In vitro double and triple synergistic activities of Polymyxin B, imipenem, and rifampin against multidrug-resistant Acinetobacter baumannii.

abstract：:Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol...

journal_title：Antimicrobial agents and chemotherapy

authors： Mayers M,Rush D,Madu A,Motyl M,Miller MH

更新日期：1991-09-01 00:00:00

abstract：:The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Paphitou NI,Ostrosky-Zeichner L,Paetznick VL,Rodriguez JR,Chen E,Rex JH

更新日期：2002-04-01 00:00:00

abstract：:Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as Pseudomonas aeruginosa, Burkholderia multivorans, and Stenotrophomonas maltophilia We previously showed that argyrin B targets elongation factor G (FusA). Here, we show that argyrin B activity against P. aeruginosa PAO1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones AK,Woods AL,Takeoka KT,Shen X,Wei JR,Caughlan RE,Dean CR

更新日期：2017-03-24 00:00:00

abstract：:Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral agent that inhibits ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,Blumer J,O'Riordan MA,Gray W,McKenzie R,Jurao RA,An AT,Le M,Bell SJ,Ochsner UA,Jarvis TC,Janjic N,Zenilman JM

更新日期：2017-07-25 00:00:00

abstract：:The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both species. In dogs, c...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller WM

更新日期：1977-07-01 00:00:00

abstract：:Liquid cultures of a Pseudomonas aeruginosa strain in Mueller-Hinton broth diluted at rates higher than the bacterial growth rate showed the expected decrease in CFU only for 1 to 2 h. Later the CFU started to increase. This phenomenon can be explained by a hypothesis that assumes that the bacteria multiply in two dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Haag R,Lexa P,Werkhäuser I

更新日期：1986-05-01 00:00:00

abstract：:We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters w...

journal_title：Antimicrobial agents and chemotherapy

authors： Keirns J,Sawamoto T,Holum M,Buell D,Wisemandle W,Alak A

更新日期：2007-02-01 00:00:00

abstract：:Staphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hertlein T,Sturm V,Lorenz U,Sumathy K,Jakob P,Ohlsen K

更新日期：2014-01-01 00:00:00

abstract：:A rapid microbiological assay for chlorhydroxyquinoline is described. It is a turbidimetric procedure that uses Streptococcus faecalis as the test organism. Results are available within 5 h. Data are presented to show the advantages of using a cryogenically stored inoculum over an inoculum prepared on a daily basis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cosgrove RF

更新日期：1977-05-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus...

journal_title：Antimicrobial agents and chemotherapy

authors： Gebremariam T,Alkhazraji S,Baldin C,Kovanda L,Wiederhold NP,Ibrahim AS

更新日期：2017-04-24 00:00:00

abstract：:The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation and ultrastructural approaches against Trypanosoma cruzi NPD-008 displayed activity against different forms and strains of T. cruzi (EC50 = 6.6 - 39.5 μM), increased cAMP levels of T. cruzi ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Araújo JS,Peres RB,Bernardino da Silva P,Batista MM,Sterk GJ,Maes L,Caljon G,Leurs R,de Koning HP,Kalejaiye TD,Soeiro MNC

更新日期：2020-12-23 00:00:00

abstract：:Malaria is the third most significant cause of infectious disease in the world. The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to classical drugs. Trioxaquines are synthetic hybrid molecules containing a trioxane motif (which is responsible for the antimalarial a...

journal_title：Antimicrobial agents and chemotherapy

authors： Benoit-Vical F,Lelièvre J,Berry A,Deymier C,Dechy-Cabaret O,Cazelles J,Loup C,Robert A,Magnaval JF,Meunier B

更新日期：2007-04-01 00:00:00

abstract：:Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c alpha Stx2, that h...

journal_title：Antimicrobial agents and chemotherapy

authors： Dowling TC,Chavaillaz PA,Young DG,Melton-Celsa A,O'Brien A,Thuning-Roberson C,Edelman R,Tacket CO

更新日期：2005-05-01 00:00:00

abstract：:Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basic cellular processes of relevance to pathogenic mycobacteria. This study focused on the D-alanine racemase gene (alrA), which is involved in the synthesis of D-alanine, a basic component of peptidoglycan that forms the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chacon O,Feng Z,Harris NB,Cáceres NE,Adams LG,Barletta RG

更新日期：2002-01-01 00:00:00

abstract：:Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases, this is catalyzed by flavin mononucleotide (FMN)-dependent type I nitroreductases (NTRs), a class of enzyme absent from higher eukaryotes but expressed by bacteria and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Seifert K,Helsby NA,Wilkinson SR

更新日期：2014-01-01 00:00:00

abstract：:Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new assay system in agar plates, the radial diffusion assay, to evaluate the effects of human defensins against gram-positive...

journal_title：Antimicrobial agents and chemotherapy

authors： Takemura H,Kaku M,Kohno S,Hirakata Y,Tanaka H,Yoshida R,Tomono K,Koga H,Wada A,Hirayama T,Kamihira S

