Comparison of the beta-lactamase gene cluster in clonally distinct strains of Enterococcus faecalis.

abstract：:A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clar...

journal_title：Antimicrobial agents and chemotherapy

authors： Debets-Ossenkopp YJ,Brinkman AB,Kuipers EJ,Vandenbroucke-Grauls CM,Kusters JG

更新日期：1998-10-01 00:00:00

abstract：:Arguably, one of the most common and consequential laboratory tests performed in the world is Mycobacterium tuberculosis susceptibility testing. M. tuberculosis resistance is defined by growth of > or =1% of a bacillary inoculum on the critical concentration of an antibiotic. The critical concentration was chosen base...

journal_title：Antimicrobial agents and chemotherapy

authors： Gumbo T

更新日期：2010-04-01 00:00:00

abstract：:The two groups of chromosomal beta-lactamases from Klebsiella oxytoca (OXY-1 and OXY-2) can be overproduced 73- to 223-fold, due to point mutations in the consensus sequences of their promoters. The different versions of promoters from blaOXY-1 and blaOXY-2 were cloned upstream of the chloramphenicol acetyltransferase...

journal_title：Antimicrobial agents and chemotherapy

authors： Fournier B,Gravel A,Hooper DC,Roy PH

更新日期：1999-04-01 00:00:00

abstract：:Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial urinary tract infections (UTIs) and pose significant clinical challenges. These infections are polymicrobial in nature and are often associated with multidrug-resistant pathogens, including uropathogenic Escherichia coli (UPEC)...

journal_title：Antimicrobial agents and chemotherapy

authors： Guiton PS,Cusumano CK,Kline KA,Dodson KW,Han Z,Janetka JW,Henderson JP,Caparon MG,Hultgren SJ

更新日期：2012-09-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) involves combination treatment with three or more antiretroviral agents. The antiviral effects of combinations of emtricitabine (FTC) plus tenofovir (TFV) plus antiretroviral agents of all the major drug classes were investigated. Combinations of FTC and TFV with a nonnucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulkarni R,Hluhanich R,McColl DM,Miller MD,White KL

更新日期：2014-10-01 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wingard JR,Bender WJ,Saral R,Burns WH

更新日期：1981-08-01 00:00:00

abstract：:Seventy nine strains of Yersinia enterocolitica resistant to one or more antimicrobials were analyzed for integrons. Only class 1 sul1 integrons containing aadA1a (28 strains), aadA1a-dfr1-sat1 (2 strains), and dfr1-aadA1a (1 strain) gene cassettes were found. The first two types were found in clinical isolates belong...

journal_title：Antimicrobial agents and chemotherapy

authors： Soto SM,Lobato MJ,Mendoza MC

更新日期：2003-01-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:The in vitro susceptibilities of 266 isolates of Streptococcus agalactiae determined by the agar dilution method showed that 6% of isolates were nonsusceptible to penicillin and 46% was resistant to erythromycin. Of the erythromycin-resistant isolates, 86.3% had the macrolide-lincosamide-streptogramin (MLS) resistance...

journal_title：Antimicrobial agents and chemotherapy

authors： Hsueh PR,Teng LJ,Lee LN,Ho SW,Yang PC,Luh KT

更新日期：2001-11-01 00:00:00

abstract：:The available treatments for leishmaniasis are less than optimal due to inadequate efficacy, toxic side effects, and the emergence of resistant strains, clearly endorsing the urgent need for discovery and development of novel drug candidates. Ideally, these should act via an alternative mechanism of action to avoid cr...

journal_title：Antimicrobial agents and chemotherapy

authors： Sebastián-Pérez V,Hendrickx S,Munday JC,Kalejaiye T,Martínez A,Campillo NE,de Koning H,Caljon G,Maes L,Gil C

更新日期：2018-09-24 00:00:00

abstract：:Human immunodeficiency virus (HIV) Tat and gp120 intriguingly share the feature of being basic peptides that, once released by HIV(+) cells, bind to polyanionic heparan sulfate proteoglycans (HSPGs) on target uninfected cells, contributing to the onset of AIDS-associated pathologies. To identify multitarget anti-HIV p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bugatti A,Urbinati C,Ravelli C,De Clercq E,Liekens S,Rusnati M

