Production, purification, and characterization of chandramycin, a polypeptide antibiotic from Streptomyces lydicus.

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:The resistome of P. aeruginosa for three β-lactam antibiotics, namely, ceftazidime, imipenem, and meropenem, was deciphered by screening a comprehensive PA14 mutant library for mutants with increased or reduced susceptibility to these antimicrobials. Confirmation of the phenotypes of all selected mutants was performed...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez-Ortega C,Wiegand I,Olivares J,Hancock RE,Martínez JL

更新日期：2010-10-01 00:00:00

abstract：:We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka R,Hanabusa H,Kinai E,Hasegawa N,Negishi M,Kato S

更新日期：2008-02-01 00:00:00

abstract：:Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-beta-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within C...

journal_title：Antimicrobial agents and chemotherapy

authors： Villegas MV,Lolans K,del Rosario Olivera M,Suarez CJ,Correa A,Queenan AM,Quinn JP,Colombian Nosocomial Resistance Study Group.

更新日期：2006-01-01 00:00:00

abstract：:During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible phenotype in which skipped wells were observed during broth microdilution testing for polymyxin B. Possible mechanisms underlying this...

journal_title：Antimicrobial agents and chemotherapy

authors： Schurek KN,Sampaio JL,Kiffer CR,Sinto S,Mendes CM,Hancock RE

更新日期：2009-10-01 00:00:00

abstract：:Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefor...

journal_title：Antimicrobial agents and chemotherapy

authors： Berke JM,Vijgen L,Lachau-Durand S,Powdrill MH,Rawe S,Sjuvarsson E,Eriksson S,Götte M,Fransen E,Dehertogh P,Van den Eynde C,Leclercq L,Jonckers TH,Raboisson P,Nilsson M,Samuelsson B,Rosenquist Å,Fanning GC,Lin TI

更新日期：2011-08-01 00:00:00

abstract：:We investigated the relationship between susceptibility to beta-lactam antibiotics and variation in the major outer membrane protein P2 (OmpP2; also called porin) of persistent nonencapsulated Haemophilus influenzae isolated from cystic fibrosis patients. Nine OmpP2 variants were selected from two distinct H. influenz...

journal_title：Antimicrobial agents and chemotherapy

authors： Regelink AG,Dahan D,Möller LV,Coulton JW,Eijk P,Van Ulsen P,Dankert J,Van Alphen L

更新日期：1999-02-01 00:00:00

abstract：:We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxici...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura M,Kunimoto S,Takahashi Y,Naganawa H,Sakaue M,Inoue S,Ohno T,Takeuchi T

更新日期：1992-02-01 00:00:00

abstract：:Population distributions and quality control data for strains of Pseudomonas aeruginosa tested for gentamicin susceptibility on six lots of Mueller-Hinton agar were analyzed. The lots of agar were used in three University of Washington hospitals from April 1975 through October 1977. The analyses indicated that the per...

journal_title：Antimicrobial agents and chemotherapy

authors： Pollock HM,Minshew BH,Kenny MA,Schoenknecht FD

更新日期：1978-09-01 00:00:00

abstract：:The in vitro activities of four fluoroquinolone compounds were tested against 92 Escherichia coli strains of ovine and caprine origin under aerobic and anaerobic incubation conditions. The four fluoroquinolones proved to be highly effective against the E. coli isolates tested. When bacteria were cultured anaerobically...

journal_title：Antimicrobial agents and chemotherapy

authors： Cid D,Piriz S,Ruiz-Santa-Quiteria JA,Valle J,Garcia S,Vadillo S,de la Fuente R

更新日期：1994-10-01 00:00:00

abstract：:There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

journal_title：Antimicrobial agents and chemotherapy

authors： Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

更新日期：2020-09-21 00:00:00

abstract：:Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention tri...

journal_title：Antimicrobial agents and chemotherapy

authors： Polhemus ME,Remich S,Ogutu B,Waitumbi J,Lievens M,Ballou WR,Heppner DG Jr

