Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11.

abstract：:Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserv...

journal_title：Antimicrobial agents and chemotherapy

authors： Hölzel CS,Harms KS,Schwaiger K,Bauer J

更新日期：2010-03-01 00:00:00

abstract：:Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiskirchen DE,Nordmann P,Crandon JL,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:A comparison of the daclatasvir (DCV [BMS-790052]) resistance barrier on authentic or hybrid replicons containing NS5A from hepatitis C virus (HCV) genotypes 1 to 6 (GT-1 to -6) was completed using a replicon elimination assay. The data indicated that genotype 1b (GT-1b) has the highest relative resistance barrier and...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang C,Jia L,O'Boyle DR 2nd,Sun JH,Rigat K,Valera L,Nower P,Huang X,Kienzle B,Roberts S,Gao M,Fridell RA

更新日期：2014-09-01 00:00:00

abstract：:Francisella tularensis, a bacterium which causes tularemia in humans, is classified as a CDC category A bioterrorism agent. In this study, we demonstrate that celecoxib, an anti-inflammatory cyclooxygenase-2 inhibitor in clinical use, exhibits activity against a type A strain of F. tularensis (Schu S4), the live vacci...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiu HC,Yang J,Soni S,Kulp SK,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-07-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:To compare the effect of ritonavir on plasma amprenavir pharmacokinetics, healthy adults received either fosamprenavir (700 mg twice a day [BID]) or amprenavir (600 mg BID) alone and in combination with ritonavir (100 mg BID). Ritonavir increased plasma amprenavir pharmacokinetic parameters to a similar extent when co...

journal_title：Antimicrobial agents and chemotherapy

authors： Wire MB,Baker KL,Jones LS,Shelton MJ,Lou Y,Thomas GJ,Berrey MM

更新日期：2006-04-01 00:00:00

abstract：:Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the disease derives from the release of Shiga toxins (Stx). The use of antibiotics t...

journal_title：Antimicrobial agents and chemotherapy

authors： Mühlen S,Ramming I,Pils MC,Koeppel M,Glaser J,Leong J,Flieger A,Stecher B,Dersch P

更新日期：2020-03-24 00:00:00

abstract：:The linkage between the macrolide efflux gene mef(I) and the chloramphenicol inactivation gene catQ was first described in Streptococcus pneumoniae (strain Spn529), where the two genes are located in a module designated IQ element. Subsequently, two different defective IQ elements were detected in Streptococcus pyogen...

journal_title：Antimicrobial agents and chemotherapy

authors： Mingoia M,Morici E,Morroni G,Giovanetti E,Del Grosso M,Pantosti A,Varaldo PE

更新日期：2014-10-01 00:00:00

abstract：:The effect of 19 antimicrobial agents on human polymorphonuclear leukocyte function was evaluated by chemiluminescence assays, yeast phagocytosis and killing, and lactate dehydrogenase release. Tetracycline and trimethoprim inhibited chemiluminescence and reduced killing at therapeutic concentrations of 2 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Welch WD,Davis D,Thrupp LD

更新日期：1981-07-01 00:00:00

abstract：:The K70E mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has become more prevalent in clinical samples, particularly in isolates derived from patients for whom triple-nucleoside regimens that include tenofovir (TNV), abacavir, and lamivudine (3TC) failed. To elucidate the molecular m...

journal_title：Antimicrobial agents and chemotherapy

authors： Sluis-Cremer N,Sheen CW,Zelina S,Torres PS,Parikh UM,Mellors JW

更新日期：2007-01-01 00:00:00

abstract：:The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreas...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Mellado E,Díaz-Guerra TM,Monzón A,Rodríguez-Tudela JL

更新日期：2001-06-01 00:00:00

abstract：:The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis. In vitro studies were performed with MRC5 fibroblast tissue cultures, with quantification of Toxoplasma growth by an enzyme-linked immunosor...

journal_title：Antimicrobial agents and chemotherapy

authors： Romand S,Pudney M,Derouin F

更新日期：1993-11-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00

abstract：:Gatifloxacin is an 8-methoxy fluoroquinolone effective against a broad spectrum of pathogens common in pediatric infections. The safety and pharmacokinetics of a single dose of gatifloxacin were studied in pediatric patients from 6 months to 16 years of age. Seventy-six pediatric patients (average age, 6.7 +/- 5.0 yea...

journal_title：Antimicrobial agents and chemotherapy

authors： Capparelli EV,Reed MD,Bradley JS,Kearns GL,Jacobs RF,Damle BD,Blumer JL,Grasela DM

更新日期：2005-03-01 00:00:00

abstract：:The epidemiology of the two common erythromycin resistance methylase (erm) genes ermA and ermC was analyzed by Southern blotting in 428 erythromycin-resistant Staphylococcus aureus strains isolated from blood between 1959 and 1988 in Denmark. ermA and/or ermC was present in 98% of the erythromycin-resistant strains te...

journal_title：Antimicrobial agents and chemotherapy

authors： Westh H,Hougaard DM,Vuust J,Rosdahl VT

更新日期：1995-02-01 00:00:00

abstract：:We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and their penicillin-derived components. Bactericidal activity was assayed and morpholo...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Cherubin CE

