Cefiderocol Resistance in Acinetobacter baumannii: Roles of β-Lactamases, Siderophore Receptors, and Penicillin Binding Protein 3.


:Cefiderocol is a siderophore cephalosporin active against many multidrug-resistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from ≤0.03 to >32 μg/ml. Cefiderocol resistance could not be explained by β-lactamase activity. Cefiderocol resistance was associated with reduced expression of the siderophore receptor gene pirA Mutations involving PBP3 may have contributed to resistance in one strain. Additional studies are needed to assess the role of other siderophore receptors.


Malik S,Kaminski M,Landman D,Quale J




Has Abstract


2020-10-20 00:00:00












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    abstract::The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

    更新日期:1998-11-01 00:00:00

  • 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.

    abstract::The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Van Rompay KK,Cherrington JM,Marthas ML,Berardi CJ,Mulato AS,Spinner A,Tarara RP,Canfield DR,Telm S,Bischofberger N,Pedersen NC

    更新日期:1996-11-01 00:00:00

  • Therapy of genital herpes with topically applied interferon.

    abstract::Ninety-four patients with recurrences of genital herpes were randomized in a double-blind trial to receive topical therapy for 5 days with either alpha-2a interferon at 30 X 10(6) IU/ml or 10 X 10(6) IU/ml or placebo six times daily. No differences were noted between either interferon dose and placebo with respect to ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eron LJ,Toy C,Salsitz B,Scheer RR,Wood DL,Nadler PI

    更新日期:1987-07-01 00:00:00

  • Proof-of-Principle Study in a Murine Lung Infection Model of Antipseudomonal Activity of Phage PEV20 in a Dry-Powder Formulation.

    abstract::Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been documented to be efficacious against multidrug-resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, p...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chang RYK,Chen K,Wang J,Wallin M,Britton W,Morales S,Kutter E,Li J,Chan HK

    更新日期:2018-01-25 00:00:00

  • A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.

    abstract::Recent years have seen the rapid advancement of new therapeutic agents against hepatitis C virus (HCV) in response to the need for treatment that is unmet by interferon (IFN)-based therapies. Most antiviral drugs discovered to date are small molecules that modulate viral enzyme activities. In the search for highly sel...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cheng Y,Tsou LK,Cai J,Aya T,Dutschman GE,Gullen EA,Grill SP,Chen AP,Lindenbach BD,Hamilton AD,Cheng YC

    更新日期:2010-01-01 00:00:00

  • Evidence of incorporation of the chromosomal beta-lactamase gene of Enterococcus faecalis CH19 into a transposon derived from staphylococci.

    abstract::We recently reported the chromosomal location of the staphylococcal beta-lactamase gene in four strains of Enterococcus faecalis. Transfer of this gene from strain CH19 to an enterococcal recipient was accompanied by transfer of numerous other antimicrobial resistance determinants in the absence of detectable plasmid ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rice LB,Marshall SH

    更新日期:1992-09-01 00:00:00

  • Antimicrobial activity of ceftaroline-avibactam tested against clinical isolates collected from U.S. Medical Centers in 2010-2011.

    abstract::Ceftaroline-avibactam and comparator agents were tested by the broth microdilution method against 20,089 isolates consecutively collected in 2010 and 2011 from 75 U.S. medical centers. Ceftaroline-avibactam was active against Enterobacteriaceae (4,908 strains; MIC90, 0.25 μg/ml; highest MIC, 4 μg/ml), including merope...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sader HS,Flamm RK,Jones RN

    更新日期:2013-04-01 00:00:00

  • Role of extracellular iron in the action of the quinone antibiotic streptonigrin: mechanisms of killing and resistance of Neisseria gonorrhoeae.

    abstract::The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococca...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    更新日期:1987-10-01 00:00:00

  • Biochemical characterization of the metallo-beta-lactamase CcrA from Bacteroides fragilis TAL3636.

    abstract::The CcrA beta-lactamase from Bacteroides fragilis TAL3636 was cloned into Escherichia coli and purified from inclusion bodies. This group 3 metalloenzyme hydrolyzed most beta-lactam antibiotics, including cephamycins and carbapenems. Following inhibition by chelators, enzyme activity was recovered with the cations Zn2...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    更新日期:1992-05-01 00:00:00

  • Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Ginsberg AM,Laurenzi MW,Rouse DJ,Whitney KD,Spigelman MK

    更新日期:2009-09-01 00:00:00

  • Many class I integrons comprise distinct stable structures occurring in different species of Enterobacteriaceae isolated from widespread geographic regions in Europe.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1981-01-01 00:00:00

  • Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis.

