In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm.

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:Forty-nine clinical isolates of multidrug-resistant Acinetobacter baumannii were obtained from 12 hospitals in 7 prefectures throughout Japan. Molecular phylogenetic analysis revealed the clonal spread of A. baumannii sequence type 208 (ST208) and ST455 isolates harboring the armA gene and ST512 harboring the armA and...

journal_title：Antimicrobial agents and chemotherapy

authors： Tada T,Miyoshi-Akiyama T,Shimada K,Shimojima M,Kirikae T

更新日期：2014-05-01 00:00:00

abstract：:The integrase inhibitor raltegravir (RAL) is currently used for the treatment of both treatment-naïve and treatment-experienced HIV-1-infected patients. Elvitegravir (EVG) is in late phases of clinical development. Since significant cross-resistance between RAL and EVG is observed, there is a need for second-generatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Wesenbeeck L,Rondelez E,Feyaerts M,Verheyen A,Van der Borght K,Smits V,Cleybergh C,De Wolf H,Van Baelen K,Stuyver LJ

更新日期：2011-01-01 00:00:00

abstract：:Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo. For three cyclosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Ptak RG,Gallay PA,Jochmans D,Halestrap AP,Ruegg UT,Pallansch LA,Bobardt MD,de Béthune MP,Neyts J,De Clercq E,Dumont JM,Scalfaro P,Besseghir K,Wenger RM,Rosenwirth B

更新日期：2008-04-01 00:00:00

abstract：:We investigated both the structural and functional consequences of modifying the hydrophobic, lipopeptide-mimetic oligo-acyl-lysine (OAK) N(alpha)-hexadecanoyl-l-lysyl-l-lysyl-aminododecanoyl-l-lysyl-amide (c(16)KKc(12)K) to its unsaturated analog hexadecenoyl-KKc(12)K [c(16(omega7))KKc(12)K]. Despite similar tendenci...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarig H,Rotem S,Ziserman L,Danino D,Mor A

更新日期：2008-12-01 00:00:00

abstract：:The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares ...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo M,Hishinuma T,Katayama Y,Cui L,Kapi M,Hiramatsu K

更新日期：2011-09-01 00:00:00

abstract：:The pharmacodynamic properties of levofloxacin (an optically active isomer of ofloxacin), ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA 1199 and MRSA 494, respectively)...

journal_title：Antimicrobial agents and chemotherapy

authors： Kang SL,Rybak MJ,McGrath BJ,Kaatz GW,Seo SM

更新日期：1994-12-01 00:00:00

abstract：:Detection of bacterial growth by measuring the release of (14)CO(2) from the metabolism of uniformly labeled (14)C-glucose has proven to be accurate, sensitive, and rapid. The inhibition of glucose metabolism by antibiotics as an index of bacterial susceptibility was evaluated based on radiometric methodology. Bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLand FH

更新日期：1972-11-01 00:00:00

abstract：:In Portugal erythromycin resistance of 26.6% (n = 352) remained constant during 1998 to 2003, however in 1998 the MLS(B) phenotype dominated (85%), whereas in 2003 the M phenotype prevailed (77%). A decline in T12/emm22 MLS(B) isolates could partially explain the drop in this phenotype, but the rise of the M phenotype...

journal_title：Antimicrobial agents and chemotherapy

authors： Silva-Costa C,Ramirez M,Melo-Cristino J,Portuguese Surveillance Group for the Study of Respiratory Pathogens.

更新日期：2005-05-01 00:00:00

abstract：:Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozniewski A,Weber M,De Korwin JD,Conroy MC,Franck P,Floquet J,Le Faou A,Burdin JC

更新日期：1995-03-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

更新日期：1991-03-01 00:00:00

abstract：:Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft DS

更新日期：1997-03-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children and other high-risk populations. RSV nucleoprotein (N) is essential for virus assembly and replication as part of the viral ribonucleoprotein (RNP) complex. RSV604 was a putative N inhibitor in phase 2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Challa S,Scott AD,Yuzhakov O,Zhou Y,Tiong-Yip CL,Gao N,Thresher J,Yu Q

更新日期：2015-02-01 00:00:00

abstract：:We conducted a retrospective study of 2,149 clinicalSalmonellastrains to help document the historical emergence of antimicrobial resistance. There were significant increases in resistance to older drugs, including ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline, which were most common inS...

journal_title：Antimicrobial agents and chemotherapy

authors： Tadesse DA,Singh A,Zhao S,Bartholomew M,Womack N,Ayers S,Fields PI,McDermott PF

更新日期：2016-03-25 00:00:00

abstract：:Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A-G), which differ between 35% to 68% in amino acid sequence, necessitates the development of serot...

