Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.

abstract：:Dihydroorotate dehydrogenase (DHOD) is a pyrimidine biosynthetic enzyme which is usually directly linked to the mitochondrial respiratory chain. Antimalarial naphthoquinones such as atovaquone (566c80) inhibit malarial DHOD by inhibiting electron transport. Since atovaquone also has therapeutic activity against Pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Ittarat I,Asawamahasakda W,Bartlett MS,Smith JW,Meshnick SR

更新日期：1995-02-01 00:00:00

abstract：:Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial did not show that Carraguard is effective in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Romero JA,Abraham CJ,Rodriguez A,Kizima L,Jean-Pierre N,Menon R,Begay O,Seidor S,Ford BE,Gil PI,Peters J,Katz D,Robbiani M,Zydowsky TM

更新日期：2012-01-01 00:00:00

abstract：:The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

更新日期：2015-12-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:The interaction between four fluoroquinolones (ciprofloxacin, norfloxacin, pefloxacin, and ofloxacin) and biofilms of Pseudomonas aeruginosa in wells of microtiter plates and on segments of vascular catheters were studied in an in vitro model of vascular catheter colonization. Subinhibitory concentrations (one-half, o...

journal_title：Antimicrobial agents and chemotherapy

authors： Yassien M,Khardori N,Ahmedy A,Toama M

更新日期：1995-10-01 00:00:00

abstract：:The judicious use of perioperative antibiotic prophylaxis reduces the infectious complications of surgery. However, increased bacterial resistance within hospitals may make antibiotic prophylaxis less effective in the future and alternative strategies are needed. New immunomodulatory agents might prevent wound infecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kernodle DS,Gates H,Kaiser AB

更新日期：1998-03-01 00:00:00

abstract：:Halocidin is an antimicrobial peptide found in the tunicate. A series of experiments were previously conducted in an attempt to develop a novel antibiotic derived from halocidin, as the peptide was determined to evidence profound antimicrobial activity against a variety of antibiotic-resistant microbes, with significa...

journal_title：Antimicrobial agents and chemotherapy

authors： Jang WS,Lee SC,Lee YS,Shin YP,Shin KH,Sung BH,Kim BS,Lee SH,Lee IH

更新日期：2007-11-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 pl...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernandes MR,McCulloch JA,Vianello MA,Moura Q,Pérez-Chaparro PJ,Esposito F,Sartori L,Dropa M,Matté MH,Lira DP,Mamizuka EM,Lincopan N

更新日期：2016-09-23 00:00:00

abstract：:In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. No bacterial stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Stark CA,Edlund C,Sjöstedt S,Kristensen G,Nord CE

更新日期：1993-08-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:Isonicotinic acid hydrazide (isoniazid; INH) inhibition of mycolic acid synthesis was studied by using cell extracts from both INH-sensitive and -resistant strains of Mycobacterium aurum. The cell extract of the INH-sensitive strain was inhibited by INH, while the preparation from the INH-resistant strain was not. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Quémard A,Lacave C,Lanéelle G

更新日期：1991-06-01 00:00:00

abstract：:We compared the kinetics of amphotericin B (AMB) lung accumulation and fungal clearance by liposomal amphotericin B (L-AMB) and amphotericin B lipid complex (ABLC) in a neutropenic murine model of invasive pulmonary mucormycosis (IPM). Immunosuppressed BALB/c mice were inoculated with 1 x 10(6) Rhizopus oryzae spores ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis RE,Albert ND,Liao G,Hou J,Prince RA,Kontoyiannis DP

更新日期：2010-03-01 00:00:00

abstract：:The in vitro activity of GR-20263, a new aminothiazolyl cephalosporin, was compared with the activities of other beta-lactam antibiotics by using 800 clinical bacterial isolates. GR-20263 was highly active (inhibition of 90% of the isolates between 0.03 and 1 microgram/ml) against the common Enterobacteriaceae and 5 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L,Verhaegen J

更新日期：1980-05-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:We tested the activities of anidulafungin and other antifungal agents against clinical isolates of different fungal species. For Candida species, high sessile MIC₉₀s (SMIC₉₀s) were obtained for fluconazole, voriconazole, and amphotericin B, whereas the anidulafungin SMIC₉₀s were very low, as were those for caspofungin...

journal_title：Antimicrobial agents and chemotherapy

authors： Fiori B,Posteraro B,Torelli R,Tumbarello M,Perlin DS,Fadda G,Sanguinetti M

更新日期：2011-06-01 00:00:00

abstract：:Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksey RC,Facklam RR,Thornsberry C

更新日期：1978-04-01 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Niece KL,Akers KS

更新日期：2015-09-01 00:00:00

abstract：:Treatment of mucocutaneous and cutaneous Candida albicans infections with photosensitizing agents and light, termed photodynamic therapy (PDT), offers an alternative to conventional treatments. Initial studies using the clinically approved photosensitizer Photofrin demonstrated the susceptibility of C. albicans to its...

journal_title：Antimicrobial agents and chemotherapy

authors： Chabrier-Roselló Y,Foster TH,Pérez-Nazario N,Mitra S,Haidaris CG

更新日期：2005-10-01 00:00:00

abstract：:Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Fuchs PC

更新日期：1991-06-01 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:Conventional therapy for human cytomegalovirus (CMV) relies on inhibition of the viral DNA polymerase. Ganciclovir (GCV) is the first-line therapy, but when GCV-resistant strains emerge, alternative therapies are extremely limited and are associated with significant toxicities. Combination of anti-CMV agents that act ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai H,Kapoor A,He R,Venkatadri R,Forman M,Posner GH,Arav-Boger R

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

更新日期：2005-12-01 00:00:00

abstract：:The influence of a mission hospital on the evolution of antibiotic resistance in coliform bacteria from a remote antibiotic-free Xhosa community and environment is described. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Burt SJ,Woods DR

更新日期：1976-09-01 00:00:00

abstract：:The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

journal_title：Antimicrobial agents and chemotherapy

authors： Fick RB Jr,Alexander MR,Prince RA,Kasik JE

更新日期：1987-05-01 00:00:00

abstract：:Beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae have been emerging in some countries, including Japan. The Clinical and Laboratory Standards Institute has only a susceptible MIC breakpoint (< or = 1 microg/ml) for piperacillin-tazobactam and a disclaimer comment that BLNAR H. in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirakata Y,Ohmori K,Mikuriya M,Saika T,Matsuzaki K,Hasegawa M,Hatta M,Yamamoto N,Kunishima H,Yano H,Kitagawa M,Arai K,Kawakami K,Kobayashi I,Jones RN,Kohno S,Yamaguchi K,Kaku M

更新日期：2009-10-01 00:00:00

abstract：:Polymyxin B nonapeptide, derived by cleavage of the fatty acyl diaminobutyric acid from polymyxin B, is considerably less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. The peptide rendered all 53 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ofek I,Cohen S,Rahmani R,Kabha K,Tamarkin D,Herzig Y,Rubinstein E

更新日期：1994-02-01 00:00:00