Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:Twenty-four children with cancer and localized herpes zoster were randomized to receive either topical polyinosinic acid-polycytidylic acid [poly(I:C)] or a saline placebo. Solutions containing 1.0 or 2.5 mg of drug per ml were applied to the lesions every 3 h, seven times a day for 7 consecutive days. Serial, standar...

journal_title：Antimicrobial agents and chemotherapy

authors： Feldman S,Hughes WT,Darlington RW,Kim HK

更新日期：1975-09-01 00:00:00

abstract：:Here, we report the first autochthonous cases of infections caused by blaNDM-5 New Delhi metallo-β-lactamase-producing Escherichia coli strains recovered from urine and blood specimens of three patients from Algeria between January 2012 and February 2013. The three isolates belong to sequence type 2659 and they coexpr...

journal_title：Antimicrobial agents and chemotherapy

authors： Sassi A,Loucif L,Gupta SK,Dekhil M,Chettibi H,Rolain JM

更新日期：2014-09-01 00:00:00

abstract：:Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Ressler R,Wilkins J

更新日期：1974-11-01 00:00:00

abstract：:Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

journal_title：Antimicrobial agents and chemotherapy

authors： El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

更新日期：2015-01-01 00:00:00

abstract：:The rabbit kidney cell line LLC-RK1 was tested for its ability to discriminate the toxicities of six cephalosporin antibiotics according to their in vivo nephrotoxic potentials in rabbits. With the exception of cephalothin, which was markedly toxic to kidney cells in vitro, a good correlation between in vitro toxicity...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams PD,Laska DA,Tay LK,Hottendorf GH

更新日期：1988-03-01 00:00:00

abstract：:Eight unrelated clinical Acinetobacter baumannii isolates resistant to all commonly used antibiotics were subjected to three-dimensional checkerboard microtiter plate dilution and time-kill studies at one-fourth of their MICs of polymyxin B, imipenem, and rifampin. Synergy was demonstrated with combinations of polymyx...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon J,Urban C,Terzian C,Mariano N,Rahal JJ

更新日期：2004-03-01 00:00:00

abstract：:Penicillin-binding protein (PBP) 2 is the major PBP of five that have been identified in susceptible strains of Staphylococcus aureus. Beta-lactam antibiotic binding to PBP 2 is important for the antibacterial effect. Antibiotic binding to PBP 2 in strain 209P was examined with sodium dodecyl sulfate-polyacrylamide ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Miick C

更新日期：1992-03-01 00:00:00

abstract：:Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DCK,Guo I,Burrows LL

更新日期：2020-02-21 00:00:00

abstract：:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Jackowski J,Grant RB

更新日期：1986-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) is the primary etiologic agent responsible for the AIDS pandemic. In this work, we used a chimeric recombinant protein strategy to test the possibility of irreversibly destroying the HIV-1 virion using an agent that simultaneously binds the Env protein and viral membrane. We construc...

journal_title：Antimicrobial agents and chemotherapy

authors： Contarino M,Bastian AR,Kalyana Sundaram RV,McFadden K,Duffy C,Gangupomu V,Baker M,Abrams C,Chaiken I

更新日期：2013-10-01 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:Monobactams containing 3 beta-aminothiazolyl oxime side chains (SQ 81,377, SQ 81,402, azthreonam, and SQ 26,917) have poor affinities for the broad-spectrum beta-lactamases TEM-2 and K1. Addition of a 4-methyl substituent significantly increased stability to hydrolysis by these enzymes. P99 cephalosporinase from Enter...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Freudenberger JS,Sykes RB

更新日期：1982-09-01 00:00:00

abstract：:We report the ultrastructural alterations induced during the proliferative stages of Trypanosoma (Schizotrypanum) cruzi, the causative agent of Chagas' disease, by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, which had previously been shown to be potent growth inhibitors whose effects are pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazardi K,Urbina JA,de Souza W

更新日期：1990-11-01 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:Azithromycin (AZI) is an azalide antibiotic with antimalarial activity that is considered safe in pregnancy. To assess its pharmacokinetic properties when administered as intermittent preventive treatment in pregnancy (IPTp), two 2-g doses were given 24 h apart to 31 pregnant and 29 age-matched nonpregnant Papua New G...

journal_title：Antimicrobial agents and chemotherapy

authors： Salman S,Rogerson SJ,Kose K,Griffin S,Gomorai S,Baiwog F,Winmai J,Kandai J,Karunajeewa HA,O'Halloran SJ,Siba P,Ilett KF,Mueller I,Davis TM

