In vitro and in vivo evaluation of ceftezole, a new cephalosporin derivative.

abstract：:The present study investigated the effect of a model urease-binding polysaccharide in combination with a histamine H(2) receptor antagonist on Helicobacter pylori colonization in vivo. Euthymic hairless mice were treated daily with dextran sulfate via drinking water and/or famotidine via intragastric gavage starting a...

journal_title：Antimicrobial agents and chemotherapy

authors： Icatlo FC Jr,Kimura N,Goshima H,Kodama Y

更新日期：2000-09-01 00:00:00

abstract：:Thirteen derivatives of the Streptococcus pneumoniae TIGR4 strain in which putative drug efflux pumps were genetically inactivated were constructed and characterized. The results indicate that two linked genes encoding the ABC-type transporters SP2073 and SP2075 function together to confer intrinsic resistance to a se...

journal_title：Antimicrobial agents and chemotherapy

authors： Robertson GT,Doyle TB,Lynch AS

更新日期：2005-11-01 00:00:00

abstract：:The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

更新日期：2017-06-27 00:00:00

abstract：:The time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, L-671,329 and cilofungin, were measured in male rhesus monkeys (Macaca mulatta) and in female DBA/2 mice. The antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% po...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundelof JG,Hajdu R,Cleare WJ,Onishi J,Kropp H

更新日期：1992-03-01 00:00:00

abstract：:The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, n...

journal_title：Antimicrobial agents and chemotherapy

authors： Staehli Hodel EM,Csajka C,Ariey F,Guidi M,Kabanywanyi AM,Duong S,Decosterd LA,Olliaro P,Beck HP,Genton B

更新日期：2013-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) genotype (GT) 2 represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to interferon-α, the presence of polymorphisms in NS5A can impact efficacy of NS5A inh...

journal_title：Antimicrobial agents and chemotherapy

authors： Asante-Appiah E,Ingravallo P,McMonagle P,Bystol K,Xia E,Curry S,Qiu P,Black S,Chase R,Liu R,Lahser F

更新日期：2019-09-16 00:00:00

abstract：:Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy volunteers, using biomarkers for safety and efficacy. Subjects were ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallis RS,Jakubiec W,Kumar V,Bedarida G,Silvia A,Paige D,Zhu T,Mitton-Fry M,Ladutko L,Campbell S,Miller PF

更新日期：2011-02-01 00:00:00

abstract：:Helicobacter pylori is killed in vitro by polyoxyethylene acyl esters and ethers similar to simethicone emulsifiers in therapeutic antifoams. The MBC of these compounds for Helicobacter pylori was less than 20 micrograms/ml, while other gram-negative bacteria were unaffected by much higher concentrations of up to 50 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Kane AV,Plaut AG

更新日期：1996-02-01 00:00:00

abstract：:The response of tolerant Streptococcus sanguis and nontolerant Streptococcus mitis infections to penicillin therapy was compared in the rabbit model of endocarditis. The minimal inhibitory and bactericidal concentrations of penicillin were 0.1 and 0.1 mug/ml, respectively, for S. mitis and 0.05 and 6.2 mug/ml, respect...

journal_title：Antimicrobial agents and chemotherapy

authors： Lowy FD,Neuhaus EG,Chang DS,Steigbigel NH

更新日期：1983-01-01 00:00:00

abstract：:The in vitro susceptibility of 406 clinical isolates to BMY-28142, a new semisynthetic cephem, was evaluated and compared with cefpimizole, HR 810, ceftazidime, cefotaxime, moxalactam, and cefoperazone in a broth microdilution assay. On a weight basis, the activity of BMY-28142 against Escherichia coli, Proteus specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuji A,Maniatis A,Bertram MA,Young LS

更新日期：1985-04-01 00:00:00

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00

abstract：:Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkevich NV,Basu S,Rudge TL Jr,Clement KH,Chakrabarti AC,Aimes RT,Nabors GS,Skiadopoulos MH,Ionin B

更新日期：2013-11-01 00:00:00

abstract：:Cytomegalovirus can cause debilitating and life-threatening disease in newborns infected in utero and immunocompromised individuals, including transplant recipients. RG7667 is a unique combination of two monoclonal antibodies that binds glycoprotein complexes on the surface of cytomegalovirus and inhibits its entry in...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishida JH,Burgess T,Derby MA,Brown PA,Maia M,Deng R,Emu B,Feierbach B,Fouts AE,Liao XC,Tavel JA

更新日期：2015-08-01 00:00:00

abstract：:Telithromycin MICs for 13,874 Streptococcus pneumoniae isolates collected in the first 3 years of the global PROTEKT study (1999 to 2003) were studied. There was no change in the distribution of telithromycin MICs over this period, even in countries where telithromycin is in use. The telithromycin MICs for 10 isolates...

