Treatment of Pseudomonas aeruginosa-infected orthopedic prostheses with ceftazidime-ciprofloxacin antibiotic combination.

abstract：:Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protei...

journal_title：Antimicrobial agents and chemotherapy

authors： Honoré N,Cole ST

更新日期：1994-02-01 00:00:00

abstract：:The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from ext...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranjan A,Shaik S,Mondal A,Nandanwar N,Hussain A,Semmler T,Kumar N,Tiwari SK,Jadhav S,Wieler LH,Ahmed N

更新日期：2016-10-21 00:00:00

abstract：:The anti-pseudomonas activities of azlocillin and mezlocillin were compared with that of ticarcillin. We measured the minimal inhibitory and minimal bactericidal concentrations of the three drugs against 20 different strains of Pseudomonas aeruginosa and found significantly lower values for azlocillin than for the oth...

journal_title：Antimicrobial agents and chemotherapy

authors： Coppens L,Klastersky J

更新日期：1979-03-01 00:00:00

abstract：:Since transmission of Chagas' disease by the insect vector is under control in Brazil, transmission by blood transfusion is acquiring special relevance in areas where the disease is endemic and also in countries whose populations are free of infection but that are receiving immigrants from areas where the disease is e...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiari E,Oliveira AB,Prado MA,Alves RJ,Galvão LM,Araujo FG

更新日期：1996-03-01 00:00:00

abstract：:A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Simon GL,Snydman DR,Tally FP,Gorbach SL

更新日期：1980-07-01 00:00:00

abstract：:Rifabutin pharmacokinetics were studied by the population approach (NONMEM) with 40 human immunodeficiency virus-infected patients receiving rifabutin at different doses for prophylaxis or therapy of mycobacterial infections. A two-compartment open model with first-order absorption was used as the structural pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Papa P,Torre D,Andreoni M,Poggio A,Bassetti M,Marone P

更新日期：1998-08-01 00:00:00

abstract：:Adult diabetic patients admitted to our Diabetes Center from September 1996 to January 1998 for severe, limb-threatening foot infection were consecutively enrolled in a prospective, randomized, controlled clinical study aimed at assessing the safety and efficacy of recombinant human granulocyte colony-stimulating fact...

journal_title：Antimicrobial agents and chemotherapy

authors： de Lalla F,Pellizzer G,Strazzabosco M,Martini Z,Du Jardin G,Lora L,Fabris P,Benedetti P,Erle G

更新日期：2001-04-01 00:00:00

abstract：:The effect of 19 antimicrobial agents on human polymorphonuclear leukocyte function was evaluated by chemiluminescence assays, yeast phagocytosis and killing, and lactate dehydrogenase release. Tetracycline and trimethoprim inhibited chemiluminescence and reduced killing at therapeutic concentrations of 2 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Welch WD,Davis D,Thrupp LD

更新日期：1981-07-01 00:00:00

abstract：:We have cloned a 4.9-kilobase (kb) HincII fragment which contains a tetracycline resistance determinant (tetM) from the chromosome of Ureaplasma urealyticum. The 4.9-kb HincII fragment contains DNA in addition to the structural gene, is closely related to the previously characterized 5.0-kb fragment from pJI3, and con...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown JT,Roberts MC

更新日期：1987-11-01 00:00:00

abstract：:The activity of cefotaxime, either alone or combined with an aminoglycoside, was determined against 50 isolates of Pseudomonas aeruginosa, of which 50, 33, and 10 were resistant to gentamicin, tobramycin, and amikacin, respectively. Cefotaxime inhibited 34 isolates at a concentration of 16 microgram/ml and all isolate...

journal_title：Antimicrobial agents and chemotherapy

authors： Murray PR

更新日期：1980-03-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) can be mechanistically classified into carbapenemase-producing Enterobacteriaceae (CPE) and non-carbapenemase-producing carbapenem nonsusceptible Enterobacteriaceae (NCPCRE). We sought to investigate the effect of antecedent carbapenem exposure as a risk factor for NCPCRE ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marimuthu K,Ng OT,Cherng BPZ,Fong RKC,Pada SK,De PP,Ooi ST,Smitasin N,Thoon KC,Krishnan PU,Ang MLT,Chan DSG,Kwa ALH,Deepak RN,Chan YK,Chan YFZ,Huan X,Zaw Linn K,Tee NWS,Tan TY,Koh TH,Lin RTP,Hsu LY,Sengupta

更新日期：2019-09-23 00:00:00

abstract：:Ceftobiprole (formerly BAL9141), the active component of the prodrug BAL5788 (ceftobiprole medocaril), is a novel cephalosporin with expanded activity against gram-positive bacteria. Among 152 Staphylococcus aureus isolates, including 5 vancomycin-intermediate and 2 vancomycin-resistant strains, MIC(50) and MIC(90) va...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogdanovich T,Ednie LM,Shapiro S,Appelbaum PC

更新日期：2005-10-01 00:00:00

abstract：:We investigated the relationship between susceptibility to beta-lactam antibiotics and variation in the major outer membrane protein P2 (OmpP2; also called porin) of persistent nonencapsulated Haemophilus influenzae isolated from cystic fibrosis patients. Nine OmpP2 variants were selected from two distinct H. influenz...

