High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr.

abstract：:Although antimicrobial agents are effective therapy for early Lyme disease, optimal treatment schedules have not been conclusively established. The efficacy of various dosages of eight antibiotics used for borreliosis treatment was evaluated for C3H/HeNCrIBR mice, which reproducibly develop persistent infection, arthr...

journal_title：Antimicrobial agents and chemotherapy

authors： Moody KD,Adams RL,Barthold SW

更新日期：1994-07-01 00:00:00

abstract：:Among yeast strains of human origin belonging to the genera Candida, Cryptococcus, Torulopsis, and Rhodotorula which were examined for killer and sensitive characteristics with killer and sensitive strains of Cryptococcus, Hansenula, Kluyveromyces, Pichia, Saccharomyces, and Torulopsis as screening organisms, a high i...

journal_title：Antimicrobial agents and chemotherapy

authors： Middelbeek EJ,Hermans JM,Stumm C,Muytjens HL

更新日期：1980-03-01 00:00:00

abstract：:Since currently available therapies against HIV/AIDS still show important drawbacks, the development of novel anti-HIV treatments is a key issue. We recently characterized methylated oligoribonucleotides (mONs) that extensively inhibit HIV-1 replication in primary T cells at nanomolar concentrations. The mONs were sho...

journal_title：Antimicrobial agents and chemotherapy

authors： Avilov SV,Boudier C,Gottikh M,Darlix JL,Mély Y

更新日期：2012-02-01 00:00:00

abstract：:The NS3/4A protease from hepatitis C virus (HCV) plays a key role in viral replication. We report a system for monitoring the activity of this enzyme in single living mammalian cells. We constructed a fluorescence resonance energy transfer (FRET) probe that consists of an enhanced cyan fluorescent protein-citrine fusi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabariegos R,Picazo F,Domingo B,Franco S,Martinez MA,Llopis J

更新日期：2009-02-01 00:00:00

abstract：:Seventy-two (54.5%) out of 132 fecal samples from a group of yellow-legged gulls in Barcelona, Spain, were positive for Escherichia coli producing either extended-spectrum β-lactamases (ESBL) (51.5%), carbapenemase (1.5%), or cephamycinase (1.5%). The isolation of two carbapenemase-producing E. coli strains is a matte...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Pitart C,Montalvo T,Roca I,Sabaté S,Hurtado JC,Planell R,Marco F,Ramírez B,Peracho V,de Simón M,Vila J

更新日期：2017-01-24 00:00:00

abstract：:CP-65,207 is a new parenteral penem antibiotic with a broad spectrum that includes gram-positive, gram-negative, and anaerobic microorganisms, with MICs for 90% (MIC90s) of the majority of 1,101 clinical pathogens tested being less than or equal to 1 microgram/ml. The compound was from 10- to 100-fold more active than...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz T,Retsema J,Girard A,Hamanaka E,Anderson M,Sokolowski S

更新日期：1989-08-01 00:00:00

abstract：:Occidiofungin is produced by the soil bacterium Burkolderia contaminans MS14 and is structurally similar or identical to the burkholdines, xylocandins, and cepacidines. This study identified the primary cellular target of occidiofungin, which was determined to be actin. The modification of occidiofungin with a functio...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravichandran A,Geng M,Hull KG,Li J,Romo D,Lu SE,Albee A,Nutter C,Gordon DM,Ghannoum MA,Lockless SW,Smith L

更新日期：2018-12-21 00:00:00

abstract：:The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A ag...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita K,Kawabe H,Mitsuhashi S

更新日期：1981-07-01 00:00:00

abstract：:Plasmid-mediated resistance to polymyxins mediated by the MCR-1/2 determinants has been reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella spp. were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Kieffer N,Nordmann P,Poirel L

更新日期：2017-05-24 00:00:00

abstract：:A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of...

journal_title：Antimicrobial agents and chemotherapy

authors： Espuelas S,Legrand P,Loiseau PM,Bories C,Barratt G,Irache JM

更新日期：2000-08-01 00:00:00

abstract：:Rabbits with nutritionally variant viridans group streptococcal experimental endocarditis were treated three times daily for 3 days with procaine penicillin (1.2 X 10(6) U) alone or together with low-dose streptomycin (2 mg/kg), high-dose streptomycin (8 mg/kg), low-dose gentamicin (0.32 mg/kg), or high-dose gentamici...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry NK,Wilson WR,Roberts RB,Acar JF,Geraci JE

