Effect of metronidazole resistance on bacterial eradication of Helicobacter pylori in infected children.


:A prospective study was performed with 23 Helicobacter pylori-infected children (mean age, 9.5 +/- 4.4 years) with clinical symptoms of gastritis and positive results of culture and histologic examination of gastric biopsy specimens to evaluate the influence of antibiotic resistance on eradication. Positive children were treated for 4 weeks with lansoprazole and for 2 weeks with either amoxicillin-metronidazole or spiramycin (a macrolide)-metronidazole. At endoscopy 1 month after the discontinuation of therapy, the eradication rate and improvement of histologically related gastritis were significantly dependent on the susceptibility or the resistance of the infecting organism to metronidazole (83 versus 17% and 88 versus 16.6%, respectively). Pretreatment determination of the susceptibility is appropriate in any anti-H, pylori regimen, including one with metronidazole.


Raymond J,Kalach N,Bergeret M,Benhamou PH,Barbet JP,Gendrel D,Dupont C




Has Abstract


1998-06-01 00:00:00












  • Metabolic drug-drug interaction potential of macrolactin A and 7-O-succinyl macrolactin A assessed by evaluating cytochrome P450 inhibition and induction and UDP-glucuronosyltransferase inhibition in vitro.

    abstract::Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

    更新日期:2014-09-01 00:00:00

  • In vitro and in vivo interactions between miltefosine and other antileishmanial drugs.

    abstract::The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Seifert K,Croft SL

    更新日期:2006-01-01 00:00:00

  • Activities of Nigerian chewing stick extracts against Bacteroides gingivalis and Bacteroides melaninogenicus.

    abstract::The in vitro activities of extracts of Nigerian chewing sticks against Bacteroides gingivalis and B. melaninogenicus are presented. The greatest inhibitory action was produced by Serindeia werneckei, whereas Fagara zanthoxyloides produced no appreciable inhibitory effect. A generally good correlation was found between...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rotimi VO,Laughon BE,Bartlett JG,Mosadomi HA

    更新日期:1988-04-01 00:00:00

  • Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.

    abstract::A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kadlec K,Schwarz S

    更新日期:2010-02-01 00:00:00

  • Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.

    abstract::The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-amin...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Poirel L,Aires-de-Sousa M,Kudyba P,Kieffer N,Nordmann P

    更新日期:2018-08-27 00:00:00

  • Induction of the Citrobacter freundii group I beta-lactamase in Escherichia coli is not dependent on entry of beta-lactam into the cytoplasm.

    abstract::Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Everett MJ,Chopra I,Bennett PM

    更新日期:1990-12-01 00:00:00

  • Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator.

    abstract::Burkholderia cepacia is recognized as an important pathogen in the lung infections of patients with cystic fibrosis. An inducible beta-lactamase activity has been associated with increased resistance to beta-lactam antibiotics in clinical isolates of B. cepacia. In this study, we report the revised sequence of the pen...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Trépanier S,Prince A,Huletsky A

    更新日期:1997-11-01 00:00:00

  • Factors governing the emergence of resistance to nalidixic acid in treatment of urinary tract infection.

    abstract::Cultures of Escherichia coli were exposed to nalidixic acid in an in vitro model in which the conditions of drug-organism interaction resembled those of bacterial cystitis treatment. Results obtained in this way suggested that emergence of bacterial resistance should not be a major problem in treatment of uncomplicate...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Greenwood D,O'Grady F

    更新日期:1977-12-01 00:00:00

  • Serum bactericidal activity of ceftazidime: continuous infusion versus intermittent injections.

    abstract::Since beta-lactam antibiotics have concentration-independent killing, bacterial eradication is a function of the time the serum drug concentration remains above the drug's MIC (T > MIC). We compared the serum bactericidal titers (SBTs) of ceftazidime given by continuous infusion (CI) or by intermittent bolus dosing (B...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nicolau DP,Nightingale CH,Banevicius MA,Fu Q,Quintiliani R

    更新日期:1996-01-01 00:00:00

  • Contributions of yap1 Mutation and Subsequent atrF Upregulation to Voriconazole Resistance in Aspergillus flavus.

    abstract::Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure of A. flavus to subinhibitory concentrations of VRC in vitro cau...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ukai Y,Kuroiwa M,Kurihara N,Naruse H,Homma T,Maki H,Naito A

    更新日期:2018-10-24 00:00:00

  • OXA-253, a variant of the carbapenem-hydrolyzing class D β-lactamase OXA-143 in Acinetobacter baumannii.

    abstract::The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Girlich D,Damaceno QS,Oliveira AC,Nordmann P

    更新日期:2014-05-01 00:00:00

  • Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.

    abstract::A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Alonso A,Sanchez P,Martínez JL

    更新日期:2000-07-01 00:00:00

  • Cefoxitin inactivation by Bacteroides fragilis.

    abstract::We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

    更新日期:1983-12-01 00:00:00

  • Direct-current bactericidal effect on intact skin.

    abstract::Positive carbon-containing electrodes conveying 5 or more microA of constant direct current per cm2 showed bactericidal activity on intact back skin of 13 human subjects. This effect increased with the duration of stimulation up to a total surface bacterial kill at 20 h. When total current and current density were var...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bolton L,Foleno B,Means B,Petrucelli S

