Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections.

abstract：:Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated an...

journal_title：Antimicrobial agents and chemotherapy

authors： Tenney JH,Maack RW,Chippendale GR

更新日期：1983-01-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00

abstract：:The susceptibilities of a range of gram-positive and gram-negative microbial pathogens to clofazimine and its analog B669 (0.1 to 32 micrograms/ml), as well as the effects of these agents on membrane phospholipid metabolism in Staphylococcus aureus and Escherichia coli, have been investigated in vitro. Gram-positive b...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rensburg CE,Jooné GK,O'Sullivan JF,Anderson R

更新日期：1992-12-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:Olorofim is a novel antifungal drug in phase 2 trials. It has shown promising in vitro activity against various molds, except for Mucorales. Initially, we observed a broad range of EUCAST MICs for Aspergillus fumigatus Here, we explored the MIC variability in more detail and prospectively investigated the susceptibili...

journal_title：Antimicrobial agents and chemotherapy

authors： Astvad KMT,Jørgensen KM,Hare RK,Datcu R,Arendrup MC

更新日期：2020-12-16 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:Twelve healthy volunteers participated in this randomized crossover study to compare the concentrations and recovery levels of fleroxacin and pefloxacin in urine and to assess their bactericidal activities against 12 strains of urinary pathogens with different susceptibilities over a wide range of MICs. The volunteers...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber KG,Theuretzbacher U,Kinzig M,Savov O,Sörgel F

更新日期：1998-07-01 00:00:00

abstract：:The in vitro susceptibility of Brucella melitensis was examined vis-a-vis the clinical outcome in 75 patients with brucellosis. The initial MICs for Brucella isolates from patients who relapsed and from those who did not were similar. Furthermore, the MICs for isolates from patients whose infections relapsed were no d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza J,Bosch J,Gudiol F,Liñares J,Viladrich PF,Martín R

更新日期：1986-12-01 00:00:00

abstract：:Optimal doses for antituberculosis (anti-TB) drugs in children have yet to be established. In 2010, the World Health Organization (WHO) recommended revised dosages of the first-line anti-TB drugs for children. Pharmacokinetic (PK) studies that investigated the adequacy of the WHO revised dosages to date have yielded c...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Alsultan A,Kwara A,Antwi S,Enimil A,Ortsin A,Dompreh A,Yang H,Wiesner L,Peloquin CA

更新日期：2018-08-27 00:00:00

abstract：:We have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-...

journal_title：Antimicrobial agents and chemotherapy

authors： Uckun FM,Chelstrom LM,Tuel-Ahlgren L,Dibirdik I,Irvin JD,Langlie MC,Myers DE

更新日期：1998-02-01 00:00:00

abstract：:Despite the availability of new antifungal compounds, invasive aspergillosis carries high morbidity and mortality in hematopoietic stem cell transplant recipients. In vitro studies and animal models suggest that the adoptive transfer of natural killer (NK) cells might be a promising immunotherapeutic option in this se...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmidt S,Schubert R,Tramsen L,Lehrnbecher T

更新日期：2019-01-29 00:00:00

abstract：:The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the tre...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavaldà J,Torres C,Tenorio C,López P,Zaragoza M,Capdevila JA,Almirante B,Ruiz F,Borrell N,Gomis X,Pigrau C,Baquero F,Pahissa A

更新日期：1999-03-01 00:00:00

abstract：:PCR was used to amplify a 238-bp region from Helicobacter pylori which corresponded to the quinolone resistance-determining region in Escherichia coli. The gyrA gene of H. pylori was cloned and sequenced. An open reading frame of 2,478 nucleotides coded for a polypeptide of 826 amino acids with a calculated molecular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore RA,Beckthold B,Wong S,Kureishi A,Bryan LE

更新日期：1995-01-01 00:00:00

abstract：:The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Fu KP

更新日期：1978-04-01 00:00:00

abstract：:A potential strategy that can be used to combat the worldwide AIDS epidemic is the development of a vaginal microbicide that prevents the sexual transmission of human immunodeficiency virus type 1 (HIV-1). Certain CC chemokines, including RANTES, MIP-1alpha, and MIP-1beta, might facilitate the development of such micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Kish-Catalone TM,Lu W,Gallo RC,DeVico AL

更新日期：2006-04-01 00:00:00

abstract：:Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Reda A,Marchillo K,Van Hecker J,Craig WA,Andes D

更新日期：2014-10-01 00:00:00

abstract：:There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing sign...

journal_title：Antimicrobial agents and chemotherapy

authors： Todd DA,Parlet CP,Crosby HA,Malone CL,Heilmann KP,Horswill AR,Cech NB

更新日期：2017-07-25 00:00:00

abstract：:MICs, time-kills, and postantibiotic effects (PAEs) of ABT-773 (a new ketolide) and 10 other agents were determined against 226 pneumococci. Against 78 ermB- and 44 mefE-containing strains, ABT-773 MICs at which 50% of the isolates tested were inhibited (MIC(50)s) and MIC(90)s were 0.016 to 0.03 and 0.125 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Ednie LM,Hoellman DM,Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：2000-07-01 00:00:00

abstract：:The mycobacterial embCAB operon encodes arabinosyl transferases, putative targets of the antimycobacterial agent ethambutol (EMB). Mutations in embB lead to resistance to EMB in Mycobacterium tuberculosis. The basis for natural, intrinsic resistance to EMB in nontuberculous mycobacteria (NTM) is not known; neither is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alcaide F,Pfyffer GE,Telenti A

更新日期：1997-10-01 00:00:00

abstract：:We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spanjaard L,Vandenbroucke-Grauls CM

更新日期：2008-05-01 00:00:00

abstract：:Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli, the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin. We report here that this hypersusceptibility can be observed in TolC-deficient cells and is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrushenko ZM,Zhao H,Zgurskaya HI,Rybenkov VV

更新日期：2016-04-22 00:00:00

abstract：:This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

更新日期：2010-09-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010. The carbapenem resistance of this strain was attributed to the production of a novel metallo-β-lactamase (MBL), named SMB-1 (Serratia metallo-β-lactamase). SMB-1 possessed a zinc binding motif, H(Q)XHXDH (residu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wachino J,Yoshida H,Yamane K,Suzuki S,Matsui M,Yamagishi T,Tsutsui A,Konda T,Shibayama K,Arakawa Y

更新日期：2011-11-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to...

journal_title：Antimicrobial agents and chemotherapy

authors： Cooksey RC,Facklam RR,Thornsberry C

更新日期：1978-04-01 00:00:00

abstract：:The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a trans...

journal_title：Antimicrobial agents and chemotherapy

authors： Bortolaia V,Mander M,Jensen LB,Olsen JE,Guardabassi L

更新日期：2015-05-01 00:00:00

abstract：:Since November 1982 at the Sainte-Justine Hospital in Montreal, ampicillin and cefotaxime were used in association as initial treatment (greater than or equal to 48 h) for childhood bacterial meningitis. In this report is described the in vitro interaction of the new regimen in comparison with that of the previous amp...

journal_title：Antimicrobial agents and chemotherapy

authors： Lapointe JR,Lavallée C,Michaud A,Chicoine L,Joncas JH

更新日期：1986-04-01 00:00:00

abstract：:Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bei ZC,Li GF,Zhao JH,Zhang M,Ji XG,Wang JY

更新日期：2020-10-20 00:00:00