Unusual susceptibility of a multidrug-resistant yeast strain to peptidic antifungals.

abstract：:Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental in...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T,Kamimura T,Okada N,Sakamoto H,Fukada S,Nakamoto S,Yokota Y,Miki K

更新日期：1976-07-01 00:00:00

abstract：:Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofung...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamilos G,Lewis RE,Albert N,Kontoyiannis DP

更新日期：2007-06-01 00:00:00

abstract：:beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. All strains producing a probe-type enzyme gave a positive hybridization reaction. C...

journal_title：Antimicrobial agents and chemotherapy

authors： Huovinen S,Huovinén P,Jacoby GA

更新日期：1988-02-01 00:00:00

abstract：:The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytope...

journal_title：Antimicrobial agents and chemotherapy

authors： Calame W,van der Waals R,Mattie H,van Furth R

更新日期：1989-06-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also de...

journal_title：Antimicrobial agents and chemotherapy

authors： Avanzi C,Maia RC,Benjak A,Nery JA,Sales AM,Miranda A,Duppre NC,Nogueira Brum Fontes A,Pereira da Silva T,Olmo Pinheiro R,Neves-Manta F,Moreira SJM,Busso P,Sarno EN,Suffys PN,Cole ST,Moraes MO

更新日期：2020-06-23 00:00:00

abstract：:Pseudomonas aeruginosa clinical isolate CY-1, which was resistant to ceftazidime, harbored a conjugative ca. 250-kb plasmid that contained a class 1 integron with two gene cassettes encoding OXA-32, an OXA-2- type beta-lactamase, and the aminoglycoside acetyltransferase AAC(6')Ib(9). OXA-32 differed from OXA-2 by an L...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Gerome P,De Champs C,Stephanazzi J,Naas T,Nordmann P

更新日期：2002-02-01 00:00:00

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter...

journal_title：Antimicrobial agents and chemotherapy

authors： Lartigue MF,Leflon-Guibout V,Poirel L,Nordmann P,Nicolas-Chanoine MH

更新日期：2002-12-01 00:00:00

abstract：:Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. A target area under the concentration-time curve from 0 to 24 h (AUC0-24) of 40 to 50 μg · h/ml is recommended. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong Q,Leroux S,Shi HY,Xu HY,Kou C,Khan MW,Jacqz-Aigrain E,Zhao W

更新日期：2018-04-26 00:00:00

abstract：:Numerous bacterial pathogens, particularly those that colonize fast-flow areas in the bladder and gastrointestinal tract, require motility to establish infection and spread beyond the initially colonized tissue. Vibrio cholerae strains of serogroups O1 and O139, the causative agents of the diarrheal illness cholera, e...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen L,White EL,Pathak A,Ayala JC,Wang H,Wu JH,Benitez JA,Silva AJ

更新日期：2011-09-01 00:00:00

abstract：:Fluoroquinolone antibiotics are prescribed for the treatment of Salmonella enterica infections, but resistance to this family of antibiotics is growing. Here we report that loss of the global regulatory protein cyclic AMP (cAMP) receptor protein (CRP) or its allosteric effector, cAMP, reduces susceptibility to fluoroq...

journal_title：Antimicrobial agents and chemotherapy

authors： Kary SC,Yoneda JRK,Olshefsky SC,Stewart LA,West SB,Cameron ADS

更新日期：2017-10-24 00:00:00

abstract：:Sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. They have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. This new family of compounds has also shown in vivo activity against murine Can...

journal_title：Antimicrobial agents and chemotherapy

authors： Aviles P,Pateman A,San Roman R,Guillén MJ,Gómez De Las Heras F,Gargallo-Viola D

更新日期：2001-10-01 00:00:00

abstract：:Biofilm production is an important step in the pathogenesis of Staphylococcus epidermidis polymer-associated infections and depends on the expression of the icaADBC operon leading to the synthesis of a polysaccharide intercellular adhesin. A chromosomally encoded reporter gene fusion between the ica promoter and the b...

journal_title：Antimicrobial agents and chemotherapy

authors： Rachid S,Ohlsen K,Witte W,Hacker J,Ziebuhr W

更新日期：2000-12-01 00:00:00

abstract：:Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

journal_title：Antimicrobial agents and chemotherapy

authors： Azimi PH,Dunphy MG

更新日期：1989-09-01 00:00:00

abstract：:Carbapenem resistance rates in Pseudomonas aeruginosa isolates in Colombia, as in many South American countries, are high for reasons that remain unclear. From our nationwide network, we describe the first detection of the metallo-beta-lactamase VIM-2 in clinical isolates of P. aeruginosa from multiple cities within C...

