Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method.

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen with increasing prevalence, which is able to cause infections in immunocompromised patients or in those with a previous pathology. The treatment of the infections caused by this bacterium is often complicated due to the several intrinsic antibiotic resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco P,Corona F,Sánchez MB,Martínez JL

更新日期：2017-04-24 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:An association exists between respiratory viruses and bacterial infections. Prevention or treatment of the preceding viral infection is a logical goal for reducing this important cause of morbidity and mortality. The ability of the novel, selective parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alymova IV,Portner A,Takimoto T,Boyd KL,Babu YS,McCullers JA

更新日期：2005-01-01 00:00:00

abstract：:In most experiments when aminoglycoside antibiotic (AG) tissue levels are measured, the AG is extracted into buffered media. The data from this study reveal that buffer extraction results in only partial recovery of AG from tissues and that total recovery can be obtained after NaOH or trichloroacetic acid treatment. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Fox KE

更新日期：1989-04-01 00:00:00

abstract：:Sporadic isolates of carbapenem-resistant KPC-2-producing Klebsiella pneumoniae were isolated in Tel Aviv Medical Center during 2005 and 2006, parallel to the emergence of the KPC-3-producing K. pneumoniae sequence type 258 (ST 258). We aimed to study the molecular epidemiology of these isolates and to characterize th...

journal_title：Antimicrobial agents and chemotherapy

authors： Leavitt A,Carmeli Y,Chmelnitsky I,Goren MG,Ofek I,Navon-Venezia S

更新日期：2010-07-01 00:00:00

abstract：:We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine (AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in human renal proximal tubule epithelial cells (RPTECs). The cells were treated with various concentrations and combinations of the teste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidal F,Domingo JC,Guallar J,Saumoy M,Cordobilla B,Sánchez de la Rosa R,Giralt M,Alvarez ML,López-Dupla M,Torres F,Villarroya F,Cihlar T,Domingo P

更新日期：2006-11-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:Quinolones, in addition to their antibacterial activities, act as immunomodulators. Osteopontin (OPN), a member of the extracellular matrix proteins, was found to play a role in the immune and inflammatory response. We found that quinolones significantly enhanced OPN secretion, namely, garenoxacin (220%), moxifloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Shiratori B,Zhang J,Usami O,Chagan-Yasutan H,Suzuki Y,Nakajima C,Uede T,Hattori T

更新日期：2012-06-01 00:00:00

abstract：:TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TE...

journal_title：Antimicrobial agents and chemotherapy

authors： Siu LK,Ho PL,Yuen KY,Wong SS,Chau PY

更新日期：1997-02-01 00:00:00

abstract：:The pharmacodynamics of gemifloxacin against Streptococcus pneumoniae were investigated in a dilutional pharmacodynamic model of infection. Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every...

journal_title：Antimicrobial agents and chemotherapy

authors： MacGowan AP,Rogers CA,Holt HA,Wootton M,Bowker KE

更新日期：2001-10-01 00:00:00

abstract：:Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if K13 mutations affect a dormancy phenotype allowing parasites to survive DHA exposure and then sorbitol selection. Although recrudescence from dormancy diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Breglio KF,Rahman RS,Sá JM,Hott A,Roberts DJ,Wellems TE

更新日期：2018-04-26 00:00:00

abstract：:Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations....

journal_title：Antimicrobial agents and chemotherapy

authors： Sekaggya-Wiltshire C,Chirehwa M,Musaazi J,von Braun A,Buzibye A,Muller D,Gutteck U,Motta I,Calcagno A,Fehr JS,Kambugu A,Castelnuovo B,Lamorde M,Denti P

更新日期：2019-05-24 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:In a 1964 study of the pharmacokinetic determinants of penicillin cure of gonococcal urethritis, 45 male prisoner volunteers were experimentally infected with strains of Neisseria gonorrhoeae having known in vitro penicillin susceptibility. After developing urethritis, subjects received intramuscular penicillin G and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaffe HW,Schroeter AL,Reynolds GH,Zaidi AA,Martin JE Jr,Thayer JD