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    pub_type: 杂志文章


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    更新日期:2007-12-01 00:00:00

  • Hemodialysis clearance of metronidazole and its metabolites.

    abstract::Metronidazole is now being used with increasing frequency for various infectious conditions in patients with renal failure. It is commonly administered to septic patients who have developed acute renal failure requiring hemodialysis. The hemodialysis clearances of metronidazole and its metabolites were evaluated in ni...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lau AH,Chang CW,Sabatini S

    更新日期:1986-02-01 00:00:00

  • Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.

    abstract::The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tylewska S,Hjertén S,Wadström T

    更新日期:1981-11-01 00:00:00

  • Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases.

    abstract::Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

    更新日期:2016-03-25 00:00:00

  • A Hypothesis-Generating Study of the Combination of Aspirin plus Macrolides in Patients with Severe Community-Acquired Pneumonia.

    abstract::While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infection, excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP) who were treated with macrolides and aspirin would receive benefit beyond that of c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Falcone M,Russo A,Shindo Y,Farcomeni A,Pieralli F,Cangemi R,Liu J,Xia J,Okumura J,Sano M,Jones C,Vannucchi V,Mancone M,Micek S,Xu F,Violi F,Kollef M

    更新日期:2019-01-29 00:00:00

  • In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads.

    abstract::Antibiotic-impregnated beads are used in the dead bone space following debridement surgery to deliver local, high concentrations of antibiotics. Polymethylmethacrylate (PMMA), 2,000-molecular-weight (MW) polylactic acid (PLA), Poly(DL-lactide)-coglycolide (PL:CG; 90:10, 80:20, and 70:30), and the combination 2,000-MW ...

    journal_title:Antimicrobial agents and chemotherapy

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  • Inhibition of Rift Valley fever virus replication and perturbation of nucleocapsid-RNA interactions by suramin.

    abstract::Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ellenbecker M,Lanchy JM,Lodmell JS

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  • In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-Resistant Enterobacteriaceae.

    abstract::LYS228 is a novel monobactam with potent activity against Enterobacteriaceae LYS228 is stable to metallo-β-lactamases (MBLs) and serine carbapenemases, including Klebsiella pneumoniae carbapenemases (KPCs), resulting in potency against the majority of extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resis...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Blais J,Lopez S,Li C,Ruzin A,Ranjitkar S,Dean CR,Leeds JA,Casarez A,Simmons RL,Reck F

    更新日期:2018-09-24 00:00:00

  • Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.

    abstract::Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercia...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bennett JE,Jennings AE

    更新日期:1978-04-01 00:00:00

  • Efficacy of ceftaroline fosamil against penicillin-sensitive and -resistant streptococcus pneumoniae in an experimental rabbit meningitis model.

    abstract::Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cottagnoud P,Cottagnoud M,Acosta F,Stucki A

    更新日期:2013-10-01 00:00:00

  • parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Galbraith KM,Ng AC,Eggers BJ,Kuchel CR,Eggers CH,Samuels DS

    更新日期:2005-10-01 00:00:00

  • Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.

    abstract::Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives were compared with cognate fluoroquinolones by using cultured Mycobacterium smegmatis. Diones exhibited higher MIC values than fluoroquinol...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Malik M,Marks KR,Mustaev A,Zhao X,Chavda K,Kerns RJ,Drlica K

    更新日期:2011-05-01 00:00:00

  • Burkholderia is highly resistant to human Beta-defensin 3.

    abstract::The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC],

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sahly H,Schubert S,Harder J,Rautenberg P,Ullmann U,Schröder J,Podschun R

    更新日期:2003-05-01 00:00:00

  • Microbiological aetiology, epidemiology, and clinical profile of prosthetic joint infections: are current antibiotic prophylaxis guidelines effective?

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Peel TN,Cheng AC,Buising KL,Choong PF

    更新日期:2012-05-01 00:00:00

  • Comparison of the binding of penicillin G to staphylococcal L-form and its parent strain membranes.

    abstract::The binding of penicillin G to a stable L-form from Staphylococcus aureus followed saturation-type kinetics with saturation achieved at 0.75 nmol/ml, the same as with its parent strain. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Suginaka H

    更新日期:1976-03-01 00:00:00

  • Mechanism of action of quinolones against Escherichia coli DNA gyrase.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

    更新日期:1993-04-01 00:00:00

  • Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.

    abstract::Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Coelho AC,Messier N,Ouellette M,Cotrim PC

    更新日期:2007-08-01 00:00:00