for populations of patients.

    abstract：:Generation of pharmacodynamic relationships in the clinical arena requires estimation of pharmacokinetic parameter values for individual patients. When the target population is severely ill, the ability to obtain traditional intensive blood sampling schedules is curtailed. Population modeling guided by optimal samplin...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1128/aac.47.9.2888-2891.2003

    authors： Tam VH,Preston SL,Drusano GL

    更新日期：2003-09-01 00:00:00

  • In vitro activity of RP 74501-RP 74502, a novel streptogramin antimicrobial mixture, against clinical isolates of Legionella species.

    abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.37.4.908

    authors： Edelstein PH,Edelstein MA

    更新日期：1993-04-01 00:00:00

  • Inducible high resistance to colistin in Proteus strains.

    abstract：:Wild-type Proteus strains are usually resistant to colistin. We have observed an increase in the level of colistin resistance in four clinical isolates of P. vulgaris, P. morganii, and P. rettgeri by prior treatment with subinhibitory concentrations of the drug. The enhanced resistance in these strains was lost after ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.12.1.1

    authors： Shimizu S,Iyobe S,Mitsuhashi S

    更新日期：1977-07-01 00:00:00

  • Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine.

    abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.01499-17

    authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

    更新日期：2017-10-24 00:00:00

  • Ritonavir increases plasma amprenavir (APV) exposure to a similar extent when coadministered with either fosamprenavir or APV.

    abstract：:To compare the effect of ritonavir on plasma amprenavir pharmacokinetics, healthy adults received either fosamprenavir (700 mg twice a day [BID]) or amprenavir (600 mg BID) alone and in combination with ritonavir (100 mg BID). Ritonavir increased plasma amprenavir pharmacokinetic parameters to a similar extent when co...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1128/AAC.50.4.1578-1580.2006

    authors： Wire MB,Baker KL,Jones LS,Shelton MJ,Lou Y,Thomas GJ,Berrey MM

    更新日期：2006-04-01 00:00:00

  • In Vivo Pharmacodynamic Evaluation of Omadacycline against Staphylococcus aureus in the Neutropenic Mouse Pneumonia Model.

    abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.02058-19

    authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

    更新日期：2020-01-27 00:00:00

  • Severe Renal Impairment Has Minimal Impact on Doravirine Pharmacokinetics.

    abstract：:Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 临床试验,杂志文章

    doi：10.1128/AAC.00326-18

    authors： Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

    更新日期：2018-07-27 00:00:00

  • Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine.

    abstract：:We have found a close correlation between viral stavudine (d4T) resistance and resistance to d4T-triphosphate at the human immunodeficiency virus type 1 reverse transcriptase (RT) level. RT from site-directed mutants with 69S-XX codon insertions and/or conventional zidovudine resistance mutations seems to be involved ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.45.7.2144-2146.2001

    authors： Lennerstrand J,Stammers DK,Larder BA

    更新日期：2001-07-01 00:00:00

  • Selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora.

    abstract：:Intestinal endogenous members of the family Enterobacteriaceae were eliminated in 12 human volunteers treated with 400 or 800 mg of oral norfloxacin per day for 5 days. No clones resistant to quinolone derivatives were isolated. Counts of aerotolerant streptococci were affected to various degrees, depending on their s...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.29.6.1047

    authors： Pecquet S,Andremont A,Tancrède C

    更新日期：1986-06-01 00:00:00

  • Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR.

    abstract：:Pseudomonas putida is well known for its metabolic capabilities, but recently, it has been shown to exhibit resistance to a wide range of antibiotics. In P. putida DOT-T1E, the TtgABC efflux pump, which has a broad substrate specificity, extrudes antibiotics such as ampicillin, carbenicillin, tetracycline, nalidixic a...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.47.10.3067-3072.2003

    authors： Terán W,Felipe A,Segura A,Rojas A,Ramos JL,Gallegos MT

    更新日期：2003-10-01 00:00:00

  • The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice.

    abstract：:The resistance-nodulation-division (RND)-type efflux pump is one of the causes of the multidrug resistance of Stenotrophomonas maltophilia. The roles of the RND-type efflux pump in physiological functions and virulence, in addition to antibiotic extrusion, have attracted much attention. In this study, the contribution...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00372-15

    authors： Lin YT,Huang YW,Chen SJ,Chang CW,Yang TC

    更新日期：2015-07-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.

    abstract：:Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.15.2.240

    authors： Feldman WE,Zweighaft T

    更新日期：1979-02-01 00:00:00

  • Biliary excretion of imipenem-cilastatin in hospitalized patients.

    abstract：:Imipenem-cilastatin concentrations in bile were measured in 12 cholecystectomy patients (group 1) and 12 patients with common duct drainage (group 2). Six patients in each group received 0.5 g, and six received 1.0 g intravenously over 30 to 60 min. In group 1, bile was collected a mean of 85 min postinfusion. The mea...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.31.11.1718

    authors： Graziani AL,Gibson GA,MacGregor RR

    更新日期：1987-11-01 00:00:00

  • In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis complex isolated in Taiwan over 10 years.

    abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/AAC.00414-07

    authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

    更新日期：2008-06-01 00:00:00

  • Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.

    abstract：:Spectinomycin resistance in clinical isolates of Neisseria meningitidis and Neisseria gonorrhoeae was found to be due to mutations G1064C and C1192U (Escherichia coli numbering) in 16S rRNA genes, respectively. ...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.44.5.1365-1366.2000

    authors： Galimand M,Gerbaud G,Courvalin P

    更新日期：2000-05-01 00:00:00

  • Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs.

    abstract：:Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical A...

    journal_title：Antimicrobial agents and chemotherapy

    pub_type： 杂志文章

    doi：10.1128/aac.28.1.103

    authors： Spruance SL,Freeman DJ,Sheth NV

    更新日期：1985-07-01 00:00:00