journal_title：Antimicrobial agents and chemotherapy

authors： Villegas MV,Lolans K,del Rosario Olivera M,Suarez CJ,Correa A,Queenan AM,Quinn JP,Colombian Nosocomial Resistance Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and serovar Paratyphi A (enteric fever), but there are no clinically validated MIC and disk zone size interpretative guidelines. We studied individual patient data from three randomized controlled trials (RCTs) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parry CM,Thieu NT,Dolecek C,Karkey A,Gupta R,Turner P,Dance D,Maude RR,Ha V,Tran CN,Thi PL,Be BP,Phi LT,Ngoc RN,Ghose A,Dongol S,Campbell JI,Thanh DP,Thanh TH,Moore CE,Sona S,Gaind R,Deb M,Anh HV,Van SN,

更新日期：2015-05-01 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:Conjugative transfer of R plasmids R64 and R64drd-11 has been compared in vitro and in vivo without selective pressure by antibiotics in a simplified experimental system; the ecosystem was the bowel of germfree chickens, with the host bacteria almost isogenic, and the plasmids differing only in their conjugative trans...

journal_title：Antimicrobial agents and chemotherapy

authors： Sansonetti P,Lafont JP,Jaffé-Brachet A,Guillot JF,Chaslus-Dancla E

更新日期：1980-03-01 00:00:00

abstract：:The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies. Parasitic pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan WJ Jr,Dixon SE,Li C,Striepen B,Queener SF

更新日期：2005-06-01 00:00:00

abstract：:Isolates of Aspergillus fumigatus that demonstrate resistance to itraconazole (ITZ) have been described previously; however, the prevalence and clinical significance of ITZ resistance are not completely understood. In this study we assessed the ITZ susceptibilities of 128 A. fumigatus isolates that caused invasive inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Balajee SA,Weaver M,Imhof A,Gribskov J,Marr KA

更新日期：2004-04-01 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of colistin combined ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tan JH,Vidaillac C,Yam JKH,Chua SL,Givskov M,Yang L

更新日期：2017-06-27 00:00:00

abstract：:The role of pyrazinamide in the current treatment of multidrug-resistant (MDR) tuberculosis (TB) is uncertain. From a territory-wide registry of MDR-TB cases diagnosed between 1995 and 2009, we assembled a cohort of 194 patients with MDR pulmonary TB given fluoroquinolone-containing regimens. Stratified by pyrazinamid...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang KC,Leung CC,Yew WW,Leung EC,Leung WM,Tam CM,Zhang Y

更新日期：2012-11-01 00:00:00

abstract：:In a dose-ranging study of amprenavir (formerly 141W94), an inhibitor of the protease enzyme of human immunodeficiency virus (HIV) type 1, single-dose and steady-state pharmacokinetic parameters were estimated from plasma samples collected on day 1 and during week 3, respectively. Amprenavir was administered on either...

journal_title：Antimicrobial agents and chemotherapy

authors： Sadler BM,Gillotin C,Lou Y,Stein DS

更新日期：2001-01-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:The telithromycin susceptibility of 210 erythromycin-resistant pneumococci was tested with the agar diffusion method. Twenty-six erm(B)-positive isolates showed heterogeneous resistance to telithromycin, which was manifested by the presence of colonies inside the inhibition zone. When these cells were cultured and tes...

journal_title：Antimicrobial agents and chemotherapy

authors： Rantala M,Haanperä-Heikkinen M,Lindgren M,Seppälä H,Huovinen P,Jalava J

更新日期：2006-05-01 00:00:00

abstract：:This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

更新日期：2010-09-01 00:00:00

abstract：:The aminoglycoside-modifying enzymes present in the first 120 clinical isolates harboring extended-spectrum beta-lactamases isolated in Spain were studied. Most of these isolates (84%) were gentamicin resistant. The enzymes most frequently associated and cotransferred with SHV-2 or TEM-type beta-lactamases were AAC(3)...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandez-Rodriguez A,Canton R,Perez-Diaz JC,Martinez-Beltran J,Picazo JJ,Baquero F

更新日期：1992-11-01 00:00:00

abstract：:Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. Pseudomonas aeruginosa is a particularly difficult pathogen to treat effectively because of the plethora of resistance mechanisms it carries. Fosfomycin is an agent discovered ci...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Neely MN,Yamada WM,Duncanson B,Brown D,Maynard M,Vicchiarelli M,Louie A

更新日期：2018-11-26 00:00:00