Metabolic inhibition as an index of bacterial susceptibility to drugs.

abstract：:The oxazolidinone linezolid represents a new antibacterial class of potential benefit in managing multidrug-resistant gram-positive infections, including those caused by Streptococcus pneumoniae. In a gerbil model of acute otitis media (AOM) induced by either penicillin-resistant S. pneumoniae (PRSP; amoxicillin MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Humphrey WR,Shattuck MH,Zielinski RJ,Kuo MS,Biermacher JJ,Smith DP,Jensen JL,Schaadt RD,Zurenko GE,Richards IM

更新日期：2003-04-01 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:The gram-positive bacterium Streptomyces noursei ATCC 11455 produces a complex mixture of polyene macrolides generally termed nystatins. Although the structures for nystatins A(1) and A(3) have been reported, the identities of other components of the nystatin complex remain obscure. Analyses of the culture extract fro...

journal_title：Antimicrobial agents and chemotherapy

authors： Bruheim P,Borgos SE,Tsan P,Sletta H,Ellingsen TE,Lancelin JM,Zotchev SB

更新日期：2004-11-01 00:00:00

abstract：:Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens. Here, we explored increasing the dose intensity of poly...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuji BT,Landersdorfer CB,Lenhard JR,Cheah SE,Thamlikitkul V,Rao GG,Holden PN,Forrest A,Bulitta JB,Nation RL,Li J

更新日期：2016-06-20 00:00:00

abstract：:Resistance to 5-fluorocytosine was studied in 137 independent Candida albicans clinical isolates. Seventy-eight isolates (57%) were susceptible; 51 isolates (37%) were partially resistant; 8 isolates (6%) were highly resistant. All partially resistant isolates gave rise to variants which were highly resistant. Some su...

journal_title：Antimicrobial agents and chemotherapy

authors： Defever KS,Whelan WL,Rogers AL,Beneke ES,Veselenak JM,Soll DR

更新日期：1982-11-01 00:00:00

abstract：:We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of m...

journal_title：Antimicrobial agents and chemotherapy

authors： Spreghini E,Orlando F,Santinelli A,Pisa E,Loretelli C,Manso E,Milici ME,Scalise G,Barchiesi F

更新日期：2009-09-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC(50)s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in B...

journal_title：Antimicrobial agents and chemotherapy

authors： Yardley V,Gamarro F,Croft SL

更新日期：2010-12-01 00:00:00

abstract：:The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was investigated. Phagocytes treated with SM-1213 demonstrated an enhanced ability to inhibit intracellular hyphal formation and elon...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrison CJ,Gordon P,Hashimoto T

更新日期：1984-07-01 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:The substituted benzimidazole omeprazole, used for the treatment of human peptic ulcer disease, inhibits the growth of the metronidazole-resistant bovine pathogen Tritrichomonas foetus in vitro (MIC at which the growth of parasite cultures is inhibited by 50%, 22 microg/ml [63 microM]). The antitrichomonad activity ap...

journal_title：Antimicrobial agents and chemotherapy

authors： Sutak R,Tachezy J,Kulda J,Hrdý I

更新日期：2004-06-01 00:00:00

abstract：:Community-associated infections due to Escherichia coli producing CTX-M-type extended-spectrum β-lactamases are increasingly recognized in the United States. The bla(CTX-M) genes are frequently carried on IncF group plasmids. In this study, bla(CTX-M-15)-harboring plasmids pCA14 (sequence type 131 [ST131]) and pCA28 (...

journal_title：Antimicrobial agents and chemotherapy

authors： Li JJ,Spychala CN,Hu F,Sheng JF,Doi Y

更新日期：2015-01-01 00:00:00

abstract：:The ability of novobiocin to eliminate (cure) the wild-type plasmid pMG110 from Escherichia coli has been compared with that of other inhibitors of the gyrase B subunit and of the gyrase A subunit. Novobiocin eliminated pMG110 , producing over 99% plasmid loss at concentrations two- to eightfold below the MIC for bact...

journal_title：Antimicrobial agents and chemotherapy

authors： Hooper DC,Wolfson JS,McHugh GL,Swartz MD,Tung C,Swartz MN

更新日期：1984-05-01 00:00:00

abstract：:A novel stilbene glycoside [piceid-(1-->6)-beta-d-glucopyranoside; PBG] from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in a 4-day early infection, a repository evaluation, and an established infection, with a significant mean surv...

journal_title：Antimicrobial agents and chemotherapy

authors： Park WH,Lee SJ,Moon HI

更新日期：2008-09-01 00:00:00

abstract：:Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

journal_title：Antimicrobial agents and chemotherapy

authors： Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

更新日期：2017-03-24 00:00:00

abstract：:CL 188,624, CL 190,294, and CL 191,121 are novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems. The in vitro antibacterial activities of these THF carbapenems were evaluated and compared with those of biapenem, imipenem, and meropenem against 554 recent clinical isolates obtained from geographically dis...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Petersen PJ,Jacobus NV,Lin YI,Bitha P,Testa RT

