Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region.

abstract：:Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

journal_title：Antimicrobial agents and chemotherapy

authors： Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

更新日期：2017-03-24 00:00:00

abstract：:Temafloxacin, a new fluoroquinolone, alone or in combination with tobramycin, was compared with penicillin, tobramycin, and their combination in the therapy of rabbits with endocarditis caused by Streptococcus adjacens GaDT, a new species of nutritionally variant streptococci. Animals were injected intramuscularly for...

journal_title：Antimicrobial agents and chemotherapy

authors： Cremieux AC,Saleh-Mghir A,Vallois JM,Maziere B,Muffat-Joly M,Devine C,Bouvet A,Pocidalo JJ,Carbon C

更新日期：1992-10-01 00:00:00

abstract：:Amphotericin B colloidal dispersion (ABCD) is a new formulation of conventional amphotericin B designed to minimize drug distribution in the kidney and reduce nephrotoxicity. We studied the safety and efficacy of ABCD in 133 renally compromised patients with invasive fungal infections. Patients had either nephrotoxici...

journal_title：Antimicrobial agents and chemotherapy

authors： Anaissie EJ,Mattiuzzi GN,Miller CB,Noskin GA,Gurwith MJ,Mamelok RD,Pietrelli LA

更新日期：1998-03-01 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Dudley MN,Nightingale CH,Drezner AD,Low HB,Quintiliani R

更新日期：1984-09-01 00:00:00

abstract：:An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on the MIC(90) of 0.06 microg/ml for Streptococcus pyogenes reported in the literature) was shown to be achievable in a phase 1 study of 23 children with a once-daily (QD) modified-release, multiparticulate formul...

journal_title：Antimicrobial agents and chemotherapy

authors： Pichichero ME,Casey JR,Block SL,Guttendorf R,Flanner H,Markowitz D,Clausen S

更新日期：2008-07-01 00:00:00

abstract：:Polyclonal antibodies elicited by injection into rabbits of a nystatin-bovine serum albumin conjugate were reactive with both nystatin and amphotericin B. Upon labeling of polyene-treated Saccharomyces cerevisiae sterol auxotrophs grown on various sterols, nystatin reacted specifically with ergosterol, while amphoteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker-Caprioglio HM,MacKenzie JM,Parks LW

更新日期：1989-12-01 00:00:00

abstract：:The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hennequin C,Benailly N,Silly C,Sorin M,Scheinmann P,Lenoir G,Gaillard JL,Berche P

更新日期：1997-09-01 00:00:00

abstract：:Pipemidic acid was absorbed well by the oral route. Its peak levels in plasma ranged from 4 to 12 mug/ml at an oral dose of about 50 mg/kg in mice, rats, dogs, monkeys, and men. The protein binding of pipemidic acid was about 20% in dog plasma and about 30% in human serum. Pipemidic acid was distributed to most of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimizu M,Nakamura S,Takase Y,Kurobe N

更新日期：1975-04-01 00:00:00

abstract：:Noninferiority trial design and analyses are commonly used to establish the effectiveness of a new antimicrobial drug for treatment of serious infections such as complicated urinary tract infection (cUTI). A systematic review and meta-analysis were conducted to estimate the treatment effects of three potential active ...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh KP,Li G,Mitrani-Gold FS,Kurtinecz M,Wetherington J,Tomayko JF,Mundy LM

更新日期：2013-11-01 00:00:00

abstract：:Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 μg/ml but not among isolates with MICs of ≤ 0.032 μg/ml. Experimental infection of cipr...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong E,Thulin Hedberg S,Abad R,Fazio C,Enríquez R,Deghmane AE,Jolley KA,Stefanelli P,Unemo M,Vazquez JA,Veyrier FJ,Taha MK

更新日期：2013-04-01 00:00:00

abstract：:Faldaprevir is a potent hepatitis C virus (HCV) NS3/4A protease inhibitor with negligible urinary excretion. We assessed the pharmacokinetics and safety of a single oral dose of faldaprevir (480 mg) in 32 HCV-negative subjects with renal impairment or normal renal function. Compared with subjects with normal renal fun...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang F,Moschetti V,Lang B,Halabi A,Petersen-Sylla M,Yong CL,Elgadi M

更新日期：2015-01-01 00:00:00

abstract：:The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

更新日期：2011-09-01 00:00:00

abstract：:The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pathway is indispensable for Chlamydia growth. Previously, a high-conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Mojica SA,Salin O,Bastidas RJ,Sunduru N,Hedenström M,Andersson CD,Núñez-Otero C,Engström P,Valdivia RH,Elofsson M,Gylfe Å

更新日期：2017-09-22 00:00:00

abstract：:Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozano S,Gamallo P,González-Cortés C,Presa Matilla JL,Fairhurst RM,Herreros E,Amaratunga C,Rodrigues J

更新日期：2018-11-26 00:00:00

abstract：:Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeannot K,Poirel L,Robert-Nicoud M,Cholley P,Nordmann P,Plésiat P

更新日期：2012-04-01 00:00:00

abstract：:The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hobbie SN,Pfister P,Brüll C,Westhof E,Böttger EC

更新日期：2005-12-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore a...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Bugg TD,Wright GD,Walsh CT,Courvalin P

更新日期：1992-04-01 00:00:00

abstract：:During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. Possible mechanisms underlying this...

journal_title：Antimicrobial agents and chemotherapy

authors： Schurek KN,Sampaio JL,Kiffer CR,Sinto S,Mendes CM,Hancock RE

更新日期：2009-10-01 00:00:00

abstract：:Susceptibilities of 121 clinical Helicobacter pylori strains to metronidazole were determined by both a 5-micrograms metronidazole disk diffusion test and a plate dilution method in duplicate and after different periods of incubation. The distribution of MICs of metronidazole against H. pylori among the strains was fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Xia H,Keane CT,Beattie S,O'Morain CA

更新日期：1994-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was n...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Stevens DA

更新日期：1991-10-01 00:00:00

abstract：:Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious top...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti S,Cevini C,Bruno A,Penso G,Rama P,Scaglia M

更新日期：1998-09-01 00:00:00

abstract：:Pseudomonas aeruginosa infection in ventilator-associated pneumonia is a serious and often life-threatening complication in intensive care unit patients, and new treatment options are needed. We used B-cell-enriched peripheral blood lymphocytes from a volunteer immunized with a P. aeruginosa O-polysaccharide-toxin A c...

journal_title：Antimicrobial agents and chemotherapy

authors： Horn MP,Zuercher AW,Imboden MA,Rudolf MP,Lazar H,Wu H,Hoiby N,Fas SC,Lang AB

更新日期：2010-06-01 00:00:00

abstract：:We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal menin...

journal_title：Antimicrobial agents and chemotherapy

authors： Egermann U,Stanga Z,Ramin A,Acosta F,Stucki A,Gerber P,Cottagnoud M,Cottagnoud P

更新日期：2009-07-01 00:00:00

abstract：:The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreas...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Mellado E,Díaz-Guerra TM,Monzón A,Rodríguez-Tudela JL

更新日期：2001-06-01 00:00:00

abstract：:Aspergillus fumigatus is a leading cause of death in immunocompromised patients and a frequent colonizer of the respiratory tracts of asthma and cystic fibrosis (CF) patients. Biofilms enable bacteria and yeasts to persist in infections and can contribute to antimicrobial resistance. We investigated the ability of A. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seidler MJ,Salvenmoser S,Müller FM

更新日期：2008-11-01 00:00:00