Comparison of hydrogen peroxide contact lens disinfection systems and solutions against Acanthamoeba polyphaga.

abstract：:We tested 32 Candida isolates recovered in the early 1990s from the bloodstreams of patients with candidemia for in vitro susceptibility to fluconazole and determined if MIC and/or the daily dose of fluconazole/MIC ratio correlated with the response to therapy. This is a unique data set since 87.5% (28/32) of patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Clancy CJ,Yu VL,Morris AJ,Snydman DR,Nguyen MH

更新日期：2005-08-01 00:00:00

abstract：:Invasive aspergillosis (IA) is a severe condition mainly caused by Aspergillus fumigatus, although other species of the genus, such as section Nigri members, can also be involved. Voriconazole (VRC) is the recommended treatment for IA; however, the prevalence of azole-resistant Aspergillus isolates has alarmingly incr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez-Cantero A,López-Fernández L,Guarro J,Capilla J

更新日期：2019-06-24 00:00:00

abstract：:Acute pulmonary exacerbations (APE) involving Pseudomonas aeruginosa are associated with increased morbidity and mortality in cystic fibrosis (CF) patients. Drug resistance is a significant challenge to treatment. Ceftazidime-avibactam (CZA) demonstrates excellent in vitro activity against isolates recovered from CF p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bensman TJ,Wang J,Jayne J,Fukushima L,Rao AP,D'Argenio DZ,Beringer PM

更新日期：2017-09-22 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:Mezlocillin is a new broad-spectrum semisynthetic penicillin that has shown encouraging in vitro activity against the infecting organisms most likely to cause mortality and morbidity in cancer patients receiving chemotherapy. The serum clearances and urine recoveries of mezlocillin, ampicillin, and carbenicillin were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Issell BF,Bodey GP,Weaver S

更新日期：1978-02-01 00:00:00

abstract：:TEM- and SHV-type extended-spectrum beta-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although substitutions at residues 104 (E to K), 164 (R to S or H), 238 (G to S...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Ruzin A,Tuckman M,Visalli MA,Petersen PJ,Bradford PA

更新日期：2009-03-01 00:00:00

abstract：:Active nuclear importation of the human immunodeficiency virus (HIV) type 1 (HIV-1) preintegration complex (PIC) is required for the productive infection of nondividing cells, but it is believed to be dispensable for the infection of proliferating cells, such as activated T lymphocytes. To investigate this question, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Haffar OK,Smithgall MD,Popov S,Ulrich P,Bruce AG,Nadler SG,Cerami A,Bukrinsky MI

更新日期：1998-05-01 00:00:00

abstract：:Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD...

journal_title：Antimicrobial agents and chemotherapy

authors： Locher HH,Seiler P,Chen X,Schroeder S,Pfaff P,Enderlin M,Klenk A,Fournier E,Hubschwerlen C,Ritz D,Kelly CP,Keck W

更新日期：2014-01-01 00:00:00

abstract：:Implicated as a major mechanism of ethambutol (EMB) resistance in clinical studies of Mycobacterium tuberculosis, mutations in codon 306 of the embB gene (embB306) have also been detected in EMB-susceptible clinical isolates. Other studies have found strong associations between embB306 mutations and multidrug resistan...

journal_title：Antimicrobial agents and chemotherapy

authors： Safi H,Sayers B,Hazbón MH,Alland D

更新日期：2008-06-01 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:The pharmacokinetics of cefepime were studied in 12 adult patients in intensive care units during continuous venovenous hemofiltration (CVVH) or continuous venovenous hemodiafiltration (CVVHDF) with a Multiflow60 AN69HF 0.60-m(2) polyacrylonitrile hollow-fiber membrane (Hospal Industrie, Meyzieu, France). Patients (me...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-11-01 00:00:00

abstract：:We tested the ability of antimicrobial agents that act on the cell wall to kill enterococci and found defective killing (a minimal bactericidal concentration/minimal inhibitory concentration ratio of greater than or equal to 32) with both beta-lactams (penicillin G and cephalothin) and non-beta-lactams (vancomycin, cy...

journal_title：Antimicrobial agents and chemotherapy

authors： Krogstad DJ,Pargwette AR

更新日期：1980-06-01 00:00:00

abstract：:Thirty-two strains of Trichophyton rubrum and 16 strains of Trichophyton mentagrophytes isolated from patients with tinea unguium in various parts of Germany were subjected to a microdilution test with six systemic or topical antimycotic agents. Apart from griseofulvin, there were no species-specific differences betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Korting HC,Ollert M,Abeck D

更新日期：1995-05-01 00:00:00

abstract：:The in vivo and in vitro determination of significant intracellular stavudine (d4T) triphosphate (d4TTP) concentrations in human immunodeficiency virus (HIV)-infected subjects and NS-1 cells treated with zidovudine (ZDV) has recently been reported. This study was conducted to corroborate these findings with in vivo sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Meléndez M,Blanco R,Delgado W,García R,Santana J,García H,Rosario O,Rodríguez JF