更新日期：1999-03-01 00:00:00

abstract：:The recent escalation of occurrences of carbapenem-resistant Pseudomonas aeruginosa has been recognized globally and threatens to erode the widespread clinical utility of the carbapenem class of compounds for this prevalent health care-associated pathogen. Here, we compared the in vitro inhibitory activity of ceftazid...

journal_title：Antimicrobial agents and chemotherapy

authors： Grupper M,Sutherland C,Nicolau DP

更新日期：2017-09-22 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00

abstract：:The three direct-acting antiviral agent (3D) regimen is a novel combination of direct-acting antiviral agents (DAAs) that has proven effective for the treatment of hepatitis C virus (HCV) infection. Given the potential for coadministration in patients with human immunodeficiency virus infection, possible drug interact...

journal_title：Antimicrobial agents and chemotherapy

authors： Khatri A,Dutta S,Dunbar M,Podsadecki T,Trinh R,Awni W,Menon R

更新日期：2016-04-22 00:00:00

abstract：:Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were classified into type A and type B, based on the degrees of changes in their susceptibilities. Type A mutants were four to eight times more resistant to ofloxacin, erythromycin, and new zwitterion...

journal_title：Antimicrobial agents and chemotherapy

authors： Masuda N,Gotoh N,Ohya S,Nishino T

更新日期：1996-04-01 00:00:00

abstract：:Acyclovir [9-(2-hydroxyethoxymethyl)guanine] (ACV), a potent antiviral compound, was phosphorylated to the same extent by extracts from untreated and iododeoxyuridine-treated Epstein-Barr virus-containing latent D98/HR-1 somatic hybrid cells. ATP was the preferred phosphate donor over other nucleoside triphosphates. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Datta AK,Pagano JS

更新日期：1983-07-01 00:00:00

abstract：:Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1,10-phenanthrolene, but not endoproteinase inhibitors, blocked enzymatic...

journal_title：Antimicrobial agents and chemotherapy

authors： Okhuysen PC,Chappell CL,Kettner C,Sterling CR

更新日期：1996-12-01 00:00:00

abstract：:Granulocytopenia is a complication of human immunodeficiency virus disease, as well as a toxic manifestation of zidovudine therapy. To evaluate pharmacokinetic and pharmacodynamic relationships, 11 AIDS-AIDS-related complex patients who had developed zidovudine-associated granulocytopenia (mean absolute neutrophil cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Hewitt RG,Morse GD,Lawrence WD,Maliszewski ML,Santora J,Bartos L,Bonnem E,Poiesz B

更新日期：1993-03-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a frequent cause of in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bæk KT,Gründling A,Mogensen RG,Thøgersen L,Petersen A,Paulander W,Frees D

更新日期：2014-08-01 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00

abstract：:Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI...

journal_title：Antimicrobial agents and chemotherapy

authors： Gobert JM,Remington KM,Zhu YQ,North TW

更新日期：1994-04-01 00:00:00

abstract：:The increasing use of carbapenems for treating multidrug-resistant (MDR) Gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Serine and metallo-β-lactamases (MBLs) that hydrolyze carbapenems have become prevalent and endemic in some countries...

journal_title：Antimicrobial agents and chemotherapy

authors： Bradford PA,Kazmierczak KM,Biedenbach DJ,Wise MG,Hackel M,Sahm DF

更新日期：2015-12-14 00:00:00

abstract：:The echinocandins are a class of semisynthetic natural products that target β-1,3-glucan synthase (GS). Their proven clinical efficacy combined with minimal safety issues has made the echinocandins an important asset in the management of fungal infection in a variety of patient populations. However, the echinocandins ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker SS,Xu Y,Triantafyllou I,Waldman MF,Mendrick C,Brown N,Mann P,Chau A,Patel R,Bauman N,Norris C,Antonacci B,Gurnani M,Cacciapuoti A,McNicholas PM,Wainhaus S,Herr RJ,Kuang R,Aslanian RG,Ting PC,Black TA

更新日期：2011-11-01 00:00:00

abstract：:The production of Klebsiella pneumoniae carbapenemases (KPCs) by Enterobacteriaceae has become a significant problem in recent years. To identify factors that could predict isolation of KPC-producing K. pneumoniae (KPCKP) in clinical samples from hospitalized patients, we conducted a retrospective, matched (1:2) case-...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Tumietto F,Del Bono V,De Rosa FG,Bassetti M,Losito AR,Tedeschi S,Saffioti C,Corcione S,Giannella M,Raffaelli F,Pagani N,Bartoletti M,Spanu T,Marchese A,Cauda R,Viscoli C,Viale P

更新日期：2014-06-01 00:00:00