更新日期：1986-09-01 00:00:00

abstract：:Mycobacteria grew rapidly in FST medium (tissue culture medium F12 supplemented with 5% serum and 0.05% Tween 80). Growth of Mycobacterium tuberculosis and other niacin-negative mycobacteria in flat-bottomed, 96-well tissue culture plates was estimable by the naked eye within 3 to 5 days when mycobacteria were inocula...

journal_title：Antimicrobial agents and chemotherapy

authors： Nozawa RT,Yokota T

更新日期：1983-08-01 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from t...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith MJ,Gonzalez D,Goldman JL,Yogev R,Sullivan JE,Reed MD,Anand R,Martz K,Berezny K,Benjamin DK Jr,Smith PB,Cohen-Wolkowiez M,Watt K,Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

更新日期：2017-03-24 00:00:00

abstract：:We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necro...

journal_title：Antimicrobial agents and chemotherapy

authors： Su F,Xue Y,Wang Y,Zhang L,Chen W,Hu S

更新日期：2015-09-01 00:00:00

abstract：:The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman D,Bryskier A,Lowther J,Appelbaum PC

更新日期：2006-11-01 00:00:00

abstract：:TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In Escherichia coli cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Starosta AL,Fyfe C,O'Brien W,Rothstein DM,Mikolajka A,Wilson DN,Sutcliffe JA

更新日期：2012-05-01 00:00:00

abstract：:The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

journal_title：Antimicrobial agents and chemotherapy

authors： Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

更新日期：1996-08-01 00:00:00

abstract：:Sixteen weeks of treatment with clarithromycin (CLARI) alone displayed significant bactericidal activity against Mycobacterium avium complex infection in beige mice. Only two combined regimens, CLARI combined with an initial 4 or 8 weeks of amikacin (AMIKA), displayed activity greater than that displayed by CLARI alon...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Ji B,Truffot-Pernot C,Grosset J

更新日期：1995-03-01 00:00:00

abstract：:The pharmacokinetics of meropenem and its ring-opened metabolite (ICI 213,689) were investigated with eight young (20- to 34-year-old) and eight elderly (67- to 80-year-old) healthy male volunteers given single 30-min intravenous infusions of 500 mg of meropenem. All subjects had normal age-correlated glomerular funct...

journal_title：Antimicrobial agents and chemotherapy

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1992-07-01 00:00:00

abstract：:Recent pharmacokinetic studies that included children found that serum drug levels were low compared to those of adults for whom the same dosages were used. This study aimed to characterize the pharmacokinetics of pyrazinamide and ethambutol in Malawian children and to examine the impact of age, nutritional status, an...

journal_title：Antimicrobial agents and chemotherapy

authors： Graham SM,Bell DJ,Nyirongo S,Hartkoorn R,Ward SA,Molyneux EM

更新日期：2006-02-01 00:00:00

abstract：:The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Esc...

journal_title：Antimicrobial agents and chemotherapy

authors： Iizaka Y,Higashi N,Ishida M,Oiwa R,Ichikawa Y,Takeda M,Anzai Y,Kato F

更新日期：2013-03-01 00:00:00

abstract：:The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate in the parenteral treatment of systemic herpes simplex virus type 1 infections in Swiss mice were determined. Among cont...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Westbrook L,Arnett G,Daluge S,Lee H,Vince R

更新日期：1983-10-01 00:00:00

abstract：:Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Khlif M,Bogreau H,Michel-Nguyen A,Ayadi A,Ranque S

更新日期：2010-03-01 00:00:00

abstract：:A novel gene encoding an aminoglycoside 3-N-acetyltransferase, which confers resistance to gentamicin, astromicin, and sisomicin, was cloned from Pseudomonas aeruginosa Stone 130. Its sequence was determined and found to show considerable similarity to an aac(3)-I gene previously cloned from R plasmids from Enterobact...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwocho LR,Schaffner CP,Miller GH,Hare RS,Shaw KJ

更新日期：1995-08-01 00:00:00

abstract：:Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

journal_title：Antimicrobial agents and chemotherapy

authors： Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

更新日期：1985-02-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of rifampin on efavirenz pharmacokinetics. Subjects were randomized to re...

journal_title：Antimicrobial agents and chemotherapy

authors： Kwara A,Tashima KT,Dumond JB,Poethke P,Kurpewski J,Kashuba AD,Court MH,Greenblatt DJ

更新日期：2011-07-01 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma bruceirhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an e...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiedemar N,Hauser DA,Mäser P

更新日期：2020-02-21 00:00:00