更新日期：2006-03-01 00:00:00

abstract：:The present studies were conducted to better define the mechanism of action of polyethylene hexamethylene biguanide (PEHMB) (designated herein as NB325), which was shown in previous studies to inhibit infection by the human immunodeficiency virus type 1 (HIV-1). Fluorescence-activated flow cytometric analyses of activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Zhu W,Kholodovych V,Welsh W,Rando RF,Labib ME,Wigdahl B,Krebs FC

更新日期：2009-02-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated the effect of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Asfaw YG,Steinbach WJ

更新日期：2014-01-01 00:00:00

abstract：:Oral doses of norfloxacin (80 mg/kg of body weight per day) and ciprofloxacin (25 and 80 mg/kg/day) and intramuscular doses of teicoplanin (5 mg/kg/day), all administered once a day for 10 days, were evaluated as a means of preventing encrusted cystitis caused by Corynebacterium group D2. Zinc disks dipped into a 24-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Soriano F,Rodriguez-Tudela JL,Castilla C,Avilés P

更新日期：1991-12-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:Candida lusitaniae is usually susceptible to echinocandins. Beta-1,3-glucan synthase encoded by FKS genes is the target of echinocandins. A few missense mutations in the C. lusitaniae FKS1 hot spot 1 (HS1) have been reported. We report here the rapid emergence of antifungal resistance in C. lusitaniae isolated during ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asner SA,Giulieri S,Diezi M,Marchetti O,Sanglard D

更新日期：2015-12-01 00:00:00

abstract：:Tigecycline is a glycylcycline with activity against Enterobacteriaceae, including multidrug-resistant isolates of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamase (ESBL) and carbapenemases. Herein, we used an in vivo murine thigh model to characterize the pharmacodynamic profile o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicasio AM,Crandon JL,Nicolau DP

更新日期：2009-07-01 00:00:00

abstract：:Macrolide-resistant group A streptococci (MRGAS) have been recovered from many countries worldwide. However, the strain typing information that is available has been insufficient for estimating the total number of macrolide-resistant clones, their geographic distributions, and their evolutionary relationships. In this...

journal_title：Antimicrobial agents and chemotherapy

authors： Robinson DA,Sutcliffe JA,Tewodros W,Manoharan A,Bessen DE

更新日期：2006-09-01 00:00:00

abstract：:Candida albicans, an opportunistic fungus, and Staphylococcus aureus, a bacterial pathogen, are two clinically relevant biofilm-forming microbes responsible for a majority of catheter-related infections, with such infections often resulting in catheter loss and removal. Not only do these pathogens cause a substantial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Peters BM,Ward RM,Rane HS,Lee SA,Noverr MC

更新日期：2013-01-01 00:00:00

abstract：:We previously showed that the mouse inorganic phosphate transporter Npt1 operates in the hepatic sinusoidal membrane transport of anionic drugs such as benzylpenicillin and mevalonic acid. In the present study, the mechanism of renal secretion of penem antibiotics was examined by using a Xenopus oocyte expression syst...

journal_title：Antimicrobial agents and chemotherapy

authors： Uchino H,Tamai I,Yabuuchi H,China K,Miyamoto K,Takeda E,Tsuji A

更新日期：2000-03-01 00:00:00

abstract：:Carbapenem resistance in Gram-negative bacteria is on the rise in the United States. A regional network was established to study microbiological and genetic determinants of clinical outcomes in hospitalized patients with carbapenem-resistant (CR) Klebsiella pneumoniae in a prospective, multicenter, observational study...

journal_title：Antimicrobial agents and chemotherapy

authors： van Duin D,Perez F,Rudin SD,Cober E,Hanrahan J,Ziegler J,Webber R,Fox J,Mason P,Richter SS,Cline M,Hall GS,Kaye KS,Jacobs MR,Kalayjian RC,Salata RA,Segre JA,Conlan S,Evans S,Fowler VG Jr,Bonomo RA

更新日期：2014-07-01 00:00:00

abstract：:Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infections, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk but might increase the risks of renal or liver toxicity or Clostridium diffici...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Huskey RL,Tang L,Inaba H,Gaur AH,Ribeiro R,Rubnitz JE,Wolf J

更新日期：2018-02-23 00:00:00

abstract：:The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a loading dose of 200 mg tafenoquine base daily for 3 days, followed by a weekly dose of 200 mg tafenoquine for 6 months. Blood samples were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Charles BG,Miller AK,Nasveld PE,Reid MG,Harris IE,Edstein MD

更新日期：2007-08-01 00:00:00

abstract：:Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with potent broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens, including vancomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA), quinolone-resistant MRSA, quinolone-resistant Streptococcus pneumoniae, p...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao GY,Zhang J,Zhang YY,Guo BN,Yu JC,Wu XJ,Chen YC,Wu JF,Shi YG

更新日期：2014-10-01 00:00:00

abstract：:There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest...

journal_title：Antimicrobial agents and chemotherapy

authors： Abe F,Ueyama J,Kawasumi N,Nadai M,Hayashi T,Kato M,Ohnishi M,Saito H,Takeyama N,Hasegawa T

更新日期：2008-09-01 00:00:00