    更新日期:1980-07-01 00:00:00

  • Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada.

    abstract::A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

    更新日期:2020-04-21 00:00:00

  • Double-stranded ribonucleic acid from Mengo virus: production, characterization, and interferon-inducing and antiviral activities in comparison with polyriboinosinic-polyribocytidylic acid.

    abstract::Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

    更新日期:1973-05-01 00:00:00

  • In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases.

    abstract::We have determined the antifungal susceptibilities of 34 clinical isolates of the dimorphic fungus Sporothrix schenckii to 11 drugs using a microdilution method. In general, the type of growth phase (mycelial or yeast) and the temperature of incubation (30 or 35 degrees C) exerted a significant influence on the MICs. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Trilles L,Fernández-Torres B,Dos Santos Lazéra M,Wanke B,de Oliveira Schubach A,de Almeida Paes R,Inza I,Guarro J

    更新日期:2005-09-01 00:00:00

  • Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.

    abstract::Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show here that the m...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Arita-Morioka K,Yamanaka K,Mizunoe Y,Ogura T,Sugimoto S

    更新日期:2015-01-01 00:00:00

  • Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus.

    abstract::Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bryson D,Hettle AG,Boraston AB,Hobbs JK

    更新日期:2020-02-21 00:00:00

  • Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus.

    abstract::Invasive pulmonary aspergillosis (IPA) continues to rise in concert with increasing numbers of immune suppression techniques to treat other medical conditions and transplantation. Despite these advances, morbidity and mortality rates remain unacceptably high. One strategy used to optimize outcomes is antifungal pharma...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lepak AJ,Marchillo K,Vanhecker J,Andes DR

    更新日期:2013-12-01 00:00:00

  • Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

    abstract::Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Joseph P,Abdo MR,Boigegrain RA,Montero JL,Winum JY,Köhler S

    更新日期:2007-10-01 00:00:00

  • In vitro activity of trovafloxacin against Chlamydia pneumoniae.

    abstract::The in vitro susceptibilities of 12 strains of Chlamydia pneumoniae to a new quinolone, trovafloxacin, and ofloxacin, doxycycline, erythromycin, and azithromycin were determined. The activity of trovafloxacin was similar to that of ofloxacin, with a MIC at which 90% of the isolates are inhibited and a minimal concentr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Roblin PM,Kutlin A,Hammerschlag MR

    更新日期:1997-09-01 00:00:00

  • Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.

    abstract::The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tylewska S,Hjertén S,Wadström T

    更新日期:1981-11-01 00:00:00

  • In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line.

    abstract::Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy. Trop...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: McCabe RE,Yu GS,Conteas C,Morrill PR,McMorrow B

    更新日期:1991-01-01 00:00:00

  • Development of a Multiplex Real-Time PCR Assay for Rapid Detection of Tigecycline Resistance Gene tet(X) Variants from Bacterial, Fecal, and Environmental Samples.

    abstract::We developed a multiplex real-time SYBR green-based PCR assay for rapid detection of tet(X) and its variants, including tet(X1) and tet(X2) and high-level tigecycline resistance genes tet(X3), tet(X4), and tet(X5). We showed that the real-time PCR assay developed had high linearity (R2 ≥ 0.996), sensitivity (low detec...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fu Y,Liu D,Song H,Liu Z,Jiang H,Wang Y

    更新日期:2020-03-24 00:00:00

  • Clinical isolates of Aspergillus species remain fully susceptible to voriconazole in the post-voriconazole era.

    abstract::We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Guinea J,Recio S,Peláez T,Torres-Narbona M,Bouza E

    更新日期:2008-09-01 00:00:00

  • Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins.

    abstract::Although the use of probiotics based on Bacillus strains to fight off intestinal pathogens and antibiotic-associated diarrhea is widespread, the mechanisms involved in producing their beneficial effects remain unclear. Here, we studied the ability of compounds secreted by the probiotic Bacillus clausii strain O/C to c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ripert G,Racedo SM,Elie AM,Jacquot C,Bressollier P,Urdaci MC

    更新日期:2016-05-23 00:00:00

  • Severe Renal Impairment Has Minimal Impact on Doravirine Pharmacokinetics.

    abstract::Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

    更新日期:2018-07-27 00:00:00

  • WCK 5222 (Cefepime-Zidebactam) Antimicrobial Activity against Clinical Isolates of Gram-Negative Bacteria Collected Worldwide in 2015.

    abstract::WCK 5222 consists of cefepime combined with zidebactam, a bicyclo-acyl hydrazide β-lactam enhancer antibiotic with a dual action involving binding to Gram-negative bacterial PBP2 and β-lactamase inhibition. We evaluated the in vitro activity of cefepime-zidebactam against 7,876 contemporary (2015) clinical isolates of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sader HS,Castanheira M,Huband M,Jones RN,Flamm RK

    更新日期:2017-04-24 00:00:00

  • Aptamers that preferentially bind type IVB pili and inhibit human monocytic-cell invasion by Salmonella enterica serovar typhi.

    abstract::Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. enterica serovar Typhi pil operon located in Salmonella pathogenicity island 7, are important in the pathogenic process. In this study, by using...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pan Q,Zhang XL,Wu HY,He PW,Wang F,Zhang MS,Hu JM,Xia B,Wu J

    更新日期:2005-10-01 00:00:00