更新日期：1996-10-01 00:00:00

abstract：:Morinidazole, a 5-nitroimidazole antimicrobial drug, has been approved for the treatment of amoebiasis, trichomoniasis, and anaerobic bacterial infections in China. It was reported that drug-drug interaction happened after the coadministration of ornidazole, an analog of morinidazole, and rifampin or ketoconazole. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Pang X,Zhang Y,Gao R,Zhong K,Zhong D,Chen X

更新日期：2014-10-01 00:00:00

abstract：:Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye KS,Cosgrove S,Harris A,Eliopoulos GM,Carmeli Y

更新日期：2001-09-01 00:00:00

abstract：:The effect of ethambutol (EMB) is primarily on polymerization steps in the biosynthesis of the arabinan component of cell wall arabinogalactan (AG) of Mycobacterium smegmatis. Inhibition of the synthesis of the arabinan of lipoarabinomannan (LAM) occurred later, and thus in the cases of AG and LAM, the polymerization ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikusová K,Slayden RA,Besra GS,Brennan PJ

更新日期：1995-11-01 00:00:00

abstract：:The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore a...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Bugg TD,Wright GD,Walsh CT,Courvalin P

更新日期：1992-04-01 00:00:00

abstract：:The class 1 integron In28, found in the multidrug resistance transposon Tn1403, was found to be located in the res site of the backbone transposon and is flanked by a 5-bp direct duplication, indicating that it reached this position by transposition. In28 has a backbone structure related to that of In4, but has lost i...

journal_title：Antimicrobial agents and chemotherapy

authors： Partridge SR,Recchia GD,Stokes HW,Hall RM

更新日期：2001-11-01 00:00:00

abstract：:Genes belonging to different erm DNA hybridization classes were selectively amplified by polymerase chain reaction with a pair of oligonucleotides that corresponded to conserved amino acid motifs in known ERM methylases. Identification of the resistance mechanism was possible despite substantial nucleotide sequence di...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Mabilat C,Courvalin P

更新日期：1990-10-01 00:00:00

abstract：:The gene coding for aminoglycoside 2'-N-acetyltransferase Ia [AAC(2')-Ia] from Providencia stuartii was amplified by PCR and cloned. The resulting construct, pACKF2, was transferred into Escherichia coli for overexpression of AAC(2')-Ia as a fusion protein with an N-terminal hexa-His tag. The fusion protein was isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Franklin K,Clarke AJ

更新日期：2001-08-01 00:00:00

abstract：:Lupeol, which shows in vitro inhibitory activity against Plasmodium falciparum 3D7 strain with a 50% inhibitory concentration (IC50) of 27.7 +/- 0.5 microM, was shown to cause a transformation of the human erythrocyte shape toward that of stomatocytes. Good correlation between the IC50 value and the membrane curvature...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziegler HL,Staerk D,Christensen J,Hviid L,Hägerstrand H,Jaroszewski JW

更新日期：2002-05-01 00:00:00

abstract：:The in vitro effects of 19 dicationic diamidine derivatives against the proliferative tachyzoite stages of the apicomplexan parasites Neospora caninum and Toxoplasma gondii were investigated. Four compounds (DB811, DB786, DB750, and DB766) with similar structural properties exhibited profound inhibition of tachyzoite ...

journal_title：Antimicrobial agents and chemotherapy

authors： Leepin A,Stüdli A,Brun R,Stephens CE,Boykin DW,Hemphill A

更新日期：2008-06-01 00:00:00

abstract：:This work investigated the molecular events driving the evolution of the CTX-M-type β-lactamases by the use of DNA shuffling of fragments of the blaCTX-M-14 and blaCTX-M-15 genes. Analysis of a total of 51 hybrid enzymes showed that enzymatic activity could be maintained in most cases, yet hybrids that were active pos...

journal_title：Antimicrobial agents and chemotherapy

authors： Po KHL,Chan EWC,Chen S

更新日期：2017-11-22 00:00:00

abstract：:Single-dose nevirapine (sd-NVP) and extended NVP prophylaxis are widely used in resource-constrained settings to prevent vertical HIV-1 transmission. We assessed the pharmacokinetics of sd-NVP in 62 HIV-1-positive pregnant Ugandan woman and their newborns who were receiving sd-NVP prophylaxis to prevent mother-to-chil...

journal_title：Antimicrobial agents and chemotherapy

authors： Frank M,von Kleist M,Kunz A,Harms G,Schütte C,Kloft C

更新日期：2011-12-01 00:00:00

abstract：:A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 50% inhibitory conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Severin A,Chopra R,Krishnamurthy G,Singh G,Hu W,Keeney D,Svenson K,Petersen PJ,Labthavikul P,Shlaes DM,Rasmussen BA,Failli AA,Shumsky JS,Kutterer KM,Gilbert A,Mansour TS

更新日期：2006-02-01 00:00:00