Effect of antiviral agents on replication of herpes simplex virus type 1 in brain cultures.

abstract：:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

更新日期：2014-06-01 00:00:00

abstract：:The Chinese traditional medicine mao-bushi-saishin-to (MBST), which has anti-inflammatory effects and has been used to treat the common cold and nasal allergy in Japan, was examined for its effects on the therapeutic activity of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium avium complex (MAC) infe...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu T,Tomioka H,Sato K,Sano C,Akaki T,Dekio S,Yamada Y,Kamei T,Shibata H,Higashi N

更新日期：1999-03-01 00:00:00

abstract：:Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-beta-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within C...

journal_title：Antimicrobial agents and chemotherapy

authors： Villegas MV,Lolans K,del Rosario Olivera M,Suarez CJ,Correa A,Queenan AM,Quinn JP,Colombian Nosocomial Resistance Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Nocardia species are gram-positive environmental saprophytes, but some cause the infectious disease nocardiosis. The complete genomic sequence of Nocardia farcinica IFM 10152 has been determined, and analyses indicated the presence of two different RNA polymerase beta subunit genes, rpoB and rpoB2, in the genome (J. I...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa J,Chiba K,Kurita H,Satoh H

更新日期：2006-04-01 00:00:00

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Towner KJ,Smith MA,Cowlishaw WA

更新日期：1983-04-01 00:00:00

abstract：:Adenosine monophosphate pretreatment of mice with latent herpes simplex virus type 1 infections significantly reduced the rate of reactivation of latent virus. Adenosine monophosphate pretreatment did not, however, eradicate latent virus. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Blue WT,Winland RD,Stobbs DG,Kirksey DF,Savage RE

更新日期：1981-10-01 00:00:00

abstract：:Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

更新日期：1973-05-01 00:00:00

abstract：:The integrase inhibitor raltegravir (RAL) is currently used for the treatment of both treatment-naïve and treatment-experienced HIV-1-infected patients. Elvitegravir (EVG) is in late phases of clinical development. Since significant cross-resistance between RAL and EVG is observed, there is a need for second-generatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Wesenbeeck L,Rondelez E,Feyaerts M,Verheyen A,Van der Borght K,Smits V,Cleybergh C,De Wolf H,Van Baelen K,Stuyver LJ

更新日期：2011-01-01 00:00:00

abstract：:beta-Lactamase was purified from a strain of Legionella gormanii. The molecular weight of the purified enzyme was 25,000, and its isoelectric point was 10.5. The enzyme hydrolyzed oxyiminocephalosporins, cephamycins, penicillins, and imipenem. The enzyme activity was inhibited by EDTA, Hg2+, and Cu2+, but not by clavu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fujii T,Sato K,Miyata K,Inoue M,Mitsuhashi S

更新日期：1986-05-01 00:00:00

abstract：:MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KR...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomioka H,Saito H,Fujii K,Sato K,Hidaka T

更新日期：1993-01-01 00:00:00

abstract：:The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cherubin CE,Corrado ML,Sierra MF,Gombert ME,Shulman M

更新日期：1981-10-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new antiechinococcosis drugs. Metformin is an antihyperglycemic and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Loos JA,Dávila VA,Brehm K,Cumino AC

更新日期：2020-08-20 00:00:00

abstract：:The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ouyang-Latimer J,Jafri S,VanTassel A,Jiang ZD,Gurleen K,Rodriguez S,Nandy RK,Ramamurthy T,Chatterjee S,McKenzie R,Steffen R,DuPont HL

更新日期：2011-02-01 00:00:00

abstract：:PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located in composite transposon Tn1213 made by two distinct insertion sequences, namely, ISPa12 and ISPa13. In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the blaPER-1 gene, although at a ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Mancini S,Poirel L,Kieffer N,Nordmann P

更新日期：2018-02-23 00:00:00

abstract：:Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniaecarbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the concentrations of both ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Rubio-Aparicio D,Nelson K,Dudley MN,Lomovskaya O

更新日期：2017-11-22 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have emerged as major nosocomial pathogens. bla(KPC), commonly located on Tn4401, is found in Gram-negative bacterial strains, with the two most common variants, bla(KPC-2) and bla(KPC-3), identified in plasmids with diverse genetic backgrounds. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen L,Chavda KD,Fraimow HS,Mediavilla JR,Melano RG,Jacobs MR,Bonomo RA,Kreiswirth BN

更新日期：2013-01-01 00:00:00

abstract：:Susceptibility of pathogenic aerobic bacteria to moxalactam (LY127935) was compared by two methods, diffusion from 30-microgram disks and agar plate dilution. The two methods gave a satisfactory degree of correlation when compared by linear regression, but the slope of the linear regression was significantly steeper f...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ

更新日期：1981-01-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be ...

journal_title：Antimicrobial agents and chemotherapy

authors： Davidson MG,Lappin MR,Rottman JR,Tompkins MB,English RV,Bruce AT,Jayawickrama J

更新日期：1996-06-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infections, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk but might increase the risks of renal or liver toxicity or Clostridium diffici...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Huskey RL,Tang L,Inaba H,Gaur AH,Ribeiro R,Rubnitz JE,Wolf J

更新日期：2018-02-23 00:00:00

abstract：:Although acetylsalicylic acid does not itself induce interferon, acetylsalicylic acid was found to significantly enhance the production of both human alpha interferon and human gamma interferon when added with the appropriate inducers to cultures of human peripheral blood mononuclear cells. The mechanisms associated w...

journal_title：Antimicrobial agents and chemotherapy

authors： Yousefi S,Chiu J,Carandang G,Archibeque EG,Vaziri N,Cesario TC

更新日期：1987-01-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:The recent availability of CCR5 antagonists as anti-human immunodeficiency virus (anti-HIV) therapeutics has highlighted the need to accurately identify CXCR4-using variants in patient samples when use of this new drug class is considered. The Trofile assay (Monogram Biosciences) has become the method that is the most...

journal_title：Antimicrobial agents and chemotherapy

authors： Coakley E,Reeves JD,Huang W,Mangas-Ruiz M,Maurer I,Harskamp AM,Gupta S,Lie Y,Petropoulos CJ,Schuitemaker H,van 't Wout AB

更新日期：2009-11-01 00:00:00