更新日期：2008-04-01 00:00:00

abstract：:In order to establish a screening system for xenosiderophores which can be utilized by mycobacteria, we generated a set of mutants of Mycobacterium smegmatis that are blocked in different steps of the well-known iron acquisition system. One mutant with a block in mycobactin biosynthesis was generated from strain mc(2)...

journal_title：Antimicrobial agents and chemotherapy

authors： Schumann G,Möllmann U

更新日期：2001-05-01 00:00:00

abstract：:Ten (0.05%) of 18,628 strains of Streptococcus pyogenes isolated from clinical specimens in the 3 years 1968 to 1970 were resistant to lincomycin and erythromycin. All 10 strains were highly resistant to lincomycin, having minimal inhibitory concentration (MIC) values of 200 mug/ml. There were two degrees of resistanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon JM,Lipinski AE

更新日期：1972-04-01 00:00:00

abstract：:The need for daily parenteral administration is an important limitation in the clinical use of pentavalent antimonial drugs against leishmaniasis. In this study, amphiphilic antimony(V) complexes were prepared from alkylmethylglucamides (L8 and L10, with carbon chain lengths of 8 and 10, respectively), and their poten...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes FR,Ferreira WA,Campos MA,Ramos GS,Kato KC,Almeida GG,Corrêa JD Junior,Melo MN,Demicheli C,Frézard F

更新日期：2013-09-01 00:00:00

abstract：:Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlstrom CA,Ramey AM,Woksepp H,Bonnedahl J

更新日期：2019-07-25 00:00:00

abstract：:The aim of this open-label, fixed-sequence study was to investigate the potential of the botanical supplement Echinacea purpurea to interact with etravirine, a nonnucleoside reverse transcriptase inhibitor of HIV. Fifteen HIV-infected patients receiving antiretroviral therapy with etravirine (400 mg once daily) for at...

journal_title：Antimicrobial agents and chemotherapy

authors： Moltó J,Valle M,Miranda C,Cedeño S,Negredo E,Clotet B

更新日期：2012-10-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:Miloxacin, a synthetic antibacterial agent structurally related to oxolinic acid, has a broad spectrum of activity in vitro against gram-negative bacteria and considerable activity in vivo against infections with these bacteria. These observations led to studies on the absorption and excretion of miloxacin in mice, ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Izawa A,Yoshitake A,Komatsu T

更新日期：1980-07-01 00:00:00

abstract：:In vitro surveys of antimicrobial resistance among clinically important anaerobes are an important source of information that can be used for clinical decisions in the choice of empiric antimicrobial therapy. This study surveyed the susceptibilities of 556 clinical anaerobic isolates from four large medical centers us...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft D,Cambre K,Pierson CL,Jenkins SG,Rosenblatt JE

更新日期：2001-04-01 00:00:00

abstract：:Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

journal_title：Antimicrobial agents and chemotherapy

authors： Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

更新日期：2016-03-25 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Sixty-three consecutive streptococcal blood isolates from neutropenic patients, represented mainly by viridans group streptococci, were evaluated in vitro for antibiotic susceptibility. Of these isolates, 79.3% were highly susceptible to penicillin (MIC, less than or equal to 0.12 microgram/ml). Overall, imipenem was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venditti M,Baiocchi P,Santini C,Brandimarte C,Serra P,Gentile G,Girmenia C,Martino P

更新日期：1989-04-01 00:00:00

abstract：:Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuksa M,Krajden S,Lee A

更新日期：1984-09-01 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:Antibiotic therapy is the most commonly used strategy to control pathogenic infections; however, it has contributed to the generation of antibiotic-resistant bacteria. To circumvent this emerging problem, we are searching for compounds that target bacterial virulence factors rather than their viability. Pseudomonas ae...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamazaki A,Li J,Zeng Q,Khokhani D,Hutchins WC,Yost AC,Biddle E,Toone EJ,Chen X,Yang CH

更新日期：2012-01-01 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:Cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. Cefamandole had activity equivalent to cefazolin against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae. Cefamandole was more active than cephalothin or cefazo...

journal_title：Antimicrobial agents and chemotherapy

authors： Shemonsky NK,Carrizosa J,Levison ME

更新日期：1975-12-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00