更新日期：2007-07-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by eit...

journal_title：Antimicrobial agents and chemotherapy

authors： Mishin VP,Hayden FG,Gubareva LV

更新日期：2005-11-01 00:00:00

abstract：:PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae IK,Jang SJ,Kim J,Jeong SH,Cho B,Lee K

更新日期：2011-03-01 00:00:00

abstract：:Viral regulatory complexes perform critical functions during virus replication and are important targets for therapeutic intervention. In HIV, the Tat and Rev proteins form complexes with multiple viral and cellular factors to direct transcription and export of the viral RNA. These complexes are composed of many prote...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakamura RL,Burlingame MA,Yang S,Crosby DC,Talbot DJ,Chui K,Frankel AD,Renslo AR

更新日期：2017-06-27 00:00:00

abstract：:Five R plasmids transferred from Asian strains of Vibrio cholerae all proved to be members of compatibility group C. A non-self-transmissible plasmid, stable in V. cholerae, was mobilized for transfer to Escherichia coli K-12 and found to be unstably inherited in that host. Plasmids of group C and P transferred to a w...

journal_title：Antimicrobial agents and chemotherapy

authors： Hedges RW,Vialard JL,Pearson NJ,O'Grady F

更新日期：1977-04-01 00:00:00

abstract：:Inhibition of Escherichia coli by isonicotinic acid hydrazide (isoniazid) is a function of the initial cell concentration, concentration of antibiotic, and chemical composition of the medium. An initial concentration of 5 x 10(5) cells/ml in a minimal medium is inhibited by 1 mM isoniazid. The E. coli cells are protec...

journal_title：Antimicrobial agents and chemotherapy

authors： Tritz GJ

更新日期：1974-03-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

更新日期：2001-05-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become a significant acute and chronic respiratory pathogen. While vancomycin is effective against MRSA, its relatively poor penetration into lung secretions and dose-limiting renal toxicity make it less effective in the respiratory setting. As inhaled administrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Waterer G,Lord J,Hofmann T,Jouhikainen T

更新日期：2020-02-21 00:00:00

abstract：:The molecular mechanisms of resistance to fluoroquinolones, tetracyclines, an aminocyclitol, macrolides, a lincosamide, a phenicol, and pleuromutilins were investigated in Mycoplasma bovis For the identification of mutations responsible for the high MICs of certain antibiotics, whole-genome sequencing of 35 M. bovis f...

journal_title：Antimicrobial agents and chemotherapy

authors： Sulyok KM,Kreizinger Z,Wehmann E,Lysnyansky I,Bányai K,Marton S,Jerzsele Á,Rónai Z,Turcsányi I,Makrai L,Jánosi S,Nagy SÁ,Gyuranecz M

更新日期：2017-01-24 00:00:00

abstract：:The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. s...

journal_title：Antimicrobial agents and chemotherapy

authors： Neyfakh AA,Borsch CM,Kaatz GW

更新日期：1993-01-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

更新日期：2010-07-01 00:00:00

abstract：:The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiu CH,Su LH,Huang YC,Lai JC,Chen HL,Wu TL,Lin TY

更新日期：2007-09-01 00:00:00

abstract：:The current treatment of chronic hepatitis C is based on pegylated alpha interferon (PEG-IFN-α) and ribavirin. The aim of this study was to identify biological and clinical variables related to IFN therapy that could predict patient outcome. The study enrolled 47 patients treated with PEG-IFN and ribavirin combined th...

journal_title：Antimicrobial agents and chemotherapy

authors： François C,Coulouarn C,Descamps V,Castelain S,Brochot E,Baron A,Duchaussoy I,Capron D,Nguyen-Khac E,Duverlie G

更新日期：2012-02-01 00:00:00

abstract：:We analyzed the didanosine (ddI) arm of the randomized, placebo-controlled Jaguar trial in order to define a genotypic score for ddI associated with virologic response. In this arm, 111 patients experiencing virologic failure received ddI in addition to their current combination therapy for 4 weeks. The impact of muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcelin AG,Flandre P,Pavie J,Schmidely N,Wirden M,Lada O,Chiche D,Molina JM,Calvez V,AI454-176 Jaguar Study Team.

更新日期：2005-05-01 00:00:00