journal_title：Antimicrobial agents and chemotherapy

authors： Farrell DJ,Felmingham D

更新日期：2004-05-01 00:00:00

abstract：:Mammalian serum amyloid A (SAA) is a major acute phase protein that shows a massive increase in plasma concentration during inflammation. In the present study, we demonstrate that the expression of mouse SAA1 in serum was increased when infected with Candida albicans, a major human fungal pathogen, in a systemic infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Gong J,Wu J,Ikeh M,Tao L,Zhang Y,Bing J,Nobile CJ,Huang G

更新日期：2019-12-20 00:00:00

abstract：:In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of beta-lactamase genes and ftsI gene mutations. For all isolates, the minimal co...

journal_title：Antimicrobial agents and chemotherapy

authors： Kishii K,Chiba N,Morozumi M,Ono A,Ida T,Ubukata K

更新日期：2010-09-01 00:00:00

abstract：:We undertook a prospective, randomized open comparison of the broad-spectrum cephalosporins cefepime and ceftazidime in treatment of hospitalized subjects with skin or wound infections and complicated nosocomial urinary tract infections. Cefepime treatment (dosage, 2.0 g intravenously twice daily for 4 to 28 days) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez-Gomez G

更新日期：1991-11-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe sepsis (66 of whom ...

journal_title：Antimicrobial agents and chemotherapy

authors： Suputtamongkol Y,Intaranongpai S,Smith MD,Angus B,Chaowagul W,Permpikul C,Simpson JA,Leelarasamee A,Curtis L,White NJ

更新日期：2000-03-01 00:00:00

abstract：:Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes i...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Tenover FC,Koehler TM

更新日期：2004-12-01 00:00:00

abstract：:The pharmacodynamics of gemifloxacin against Streptococcus pneumoniae were investigated in a dilutional pharmacodynamic model of infection. Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every...

journal_title：Antimicrobial agents and chemotherapy

authors： MacGowan AP,Rogers CA,Holt HA,Wootton M,Bowker KE

更新日期：2001-10-01 00:00:00

abstract：:Real-time quantitative PCR was used to measure expression levels of genes encoding efflux pumps, ERG11 and two control genes, ACT1 and PMA1, in a collection of 14 fluconazole-susceptible Candida albicans isolates. For each gene, average expression levels and variations within the population were determined. These valu...

journal_title：Antimicrobial agents and chemotherapy

authors： Chau AS,Mendrick CA,Sabatelli FJ,Loebenberg D,McNicholas PM

更新日期：2004-06-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV agent with potent in vitro and in vivo activity. RFI-641 is active against both RSV type A and B strains. The viral specif...

journal_title：Antimicrobial agents and chemotherapy

authors： Huntley CC,Weiss WJ,Gazumyan A,Buklan A,Feld B,Hu W,Jones TR,Murphy T,Nikitenko AA,O'Hara B,Prince G,Quartuccio S,Raifeld YE,Wyde P,O'Connell JF

更新日期：2002-03-01 00:00:00

abstract：:The continued evolution of bacterial resistance to the β-lactam class of antibiotics has necessitated countermeasures to ensure continued effectiveness in the treatment of infections caused by bacterial pathogens. One relatively successful approach has been the development of new β-lactam analogs with advantages over ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cotroneo N,Rubio A,Critchley IA,Pillar C,Pucci MJ

更新日期：2020-07-22 00:00:00

abstract：:The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most ...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan MY,Gruninger RP,Nelson SM,Klicker RE

更新日期：1982-05-01 00:00:00

abstract：:The aim of this study was to reveal population pharmacokinetics and assess the efficacies of various dosage regimens of sulbactam in terms of the probability of target attainment with this agent over a range of MICs. Monte Carlo simulations were performed to determine the probability of attaining specific pharmacodyna...

journal_title：Antimicrobial agents and chemotherapy

authors： Jaruratanasirikul S,Wongpoowarak W,Aeinlang N,Jullangkoon M

更新日期：2013-07-01 00:00:00

abstract：:A rapid (6-7 hr), modified Kirby-Bauer disk-susceptibility method, by which derivatives of tetrazolium dyes are used to enhance delineation between areas of growth and zones of inhibition, has been developed. Inoculated petri plates, prepared by the Kirby-Bauer method, were sprayed, after 6 to 7 hr of incubation (37 C...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyle VJ,Fancher ME,Ross RW Jr

更新日期：1973-03-01 00:00:00

abstract：:Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time cur...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Andes DR

更新日期：2019-10-22 00:00:00

abstract：:Topical foscarnet (PFA) and acyclovir (ACV) were compared in the dorsal cutaneous guinea pig model of herpes simplex virus type 1 infection. The relative order of efficacy was PFA cream greater than ACV cream greater than ACV ointment. In vitro studies demonstrated that PFA and ACV formulated in cream vehicles penetra...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1986-07-01 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00

abstract：:The susceptibilities to 20 antimicrobial agents of Bordetella bronchiseptica variants in C mode and degraded phases were compared with those of their parents in X mode. Increases in MICs of 4- to 32-fold were observed for ampicillin, carbenicillin, erythromycin, novobiocin, rifampin, chloramphenicol, nalidixic acid, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa H,Isayama Y,Ohmae K

更新日期：1988-12-01 00:00:00