更新日期：1979-04-01 00:00:00

abstract：:Antibacterial agents disrupt the ecological balance of the normal human microflora. Tigecycline, a member of a new class of antibiotics (glycylcyclines), has been shown to have a potent broad-spectrum activity against most gram-positive and gram-negative aerobic and anaerobic bacteria. The aim of the study was to inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Nord CE,Sillerström E,Wahlund E

更新日期：2006-10-01 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:We tested the ability of antimicrobial agents that act on the cell wall to kill enterococci and found defective killing (a minimal bactericidal concentration/minimal inhibitory concentration ratio of greater than or equal to 32) with both beta-lactams (penicillin G and cephalothin) and non-beta-lactams (vancomycin, cy...

journal_title：Antimicrobial agents and chemotherapy

authors： Krogstad DJ,Pargwette AR

更新日期：1980-06-01 00:00:00

abstract：:The objective of this study was to determine the population pharmacokinetic parameters of levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at the University Hospital in Vitória, Brazil, participated. Subjects received multiple doses of one drug (levoflo...

journal_title：Antimicrobial agents and chemotherapy

authors： Peloquin CA,Hadad DJ,Molino LP,Palaci M,Boom WH,Dietze R,Johnson JL

更新日期：2008-03-01 00:00:00

abstract：:Antimicrobial lock solutions are important for prevention of microbial colonization and infection of long-term central venous catheters. We investigated the efficacy and safety of a novel antibiotic-free lock solution formed from gas plasma-activated disinfectant (PAD). Using a luminal biofilm model, viable cells of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhatt S,Mehta P,Chen C,Daines DA,Mermel LA,Chen HL,Kong MG

更新日期：2018-07-27 00:00:00

abstract：:The creation of new chemotherapeutic regimens that permit shortening the duration of treatment is a major priority for antituberculosis drug development. In this study, we used the murine model of experimental tuberculosis therapy to determine whether incorporation of the investigational new nitroimidazopyran PA-824 i...

journal_title：Antimicrobial agents and chemotherapy

authors： Nuermberger E,Rosenthal I,Tyagi S,Williams KN,Almeida D,Peloquin CA,Bishai WR,Grosset JH

更新日期：2006-08-01 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:Using a real-time PCR assay specific for a mosaic penA allele that has been associated with oral cephalosporin resistance in Asia, 54 available Neisseria gonorrhoeae isolates collected in San Francisco, CA, from January to October 2008 were analyzed. Five isolates tested positive for the mosaic penA gene by real-time ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pandori M,Barry PM,Wu A,Ren A,Whittington WL,Liska S,Klausner JD

更新日期：2009-09-01 00:00:00

abstract：:Amoxicillin was studied in normal subjects after intravenous, oral, and intramuscular administration of 250-, 500-, and 1,000-mg doses. Serum drug levels were analyzed using a two-compartment open model, as well as area under the curve (AUC) and urinary recovery. The variations of these pharmacokinetic parameters were...

journal_title：Antimicrobial agents and chemotherapy

authors： Spyker DA,Rugloski RJ,Vann RL,O'Brien WM

更新日期：1977-01-01 00:00:00

abstract：:Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercia...

journal_title：Antimicrobial agents and chemotherapy

authors： Bennett JE,Jennings AE

更新日期：1978-04-01 00:00:00

abstract：:The serum pharmacokinetic profile of intravenous (i.v.) tobramycin administration was characterized for a sample of nine adult patients with cystic fibrosis (CF) who were hospitalized for an acute pulmonary exacerbation. Current recommended i.v. tobramycin dosing protocols are predicted through modeling and simulation...

journal_title：Antimicrobial agents and chemotherapy

authors： Butterfield JM,Lodise TP,Beegle S,Rosen J,Farkas J,Pai MP

更新日期：2013-10-01 00:00:00

abstract：:Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Blandizzi C,Malizia T,Batoni G,Ghelardi E,Baschiera F,Bruschini P,Senesi S,Campa M,Del Tacca M

更新日期：2002-05-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hobbie SN,Pfister P,Brüll C,Westhof E,Böttger EC

更新日期：2005-12-01 00:00:00