Comparative study of anti-pseudomonas activity of azlocillin, mezlocillin, and ticarcillin.

abstract：:The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP50...

journal_title：Antimicrobial agents and chemotherapy

authors： Grgurina I,Bensaci M,Pocsfalvi G,Mannina L,Cruciani O,Fiore A,Fogliano V,Sorensen KN,Takemoto JY

更新日期：2005-12-01 00:00:00

abstract：:The interrelationships between the pharmacokinetics of zidovudine alone and of zidovudine plus clarithromycin were evaluated with 18 volunteers with AIDS who had no infection with Mycobacterium avium complex or clinical evidence of gastroenteritis. Patients received 200 mg of zidovudine orally every 8 h on days 1 to 4...

journal_title：Antimicrobial agents and chemotherapy

authors： Vance E,Watson-Bitar M,Gustavson L,Kazanjian P

更新日期：1995-06-01 00:00:00

abstract：:Pathogenic bacterial biofilms, such as those found in the lungs of patients with cystic fibrosis (CF), exhibit increased antimicrobial resistance, due in part to the inherent architecture of the biofilm community. The protection provided by the biofilm limits antimicrobial dispersion and penetration and reduces the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Habash MB,Park AJ,Vis EC,Harris RJ,Khursigara CM

更新日期：2014-10-01 00:00:00

abstract：:Quinazoline-2,4-diones, such as PD 0305970, are new DNA gyrase and topoisomerase IV (topo IV) inhibitors with potent activity against gram-positive pathogens, including quinolone-resistant isolates. The mechanistic basis of dione activity vis-à-vis quinolones is not understood. We present evidence for Streptococcus pn...

journal_title：Antimicrobial agents and chemotherapy

authors： Pan XS,Gould KA,Fisher LM

更新日期：2009-09-01 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Prunier AL,Malbruny B,Tandé D,Picard B,Leclercq R

更新日期：2002-09-01 00:00:00

abstract：:We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goswami M,Subramanian M,Kumar R,Jass J,Jawali N

更新日期：2016-06-20 00:00:00

abstract：:In an open, randomized, six-period crossover study, the pharmacokinetics of ciprofloxacin, gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, and trovafloxacin were compared after a single oral dose in 12 healthy volunteers (6 men and 6 women). The volunteers received 250 mg of ciprofloxacin, 400 mg of gatifloxa...

journal_title：Antimicrobial agents and chemotherapy

authors： Lubasch A,Keller I,Borner K,Koeppe P,Lode H

更新日期：2000-10-01 00:00:00

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:Three hundred ninety-four patients, aged 6 months to 12 years, entered a multicenter, randomized, controlled, investigator-blind study comparing cefdinir, 7 mg/kg of body weight twice a day, with cephalexin, 10 mg/kg four times a day, each given for 10 days. The most common infections treated were impetigo and seconda...

journal_title：Antimicrobial agents and chemotherapy

authors： Tack KJ,Keyserling CH,McCarty J,Hedrick JA

更新日期：1997-04-01 00:00:00

abstract：:The antimicrobial susceptibility and mechanisms of resistance of 109 Shigella and 40 Salmonella isolates from children with diarrhea in southern Mozambique were assessed. The susceptibility to seven antimicrobial agents was tested by disk diffusion, and mechanisms of resistance were searched by PCR or colorimetric met...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandomando I,Jaintilal D,Pons MJ,Vallès X,Espasa M,Mensa L,Sigaúque B,Sanz S,Sacarlal J,Macete E,Abacassamo F,Alonso PL,Ruiz J

更新日期：2009-06-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00

abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

更新日期：2019-07-25 00:00:00

abstract：:In 2009, the first high-level ceftriaxone-resistant Neisseria gonorrhoeae strain (H041) was isolated in Kyoto, Japan. The present study describes an intensified surveillance (antimicrobial resistance and molecular typing) of Neisseria gonorrhoeae isolates in Kyoto and its neighboring prefecture Osaka, Japan, in 2010 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimuta K,Unemo M,Nakayama S,Morita-Ishihara T,Dorin M,Kawahata T,Ohnishi M,Antibiotic-Resistant Gonorrhea Study Group.

