Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.

abstract：:The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Paphitou NI,Ostrosky-Zeichner L,Paetznick VL,Rodriguez JR,Chen E,Rex JH

更新日期：2002-04-01 00:00:00

abstract：:The pharmacodynamics of gemifloxacin against Streptococcus pneumoniae were investigated in a dilutional pharmacodynamic model of infection. Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every...

journal_title：Antimicrobial agents and chemotherapy

authors： MacGowan AP,Rogers CA,Holt HA,Wootton M,Bowker KE

更新日期：2001-10-01 00:00:00

abstract：:Difloxacin, A-56620, cefazolin, cefotaxime, ceftizoxime, cephapirin, SK&F 88070, and spectinomycin were used to compare the in vitro susceptibilities of Mycobacterium avium-M. intracellular isolates from patients with acquired immunodeficiency syndrome (AIDS), patients without AIDS, and diseased animals. Against the i...

journal_title：Antimicrobial agents and chemotherapy

authors： Byrne SK,Geddes GL,Isaac-Renton JL,Black WA

更新日期：1990-07-01 00:00:00

abstract：:Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the po...

journal_title：Antimicrobial agents and chemotherapy

authors： Gendrot M,Diawara S,Madamet M,Kounta MB,Briolant S,Wade KA,Fall M,Benoit N,Nakoulima A,Amalvict R,Diémé Y,Fall B,Wade B,Diatta B,Pradines B

更新日期：2017-02-23 00:00:00

abstract：:Use of combinations of antimicrobials that together achieve synergistic activities against targeted microorganisms is one potential strategy for overcoming bacterial resistance. As the incidence of infections caused by multidrug-resistant staphylococci and enterococci increases, the importance of devising additional s...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Cha R,Rybak MJ

更新日期：2002-08-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:The anti-pseudomonas activities of azlocillin and mezlocillin were compared with that of ticarcillin. We measured the minimal inhibitory and minimal bactericidal concentrations of the three drugs against 20 different strains of Pseudomonas aeruginosa and found significantly lower values for azlocillin than for the oth...

journal_title：Antimicrobial agents and chemotherapy

authors： Coppens L,Klastersky J

更新日期：1979-03-01 00:00:00

abstract：:The pharmacokinetics of oral and intravenous ofloxacin (7.5 mg.kg of body weight-1 given over 30 min) were studied in an open crossover study of 17 Vietnamese children, aged between 5 and 14 years, with acute uncomplicated typhoid fever. Following oral administration, the median (95% confidence interval [CI]) time to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethell DB,Day NP,Dung NM,McMullin C,Loan HT,Tam DT,Minh LT,Linh NT,Dung NQ,Vinh H,MacGowan AP,White LO,White NJ

更新日期：1996-09-01 00:00:00

abstract：:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP50...

journal_title：Antimicrobial agents and chemotherapy

authors： Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JY

更新日期：2005-12-01 00:00:00

abstract：:Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including quinolone-resistant isolates. The mechanistic basis of dione activity vis-à-vis quinolones is not understood. We present evidence for Streptococcus pn...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan XS,Gould KA,Fisher LM

更新日期：2009-09-01 00:00:00

abstract：:Protoplasts of the temperature-sensitive osmotic-1 mutant of Neurospora crassa grew and divided as cell wall-less cells when incubated under certain conditions at 37 degrees C. Each protoplast regenerated cell wall and formed a mycelium when the temperature was shifted to 22 degrees C. Cell wall regeneration, but not ...

journal_title：Antimicrobial agents and chemotherapy

authors： Selitrennikoff CP

更新日期：1983-05-01 00:00:00

abstract：:The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore a...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Bugg TD,Wright GD,Walsh CT,Courvalin P

更新日期：1992-04-01 00:00:00

abstract：:A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jung H,Medina R,Castro N,Corona T,Sotelo J

更新日期：1997-06-01 00:00:00

abstract：:Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence share...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonnet R,Chanal C,Ageron E,Sirot D,De Champs C,Grimont P,Sirot J

更新日期：2002-10-01 00:00:00

abstract：:Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahn J,Ko A,Jun EJ,Won M,Kim YK,Ju ES,Jeon ES,Lee H

更新日期：2012-07-01 00:00:00

abstract：:The activity of two cefoperazone-sulbactam combinations against anaerobic bacteria was tested and compared both with that of cefoperazone alone and with that of other commonly used antimicrobial agents. Imipenem was the most active of the tested agents, followed by chloramphenicol, metronidazole, and cefoperazone-sulb...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Finegold SM