journal_title：Antimicrobial agents and chemotherapy

authors： Snow DM,Riling K,Kimbler A,Espinoza Y,Wong D,Pham K,Martinez Z,Kraus CN,Conrad F,Garcia-Rodriguez C,Cobb RR,Marks JD,Tomic MT

更新日期：2019-10-07 00:00:00

abstract：:Foscarnet is widely used for the treatment of acyclovir-resistant herpesvirus infections, and foscarnet-resistant herpesvirus infections are a serious concern in immunocompromised patients. Twenty-seven single-plaque isolates of herpes simplex virus type 1 (HSV-1) resistant to foscarnet were selected from foscarnet- a...

journal_title：Antimicrobial agents and chemotherapy

authors： Saijo M,Suzutani T,Morikawa S,Kurane I

更新日期：2005-02-01 00:00:00

abstract：:Cefodizime, an iminomethoxy aminothiazolyl cephalosporin similar to moxalactam and ceftazidime, was less active (minimal inhibitory concentration, 1.6 to 12 micrograms) than cefazolin or cefotaxime against Staphylococcus aureus and Staphylococcus epidermidis. It inhibited Haemophilus and Neisseria spp. at less than 0....

journal_title：Antimicrobial agents and chemotherapy

authors： Scully BE,Jules K,Neu HC

更新日期：1983-06-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. He...

journal_title：Antimicrobial agents and chemotherapy

authors： Kalle AM,Rizvi A

更新日期：2011-01-01 00:00:00

abstract：:Doravirine (DOR, formerly known as MK-1439) is a human immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is currently in phase 2b clinical trials. In vitro resistance selection of subtype B virus (MT4-green fluorescent protein [GFP] cells), as well as subtype A and C viru...

journal_title：Antimicrobial agents and chemotherapy

authors： Feng M,Wang D,Grobler JA,Hazuda DJ,Miller MD,Lai MT

更新日期：2015-01-01 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:Helicobacter pylori is killed in vitro by polyoxyethylene acyl esters and ethers similar to simethicone emulsifiers in therapeutic antifoams. The MBC of these compounds for Helicobacter pylori was less than 20 micrograms/ml, while other gram-negative bacteria were unaffected by much higher concentrations of up to 50 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Kane AV,Plaut AG

更新日期：1996-02-01 00:00:00

abstract：:Treatment options are limited for implant-associated infections (IAI) that are mainly caused by biofilm-forming staphylococci. We report here on the activity of the serrulatane compound 8-hydroxyserrulat-14-en-19-oic acid (EN4), a diterpene isolated from the Australian plant Eremophila neglecta. EN4 elicited antimicro...

journal_title：Antimicrobial agents and chemotherapy

authors： Nowakowska J,Griesser HJ,Textor M,Landmann R,Khanna N

更新日期：2013-01-01 00:00:00

abstract：:Despite the development of novel antibiotics active against Gram-positive bacteria, vancomycin generally remains the first treatment, although rapidly achieving concentrations associated with maximal efficacy provides an unresolved challenge. The objective of this study was to conduct a population pharmacokinetic anal...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts JA,Taccone FS,Udy AA,Vincent JL,Jacobs F,Lipman J

更新日期：2011-06-01 00:00:00

abstract：:Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Zarember KA,Cruz AR,Huang CY,Gallin JI

更新日期：2009-06-01 00:00:00

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort ...

journal_title：Antimicrobial agents and chemotherapy

authors： Grégoire M,Dailly E,Le Turnier P,Garot D,Guimard T,Bernard L,Tattevin P,Vandamme YM,Hoff J,Lemaitre F,Verdier MC,Deslandes G,Bellouard R,Sébille V,Chiffoleau A,Boutoille D,Navas D,Asseray N

更新日期：2019-08-23 00:00:00

abstract：:The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Swidergall M,Ernst AM,Ernst JF

更新日期：2013-08-01 00:00:00

abstract：:In view of increasing health threats from multiresistant pathogens, antimicrobial peptides (AMPs) and, specifically, proline-rich AMPs (PrAMPs) have been investigated in animal models. PrAMPs enter bacteria via the ABC transporter SbmA and inhibit intracellular targets. We used phage transduction (Tn10 insertion) to s...

journal_title：Antimicrobial agents and chemotherapy

authors： Krizsan A,Knappe D,Hoffmann R

更新日期：2015-10-01 00:00:00

abstract：:This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studies of patients infected with genotype 1 chronic HCV. This analysis in...

journal_title：Antimicrobial agents and chemotherapy

authors： Reddy MB,Morcos PN,Le Pogam S,Ou Y,Frank K,Lave T,Smith P

更新日期：2012-06-01 00:00:00