Selection of orally active antifungal agents from 3,5-substituted isoxazolidine derivatives based on acute efficacy-safety profiles.

abstract：:We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme i...

journal_title：Antimicrobial agents and chemotherapy

authors： Moriyama B,Elinoff J,Danner RL,Gea-Banacloche J,Pennick G,Rinaldi MG,Walsh TJ

更新日期：2009-04-01 00:00:00

abstract：:Nalidixic acid-resistant derivatives of Neisseria gonorrhoeae WR302 were identified and categorized into two classes on the basis of their susceptibilities to this antimicrobial agent. The MIC of nalidixic acid for the derivative strain MUG116 was fourfold greater than that for its isogenic parental strain WR302 (2 ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Stein DC,Danaher RJ,Cook TM

更新日期：1991-04-01 00:00:00

abstract：:We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel R,Uhl JR,Kohner P,Hopkins MK,Steckelberg JM,Kline B,Cockerill FR 3rd

更新日期：1998-01-01 00:00:00

abstract：:The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and uri...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonapace CR,White RL,Friedrich LV,Norcross ED,Bosso JA

更新日期：1999-12-01 00:00:00

abstract：:There is an increasing need for novel drugs and new strategies for the therapy of invasive candidiasis. This study aimed to develop and characterize liposome-based nanoparticles of carvacrol, cinnamaldehyde, citral or thymol with anti-Candida activities. Dioctadecyldimethylammonium bromide- and monoolein-based liposom...

journal_title：Antimicrobial agents and chemotherapy

authors： Miranda-Cadena K,Dias M,Costa-Barbosa A,Collins T,Marcos-Arias C,Eraso E,Pais C,Quindós G,Sampaio P

更新日期：2021-01-19 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:The effects of probenecid on the pharmacokinetics and renal clearance of acyclovir were studied in humans. Acyclovir (5 mg/kg) was given as a 1-h infusion to three volunteers with normal renal function both before and after oral administration of probenecid (1 g). The kinetics were well described by a two-compartment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Laskin OL,de Miranda P,King DH,Page DA,Longstreth JA,Rocco L,Lietman PS

更新日期：1982-05-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetics of cefprozil were determined with 12 volunteers (8 received cefprozil and 4 received a placebo) after oral administration of 500 mg every 12 h over an 8-day period in a randomized, double-blind, placebo-controlled design. Concentrations in serum and urine were measured by high-pressure liquid chro...

journal_title：Antimicrobial agents and chemotherapy

authors： Lode H,Müller C,Borner K,Nord CE,Koeppe P

更新日期：1992-01-01 00:00:00

abstract：:Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close relative of N. fowleri, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarink MJ,Tielens AGM,Verbon A,Sutak R,van Hellemond JJ

更新日期：2020-07-22 00:00:00

abstract：:Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosin...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Helgstrand E,Johansson NG,Larsson A,Misiorny A,Norén JO,Philipson L,Stenberg K,Stening G,Stridh S,Oberg B

更新日期：1977-06-01 00:00:00

abstract：:Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

更新日期：2013-11-01 00:00:00

abstract：:Bacteriolytic antibiotics cause the release of bacterial components that augment the host inflammatory response, which in turn contributes to the pathophysiology of brain injury in bacterial meningitis. In the present study, antibiotic therapy with nonbacteriolytic daptomycin was compared with that of bacteriolytic ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Grandgirard D,Schürch C,Cottagnoud P,Leib SL

更新日期：2007-06-01 00:00:00

abstract：:The Capnocytophaga sputigena isolate NOR, responsible for septicemia, was resistant to amoxicillin and narrow-spectrum cephalosporins. In a cloning experiment, a new gene, bla(CSP-1), was identified; this gene encodes a novel extended-spectrum beta-lactamase (ESBL) that shares only 52% and 49% identities with the CME-...