更新日期：1991-09-01 00:00:00

abstract：:Various doses of amphotericin B encapsulated into unilamellar vesicles of 0.1 micron diameter (lip-AMB) (1.0 to 20.0 mg/kg of body weight) were compared with free amphotericin B (AMB) (0.5 to 2.0 mg/kg of body weight) in a murine model of disseminated candidiasis. CD2F1 mice injected intravenously with 3 x 10(5) Candi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gondal JA,Swartz RP,Rahman A

更新日期：1989-09-01 00:00:00

abstract：:Both ampicillin and cefuroxime therapy of neonates selected drug- and species-dependent beta-lactam resistance patterns in fecal strains of Escherichia coli and Klebsiella spp. This was in contrast to our previous findings that ampicillin, but not cefuroxime, contributed to the emergence of beta-lactam resistance also...

journal_title：Antimicrobial agents and chemotherapy

authors： Tullus K,Berglund B,Burman LG

更新日期：1990-02-01 00:00:00

abstract：:Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Asculai SS,Weis MT,Rancourt MW,Kupferberg AB

更新日期：1978-04-01 00:00:00

abstract：:Generation of pharmacodynamic relationships in the clinical arena requires estimation of pharmacokinetic parameter values for individual patients. When the target population is severely ill, the ability to obtain traditional intensive blood sampling schedules is curtailed. Population modeling guided by optimal samplin...

journal_title：Antimicrobial agents and chemotherapy

authors： Tam VH,Preston SL,Drusano GL

更新日期：2003-09-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes serious illness (lower respiratory illness) in preterm infants. RSV antibody-enriched immunoglobulin (RSVIG) that was lyophilized (LYO) protected against RSV lower respiratory illness. The Food and Drug Administration now requires an additional viral inactivation step (VI). We ...

journal_title：Antimicrobial agents and chemotherapy

authors： Groothuis JR,Simoes EA,Lehr MV,Kramer AA,Hemming VG,Rodriguez WJ,Arrobio J,Welliver RC,Siber GR

更新日期：1995-03-01 00:00:00

abstract：:We compared the kinetics of amphotericin B (AMB) lung accumulation and fungal clearance by liposomal amphotericin B (L-AMB) and amphotericin B lipid complex (ABLC) in a neutropenic murine model of invasive pulmonary mucormycosis (IPM). Immunosuppressed BALB/c mice were inoculated with 1 x 10(6) Rhizopus oryzae spores ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis RE,Albert ND,Liao G,Hou J,Prince RA,Kontoyiannis DP

更新日期：2010-03-01 00:00:00

abstract：:Antimicrobial liquids and foams were applied to the hands to determine their virucidal activity against rhinoviruses. Dilute solutions (1%) of iodine in ethyl alcohol or in water were most effective in causing inactivation of rhinovirus when applied immediately after viral contamination. Iodine also had a residual vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Hendley JO,Mika LA,Gwaltney JM Jr

更新日期：1978-11-01 00:00:00

abstract：:A case-control study of the effect of antiretroviral therapy (ART) on apoptosis pathway genes comprising 16 cases (HIV infected with mitochondrial toxicity) and 16 controls (HIV uninfected) was conducted. A total of 26 of 84 genes of the apoptosis pathway were differentially expressed. Two of the upregulated genes, DF...

journal_title：Antimicrobial agents and chemotherapy

authors： Foli Y,Ghebremichael M,Li M,Paintsil E

更新日期：2017-07-25 00:00:00

abstract：:A plant pathogenic actinomycete identified as Streptomyces lydicus was isolated from the deep-pitted scab lesions of potato tubers. This strain produces a new polypeptide antibiotic named chandramycin. The antibiotic was isolated from culture broth by extraction with organic solvents and purified by chromatography. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh SK,Gurusiddaiah S

更新日期：1984-09-01 00:00:00

abstract：:Candida albicans and Staphylococcus aureus form vigorous polymicrobial biofilms in serum, which may serve as the source of coinfection in patients. More importantly, S. aureus is highly resistant to vancomycin during polymicrobial biofilm formation, with no decreases in bacterial viability observed with up to 1,600 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2010-09-01 00:00:00

abstract：:Subinhibitory concentrations of antibiotics have been shown to enhance biofilm formation in multiple bacterial species. While antibiotic exposure has been associated with modulated expression of many biofilm-related genes, the mechanisms of drug-induced biofilm formation remain a focus of ongoing research efforts and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu W,Hallinen KM,Wood KB

更新日期：2017-12-21 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:Cefmenoxime, an investigational semisynthetic cephalosporin, was evaluated in 18 pediatric patients with a variety of infections. There were seven patients with urinary tract infections, two with wound infections, two with osteomyelitis, two with abscess infections, one with cervical adenitis, one with hidradenitis, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Tansino GF,Hammerschlag MR,Congeni BL,Cox PA,Doraiswamy B,duBouchet L

更新日期：1985-10-01 00:00:00