In vitro activities of MK-0826 and 16 other antimicrobials against Bacteroides fragilis group strains.

abstract：:Nemonoxacin (TG-873870) is a novel nonfluorinated quinolone with potent broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens, including vancomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA), quinolone-resistant MRSA, quinolone-resistant Streptococcus pneumoniae, p...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao GY,Zhang J,Zhang YY,Guo BN,Yu JC,Wu XJ,Chen YC,Wu JF,Shi YG

更新日期：2014-10-01 00:00:00

abstract：:Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

更新日期：2012-06-01 00:00:00

abstract：:Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaillard T,Sriprawat K,Briolant S,Wangsing C,Wurtz N,Baragatti M,Lavina M,Pascual A,Nosten F,Pradines B

更新日期：2015-08-01 00:00:00

abstract：:The effectiveness of Staphylococcus aureus strain 8325-4 as a recipient for the transduction of methicillin resistance requires the presence of a penicillinase plasmid but was found to be independent of the lysogenic state of the recipient. Effectiveness is conferred by the plasmid in either the autonomous or integrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Stewart GC,Rosenblum ED

更新日期：1980-09-01 00:00:00

abstract：:An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination o...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Harris B,Carter WT,Finegold SM

更新日期：1985-05-01 00:00:00

abstract：:Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1 gene and the CDR gene family. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. To monitor MDR1 expression under s...

journal_title：Antimicrobial agents and chemotherapy

authors： Harry JB,Oliver BG,Song JL,Silver PM,Little JT,Choiniere J,White TC

更新日期：2005-07-01 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kristiansen BE,Rådström P,Jenkins A,Ask E,Facinelli B,Sköld O

更新日期：1990-11-01 00:00:00

abstract：:A survey conducted between 1987 and 1994 at the University Hospital of Besançon, France, demonstrated a dramatic increase (from 0 to 42. 5%) in the prevalence of amoxicillin resistance among Salmonella spp. Of the 96 resistant isolates collected during this period (including 77 Typhimurium), 54 were found to produce T...

journal_title：Antimicrobial agents and chemotherapy

authors： Llanes C,Kirchgesner V,Plesiat P

更新日期：1999-10-01 00:00:00

abstract：:Invasive and allergic infections by Aspergillus flavus are more common in tropical and subtropical countries. The emergence of voriconazole (VRC) resistance in A. flavus impacts the management of aspergillosis, as azoles are used as the first-line and empirical therapy. We screened 120 molecularly confirmed A. flavus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sharma C,Kumar R,Kumar N,Masih A,Gupta D,Chowdhary A

更新日期：2018-02-23 00:00:00

abstract：:Although antimicrobial agents are effective therapy for early Lyme disease, optimal treatment schedules have not been conclusively established. The efficacy of various dosages of eight antibiotics used for borreliosis treatment was evaluated for C3H/HeNCrIBR mice, which reproducibly develop persistent infection, arthr...

journal_title：Antimicrobial agents and chemotherapy

authors： Moody KD,Adams RL,Barthold SW

更新日期：1994-07-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:The prophylactic efficacy of 17C91, a carbamate prodrug of atovaquone (ATQ), was investigated in a severe combined immunodeficient mouse model of Pneumocystis carinii pneumonia (PCP). At an oral dosage equivalent to 100 mg of ATQ per kg of body weight per day, 17C91 protected 9 of 10 mice from PCP and had a prophylact...

journal_title：Antimicrobial agents and chemotherapy

authors： Comley JC,Yeates CL,Frend TJ

更新日期：1995-10-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:Numerous bacterial pathogens, particularly those that colonize fast-flow areas in the bladder and gastrointestinal tract, require motility to establish infection and spread beyond the initially colonized tissue. Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, e...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen L,White EL,Pathak A,Ayala JC,Wang H,Wu JH,Benitez JA,Silva AJ

更新日期：2011-09-01 00:00:00

abstract：:Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the disease derives from the release of Shiga toxins (Stx). The use of antibiotics t...

journal_title：Antimicrobial agents and chemotherapy

authors： Mühlen S,Ramming I,Pils MC,Koeppel M,Glaser J,Leong J,Flieger A,Stecher B,Dersch P

更新日期：2020-03-24 00:00:00

abstract：:Interactions between bacterial biofilms formed by Pseudomonas aeruginosa and clarithromycin, a macrolide having no anti-P. aeruginosa activity, were investigated. P. aeruginosa incubated for 10 days on membrane filters formed biofilms on the surfaces of the filters. The biofilms were characterized by dense colonizatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yasuda H,Ajiki Y,Koga T,Kawada H,Yokota T

更新日期：1993-09-01 00:00:00

abstract：:To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng KL,Nafziger AN,Peloquin CA,Amsden GW

更新日期：1998-04-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline solution for 1 month, commencing during the early (3 weeks) or chronic (4 months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Hodzic E,Feng S,Holden K,Freet KJ,Barthold SW

更新日期：2008-05-01 00:00:00

abstract：:Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Zarember KA,Cruz AR,Huang CY,Gallin JI

更新日期：2009-06-01 00:00:00

abstract：:We have developed a simple PCR-based high-resolution melt curve analysis for identification of the quinolone resistance gene aac(6')-Ib-cr through regions encompassing the two defining single nucleotide mutations. Dissociation curves showed 100% concordance with DNA sequencing, including the identification of a strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Hidalgo-Grass C,Strahilevitz J

更新日期：2010-08-01 00:00:00

abstract：:Lantibiotics such as nisin (NIS) are peptide antibiotics that may have a role in the chemotherapy of bacterial infections. A perceived benefit of lantibiotics for clinical use is their low propensity to select resistance, although detailed resistance studies with relevant bacterial pathogens are lacking. Here we exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Blake KL,Randall CP,O'Neill AJ

更新日期：2011-05-01 00:00:00

abstract：:Titanium (Ti) is a promising candidate biomaterial for an artificial corneal skirt. Antimicrobial peptide (AMP) immobilization may improve the bactericidal effect of the Ti substrate. In this study, we tested the bactericidal efficacy of a functionalized Ti surface in a rabbit keratitis model. A corneal stromal pocket...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan XW,Goh TW,Saraswathi P,Nyein CL,Setiawan M,Riau A,Lakshminarayanan R,Liu S,Tan D,Beuerman RW,Mehta JS

更新日期：2014-09-01 00:00:00

abstract：:Thein vitroantibacterial activities of ceftazidime-avibactam and comparator agents were evaluated using reference broth microdilution methods against 1,743Pseudomonas aeruginosaisolates collected in 2014 from 69 U.S. medical centers, representing each of the nine census regions. Ceftazidime-avibactam demonstrated pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Huband MD,Castanheira M,Flamm RK,Farrell DJ,Jones RN,Sader HS

更新日期：2016-03-25 00:00:00

abstract：:Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distrib...

journal_title：Antimicrobial agents and chemotherapy

authors： Pai H,Seo MR,Choi TY

更新日期：2007-01-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. After inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-05-01 00:00:00