journal_title：Antimicrobial agents and chemotherapy

authors： Regelink AG,Dahan D,Möller LV,Coulton JW,Eijk P,Van Ulsen P,Dankert J,Van Alphen L

更新日期：1999-02-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report the whole-genome sequence of this clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) was identified in...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou H,Zhang T,Yu D,Pi B,Yang Q,Zhou J,Hu S,Yu Y

更新日期：2011-10-01 00:00:00

abstract：:There are no data comparing outcomes of patients treated with ceftazidime-avibactam versus comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P ...

journal_title：Antimicrobial agents and chemotherapy

authors： Shields RK,Nguyen MH,Chen L,Press EG,Potoski BA,Marini RV,Doi Y,Kreiswirth BN,Clancy CJ

更新日期：2017-07-25 00:00:00

abstract：:Nosocomial pneumonia and sepsis, as well as severe diffuse peritonitis, must be treated early in order to prevent complications such as septic shock and organ dysfunctions. With the availability of new broad-spectrum and highly bactericidal antibiotics, the need of combining beta-lactams with aminoglycosides for the t...

journal_title：Antimicrobial agents and chemotherapy

authors： Cometta A,Baumgartner JD,Lew D,Zimmerli W,Pittet D,Chopart P,Schaad U,Herter C,Eggimann P,Huber O

更新日期：1994-06-01 00:00:00

abstract：:The binding of the outer membrane-disorganizing peptide polymyxin B nonapeptide (PMBN) to gram-negative bacteria was studied by using tritium-labeled PMBN. Smooth Salmonella typhimurium had a binding capacity of ca. 6 nmol of PMBN per mg (dry weight) of bacteria, which corresponds to ca. 1 X 10(6) to 2 X 10(6) molecul...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Viljanen P

更新日期：1985-04-01 00:00:00

abstract：:The outer membrane permeability to meropenem and imipenem in Escherichia coli K-12 was investigated, and its porin-deficient mutants were transformed with a constructed vector carrying the carbapenem-hydrolyzing CphA metallo-beta-lactamase gene. By using the method of Zimmermann and Rosselet, meropenem was shown to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Cornaglia G,Guan L,Fontana R,Satta G

更新日期：1992-09-01 00:00:00

abstract：:Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (...

journal_title：Antimicrobial agents and chemotherapy

authors： Calcagno A,Dal Conte I,Cattaneo D,Testi R,Mistrangelo M,Gervasoni C,de Nicolò A,Bonora S,D'Avolio A,Di Perri G

更新日期：2020-10-26 00:00:00

abstract：:Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients an...

journal_title：Antimicrobial agents and chemotherapy

authors： Deng F,Shen J,Zhang M,Wu C,Zhang Q,Wang Y

更新日期：2015-10-01 00:00:00

abstract：:The aim of this open-label, fixed-sequence study was to investigate the potential of the botanical supplement Echinacea purpurea to interact with etravirine, a nonnucleoside reverse transcriptase inhibitor of HIV. Fifteen HIV-infected patients receiving antiretroviral therapy with etravirine (400 mg once daily) for at...

journal_title：Antimicrobial agents and chemotherapy

authors： Moltó J,Valle M,Miranda C,Cedeño S,Negredo E,Clotet B

更新日期：2012-10-01 00:00:00

abstract：:Biofilm production is an important step in the pathogenesis of Staphylococcus epidermidis polymer-associated infections and depends on the expression of the icaADBC operon leading to the synthesis of a polysaccharide intercellular adhesin. A chromosomally encoded reporter gene fusion between the ica promoter and the b...

journal_title：Antimicrobial agents and chemotherapy

authors： Rachid S,Ohlsen K,Witte W,Hacker J,Ziebuhr W

更新日期：2000-12-01 00:00:00

abstract：:Antibiotic treatment of lung infections may lead to the emergence of resistance in the gut flora. Appropriate dosing regimens could mitigate this adverse effect. In gnotobiotic rats harboring intestinal Escherichia coli and Enterococcus faecium populations, a lung infection by Klebsiella pneumoniae was instigated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2010-07-01 00:00:00

abstract：:Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang G,Kamalakaran S,Dhand A,Huang W,Ojaimi C,Zhuge J,Yee LL,Mayigowda P,Surendraiah PK,Dimitrova N,Fallon JT

更新日期：2014-08-01 00:00:00

abstract：:The bioactivity of imipenem at 20 micrograms/ml in various agar and broth media which are commonly used in susceptibility test assays was measured at different storage temperatures over time. Imipenem was found to be more stable at 4 degrees C than at -20 degrees C and least stable in all media at 35 degrees C. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Baron EJ,Hindler JA

更新日期：1984-06-01 00:00:00

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:Iron-sulfur flavoproteins (Isf) are flavin mononucleotide (FMN)- and FeS cluster-containing proteins commonly encountered in anaerobic prokaryotes. However, with the exception of Isf from Methanosarcina thermophila, which participates in oxidative stress management by removing oxygen and hydrogen peroxide, none of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Smutná T,Pilarová K,Tarábek J,Tachezy J,Hrdý I

更新日期：2014-06-01 00:00:00

abstract：:This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sethi S,Breton J,Wynne B

更新日期：2005-01-01 00:00:00