更新日期：1988-03-01 00:00:00

abstract：:Surfing motility is a novel form of surface adaptation exhibited by the nosocomial pathogen Pseudomonas aeruginosa in the presence of the glycoprotein mucin, which is found in high abundance at mucosal surfaces, especially those of the lungs of cystic fibrosis and bronchiectasis patients. Here, we investigated the ada...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun E,Gill EE,Falsafi R,Yeung A,Liu S,Hancock REW

更新日期：2018-08-27 00:00:00

abstract：:Conjugative transfer of R plasmids R64 and R64drd-11 has been compared in vitro and in vivo without selective pressure by antibiotics in a simplified experimental system; the ecosystem was the bowel of germfree chickens, with the host bacteria almost isogenic, and the plasmids differing only in their conjugative trans...

journal_title：Antimicrobial agents and chemotherapy

authors： Sansonetti P,Lafont JP,Jaffé-Brachet A,Guillot JF,Chaslus-Dancla E

更新日期：1980-03-01 00:00:00

abstract：:Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients an...

journal_title：Antimicrobial agents and chemotherapy

authors： Deng F,Shen J,Zhang M,Wu C,Zhang Q,Wang Y

更新日期：2015-10-01 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:Most methicillin-resistant Staphylococcus aureus (MRSA) isolates identified among blood isolates collected in Denmark between 1957 and 1970 belonged to either phage group III or the closely related 83A complex and had a PSTM antibiotype (resistance to penicillin [P], streptomycin [S], tetracycline [T], and methicillin...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomes AR,Westh H,de Lencastre H

更新日期：2006-10-01 00:00:00

abstract：:Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulaf...

journal_title：Antimicrobial agents and chemotherapy

authors： Welte R,Eller P,Lorenz I,Joannidis M,Bellmann R

更新日期：2018-03-27 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:An axenic amastigote culture system was utilized to directly assess the stage-specific antileishmanial effects of antimony on amastigotes of Leishmania donovani devoid of the macrophage host cell. Pentostam, which contains antimony in the form of sodium stibogluconate and the preservative chlorocresol, was used. Cell ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ephros M,Waldman E,Zilberstein D

更新日期：1997-05-01 00:00:00

abstract：:Titanium (Ti) is a promising candidate biomaterial for an artificial corneal skirt. Antimicrobial peptide (AMP) immobilization may improve the bactericidal effect of the Ti substrate. In this study, we tested the bactericidal efficacy of a functionalized Ti surface in a rabbit keratitis model. A corneal stromal pocket...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan XW,Goh TW,Saraswathi P,Nyein CL,Setiawan M,Riau A,Lakshminarayanan R,Liu S,Tan D,Beuerman RW,Mehta JS

更新日期：2014-09-01 00:00:00

abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

更新日期：2020-01-27 00:00:00

abstract：:TEM- and SHV-type extended-spectrum beta-lactamases (ESBLs) are the most common ESBLs found in the United States and are prevalent throughout the world. Amino acid substitutions at a number of positions in TEM-1 lead to the ESBL phenotype, although substitutions at residues 104 (E to K), 164 (R to S or H), 238 (G to S...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones CH,Ruzin A,Tuckman M,Visalli MA,Petersen PJ,Bradford PA

更新日期：2009-03-01 00:00:00

abstract：:The efficacies of cilofungin and amphotericin B separately and together in mice with disseminated candidiasis were studied. Male CD-1 mice (age, 5 weeks) were infected intravenously with 3 X 10(5) CFU of Candida albicans. At 4 days postinfection, intraperitoneal therapy was initiated and was continued for 14 days. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson LH,Perlman AM,Clemons KV,Stevens DA

更新日期：1991-07-01 00:00:00

abstract：:With the growing global threat of antimicrobial resistance, novel strategies are required for combatting resistant pathogens. Combination therapy, in which multiple drugs are used to treat an infection, has proven highly successful in the treatment of cancer and HIV. However, this practice has proven challenging for t...

journal_title：Antimicrobial agents and chemotherapy

authors： Adamowicz EM,Harcombe WR

更新日期：2020-10-20 00:00:00

abstract：:Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data for colistin are limited to guide dosing. The aim of this study was to develop a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee J,Han S,Jeon S,Hong T,Song W,Woo H,Yim DS

更新日期：2013-05-01 00:00:00