更新日期：2010-01-01 00:00:00

abstract：:Subinhibitory concentrations of antibiotics have been shown to enhance biofilm formation in multiple bacterial species. While antibiotic exposure has been associated with modulated expression of many biofilm-related genes, the mechanisms of drug-induced biofilm formation remain a focus of ongoing research efforts and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu W,Hallinen KM,Wood KB

更新日期：2017-12-21 00:00:00

abstract：:Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Ruzin A,Keeney D,Bradford PA

更新日期：2005-02-01 00:00:00

abstract：:The 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (CMV) challenge in weanling or neonatal mice when administered before virus challenge. This protection was dependent upon the dosage of pyrimidinone administered. Wean...

journal_title：Antimicrobial agents and chemotherapy

authors： Brideau RJ,Wolcott JA

更新日期：1985-10-01 00:00:00

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable ...

journal_title：Antimicrobial agents and chemotherapy

authors： Partridge SR,Thomas LC,Ginn AN,Wiklendt AM,Kyme P,Iredell JR

更新日期：2011-06-01 00:00:00

abstract：:Three Haemophilus parainfluenzae strains isolated from the urogenital tract harbored a beta-lactamase-coding 3.2-megadalton plasmid identical, by restriction endonuclease digestion and hybridization with radioactive and biotin-labeled probes specific for the TEM-1 beta-lactamase and TnA sequences, to the 3.2-megadalto...

journal_title：Antimicrobial agents and chemotherapy

authors： Martel AY,Gosselin P,Ouellette M,Roy PH,Bergeron MG

更新日期：1987-06-01 00:00:00

abstract：:Against 307 pneumococci of various resistotypes, dalbavancin MICs were 0.008 to 0.125 microg/ml. All strains were susceptible to vancomycin, teicoplanin, linezolid, and quinupristin-dalfopristin. Dalbavancin at 2x MIC was bactericidal against all 10 pneumococci tested after 24 h. Vancomycin and teicoplanin killed 10 a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin G,Smith K,Ednie LM,Appelbaum PC

更新日期：2005-12-01 00:00:00

abstract：:Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical stability, and extensive stability against human renal dehydropeptidase-I. Tebipenem is the active form of tebipenem pivoxil, a novel oral carbapenem antibiotic that has a high level of bioavailability...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamada M,Watanabe T,Baba N,Takeuchi Y,Ohsawa F,Gomi S

更新日期：2008-06-01 00:00:00

abstract：:Sulfide production has been proposed to be a universal defense mechanism against antibiotics in bacteria (K. Shatalin, E. Shatalina, A. Mironov, and E. Nudler, Science 334:986-990, 2011, doi:10.1126/science.1209855). To gain insight into the mechanism underlying sulfide protection, we systematically and comparatively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weikum J,Ritzmann N,Jelden N,Klöckner A,Herkersdorf S,Josten M,Sahl HG,Grein F

更新日期：2018-09-24 00:00:00

abstract：:Hand-foot-and-mouth disease (HFMD), caused by enterovirus, is a threat to public health worldwide. To date, enterovirus 71 (EV71) has been one of the major causative agents of HFMD in the Pacific-Asia region, and outbreaks with EV71 cause millions of infections. However, no drug is currently available for clinical the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang Y,Cao L,Zhai Y,Yin Z,Sun Y,Shang L

更新日期：2017-06-27 00:00:00

abstract：:The efficiencies of two dosage schedules of amikacin (2 x 10 mg/kg of body weight per 24 h and 1 x 20 mg/kg/24 h intramuscularly for 5 days) against Pseudomonas aeruginosa sepsis in rabbits were compared. Blood samples were drawn at various times after the first application, and amikacin concentrations in serum were a...

journal_title：Antimicrobial agents and chemotherapy

authors： Staneva M,Markova B,Atanasova I,Terziivanov D

更新日期：1994-05-01 00:00:00

abstract：:Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

更新日期：2020-10-20 00:00:00

abstract：:The pharmacokinetics of cefdinir were investigated in six hemodialysis patients. For the present study, two tests were carried out, one with 4 h of hemodialysis and the other without hemodialysis. Cefdinir was given orally to each patient in a dose of 100 mg, and blood was collected serially for 48 h after dosing in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hishida A,Ohishi K,Nagashima S,Kanamaru M,Obara M,Kitada A

更新日期：1998-07-01 00:00:00