journal_title：Antimicrobial agents and chemotherapy

authors： Guillon H,Eb F,Mammeri H

更新日期：2010-05-01 00:00:00

abstract：:The three direct-acting antiviral agent (3D) regimen is a novel combination of direct-acting antiviral agents (DAAs) that has proven effective for the treatment of hepatitis C virus (HCV) infection. Given the potential for coadministration in patients with human immunodeficiency virus infection, possible drug interact...

journal_title：Antimicrobial agents and chemotherapy

authors： Khatri A,Dutta S,Dunbar M,Podsadecki T,Trinh R,Awni W,Menon R

更新日期：2016-04-22 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:In a dose-ranging study of amprenavir (formerly 141W94), an inhibitor of the protease enzyme of human immunodeficiency virus (HIV) type 1, single-dose and steady-state pharmacokinetic parameters were estimated from plasma samples collected on day 1 and during week 3, respectively. Amprenavir was administered on either...

journal_title：Antimicrobial agents and chemotherapy

authors： Sadler BM,Gillotin C,Lou Y,Stein DS

更新日期：2001-01-01 00:00:00

abstract：:CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase, was derived by mutagenesis. The hydrolytic efficiency of CMY-30 against expanded-spectrum cephalosporins was higher than that of CMY-2 due to increased k(cat) values. Findings indicate a role of the Omega loop residue 211 in determining the substrate specificities ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kotsakis SD,Papagiannitsis CC,Tzelepi E,Tzouvelekis LS,Miriagou V

更新日期：2009-08-01 00:00:00

abstract：:Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaka M,Jaturapat A,Kramyu J,Tanticharoen M,Thebtaranonth Y

更新日期：2002-04-01 00:00:00

abstract：:An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region w...

journal_title：Antimicrobial agents and chemotherapy

authors： Janvier F,Jeannot K,Tessé S,Robert-Nicoud M,Delacour H,Rapp C,Mérens A

更新日期：2013-07-01 00:00:00

abstract：:The effect of tryptophan-N-formylated gramicidin (NFG) on the growth of Plasmodium berghei in mice was tested in three different experiments. NFG was shown to be capable of inhibiting the growth of the parasite in a dose-dependent way, although its action did not result in elimination of the parasite and was only temp...

journal_title：Antimicrobial agents and chemotherapy

authors： Otten-Kuipers MA,Franssen FF,Nieuwenhuijs H,Overdulve JP,Roelofsen B,Op den Kamp JA

更新日期：1997-08-01 00:00:00

abstract：:In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chinh NT,Quang NN,Anh CX,Thanh NX,Dai B,Birrell GW,Chavchich M,Edstein MD

更新日期：2011-09-01 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00

abstract：:The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S_0636-A1S_0637, A1S_1174-A1S_1173, and A1S_1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that...

journal_title：Antimicrobial agents and chemotherapy

authors： Aranda J,López M,Leiva E,Magán A,Adler B,Bou G,Barbé J

更新日期：2014-01-01 00:00:00

abstract：:The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug efflux transporters. Raltegravir uptake, accumulation, and permeability were evaluated in vitro in (i) P-glycoprotein (P-gp), breast cancer resistance protein (BCRP...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoque MT,Kis O,De Rosa MF,Bendayan R

更新日期：2015-05-01 00:00:00

abstract：:Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Rank LA,Walsh NM,Liu R,Lim FY,Bok JW,Huang M,Keller NP,Gellman SH,Hull CM

更新日期：2017-09-22 00:00:00

abstract：:Twenty-one adult patients hospitalized with lower respiratory tract infections due to Branhamella catarrhalis or Haemophilus influenzae or both were treated with the combination of oral amoxicillin and potassium clavulanate (Augmentin) in an open, noncomparative clinical trial. Diseases included pneumonia, empyema, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Steele LC,Brooks DL,Luman JI,Wilson RW,McLarty JW

更新日期：1985-06-01 00:00:00