更新日期：2013-11-01 00:00:00

abstract：:Time-kill studies were used to examine the in vitro activities of penicillin G, RP 59500, erythromycin, ciprofloxacin, sparfloxacin, and vancomycin against 10 pneumococci expressing various degrees of susceptibility to penicillin and erythromycin. RP 59500 MICs for all strains were 0.5 to 2.0 micrograms/ml, while eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：1994-09-01 00:00:00

abstract：:The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in human...

journal_title：Antimicrobial agents and chemotherapy

authors： Imperi F,Massai F,Ramachandran Pillai C,Longo F,Zennaro E,Rampioni G,Visca P,Leoni L

更新日期：2013-02-01 00:00:00

abstract：:Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational an...

journal_title：Antimicrobial agents and chemotherapy

authors： Gutiérrez O,Juan C,Pérez JL,Oliver A

更新日期：2004-09-01 00:00:00

abstract：:The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobs MR,Abdelhamed AM,Good CE,Rhoads DD,Hujer KM,Hujer AM,Domitrovic TN,Rudin SD,Richter SS,van Duin D,Kreiswirth BN,Greco C,Fouts DE,Bonomo RA

更新日期：2018-12-21 00:00:00

abstract：:Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahoney DF,Koppel GA,Turner JR

更新日期：1976-09-01 00:00:00

abstract：:We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pultz NJ,Stiefel U,Ghannoum M,Helfand MS,Donskey CJ

更新日期：2005-01-01 00:00:00

abstract：:Durlobactam (DUR; also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii The safety and pharmacokinetics (PK) of DUR alone and with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lickliter JD,Lawrence K,O'Donnell J,Isaacs R

更新日期：2020-06-23 00:00:00

abstract：:The pharmacodynamic effects of metronidazole on Trichomonas vaginalis have been poorly characterized. The present in vitro study was performed to characterize the relationship between killing of trichomonads and metronidazole exposure (metronidazole concentration and time of exposure). Five laboratory strains and five...

journal_title：Antimicrobial agents and chemotherapy

authors： Nix DE,Tyrrell R,Müller M

更新日期：1995-08-01 00:00:00

abstract：:Analysis of the transport functions of individual Candida albicans plasma membrane drug efflux pumps is hampered by the multitude of endogenous transporters. We have stably expressed C. albicans Cdr1p, the major pump implicated in multiple-drug-resistance phenotypes, from the genomic PDR5 locus in a Saccharomyces cere...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura K,Niimi M,Niimi K,Holmes AR,Yates JE,Decottignies A,Monk BC,Goffeau A,Cannon RD

更新日期：2001-12-01 00:00:00

abstract：:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandelbrot L,Duro D,Belissa E,Peytavin G

更新日期：2014-09-01 00:00:00

abstract：:Increases in community-acquired infections caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. We developed and validated a tool for identifying patients harboring these organisms at hospital ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Bassetti M,De Rosa FG,Spanu T,Di Meco E,Losito AR,Parisini A,Pagani N,Cauda R

更新日期：2011-07-01 00:00:00

abstract：:Artemisinin-derivative combination therapies (ACT) are highly efficacious against multidrug-resistant Plasmodium falciparum malaria. Few efficacy data, however, are available for vivax malaria. With high rates of chloroquine (CQ) resistance in both vivax and falciparum malaria in Papua Province, Indonesia, new combina...

journal_title：Antimicrobial agents and chemotherapy

authors： Tjitra E,Baker J,Suprianto S,Cheng Q,Anstey NM

更新日期：2002-12-01 00:00:00

abstract：:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of...

journal_title：Antimicrobial agents and chemotherapy

authors： Espuelas S,Legrand P,Loiseau PM,Bories C,Barratt G,Irache JM

更新日期：2000-08-01 00:00:00

abstract：:Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunell M,Webber MA,Kotilainen P,Lilly AJ,Caddick JM,Jalava J,Huovinen P,Siitonen A,Hakanen AJ,Piddock LJ

更新日期：2009-09-01 00:00:00

abstract：:The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavie J,Lefort A,Ploy MC,Massias L,Chau F,Garry L,Denis F,Fantin B

更新日期：2003-06-01 00:00:00

abstract：:Ciprofloxacin, a fluorinated 4-quinolone, is useful for the clinical treatment of infections due to its antibacterial properties and also modulates the immune response of monocytes isolated from human peripheral blood mononuclear cells. In the present study, we found that ciprofloxacin induced the production of prosta...

journal_title：Antimicrobial agents and chemotherapy

authors： Takahashi HK,Iwagaki H,Xue D,Katsuno G,Sugita S,Mizuno K,Mori S,Saito S,Yoshino T,Tanaka N,Nishibori M

更新日期：2005-08-01 00:00:00