Role of embB in natural and acquired resistance to ethambutol in mycobacteria.

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to detect the prevalen...

journal_title：Antimicrobial agents and chemotherapy

authors： Saravolatz SN,Martin H,Pawlak J,Johnson LB,Saravolatz LD

更新日期：2014-06-01 00:00:00

abstract：:Pharmacodynamic parameters have become increasingly important for the determination of the optimal dosing schedules of antibiotics. In this study, the postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA SMEs), and the sub-MIC effects (SMEs) of roxithromycin, clarithromycin, and azithromycin on refere...

journal_title：Antimicrobial agents and chemotherapy

authors： Odenholt-Tornqvist I,Löwdin E,Cars O

更新日期：1995-01-01 00:00:00

abstract：:The emergence of resistant strains among common and rare Candida species necessitates continuous monitoring of the in vitro susceptibilities of those isolates. We therefore assessed the in vitro activities of micafungin against 1,099 molecularly identified isolates belonging to 5 common and 20 rare Candida species by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meletiadis J,Geertsen E,Curfs-Breuker I,Meis JF,Mouton JW

更新日期：2016-09-23 00:00:00

abstract：:A multidrug-resistant (MDR) Pseudomonas fulva strain was isolated in 2006 from a urine sample. The isolate harbored the blaIMP-1 gene, which was located in a chromosomal Tn402-like class 3 integron as a gene cassette array of aacA31-fosE-blaIMP-1 Two mutations in gyrA and one mutation in parC were detected in quinolon...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto M,Matsumura Y,Gomi R,Matsuda T,Nakano S,Nagao M,Tanaka M,Ichiyama S

更新日期：2018-07-27 00:00:00

abstract：:Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Stockbauer KE,Williams DL,Kreiswirth BN,Musser JM

更新日期：1996-04-01 00:00:00

abstract：:This study investigates the role of active efflux system MexXY in the emergence of aminoglycoside (AG) resistance among cystic fibrosis (CF) isolates of Pseudomonas aeruginosa. Three genotypically related susceptible and resistant (S/R) bacterial pairs and three other AG-resistant CF strains were compared to four non-...

journal_title：Antimicrobial agents and chemotherapy

authors： Vogne C,Aires JR,Bailly C,Hocquet D,Plésiat P

更新日期：2004-05-01 00:00:00

abstract：:The discovery of quorum-sensing (QS) systems regulating antibiotic resistance and virulence factors (VFs) has afforded a novel opportunity to prevent bacterial pathogenicity. Dietary molecules have been demonstrated to attenuate QS circuits of bacteria. But, to our knowledge, no study exploring the potential of colost...

journal_title：Antimicrobial agents and chemotherapy

authors： Srivastava A,Singh BN,Deepak D,Rawat AK,Singh BR

更新日期：2015-04-01 00:00:00

abstract：:Drug exposure or pharmacodynamic breakpoints refer to a magnitude of drug exposure which separates a population into groups with high and low probabilities of attaining a desired outcome. We used a pharmacodynamic model of disseminated candidiasis to define an in vivo drug exposure breakpoint for flucytosine (5FC) aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Hope WW,Warn PA,Sharp A,Howard S,Kasai M,Louie A,Walsh TJ,Drusano GL,Denning DW

更新日期：2006-11-01 00:00:00

abstract：:We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin an...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss BD,Weiss EC,Haggard WO,Evans RP,McLaren SG,Smeltzer MS

更新日期：2009-01-01 00:00:00

abstract：:The need for novel antibacterial strategies and the awareness of the importance of quorum sensing (QS) in bacterial infections have stimulated research aimed at identifying QS inhibitors (QSIs). However, clinical application of QSIs identified so far is still distant, likely due to their unsuitability for use in human...

journal_title：Antimicrobial agents and chemotherapy

authors： Imperi F,Massai F,Ramachandran Pillai C,Longo F,Zennaro E,Rampioni G,Visca P,Leoni L

更新日期：2013-02-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:The bla(TLA-1) gene encoding an extended-spectrum beta-lactamase was identified in 11 enterobacterial isolates from Mexico City, Mexico. This gene was located on different plasmids and plasmid types with different sizes and incompatibility groups. It was associated with a novel insertion sequence, ISCR20, encoding a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Berçot B,Poirel L,Silva-Sanchez J,Nordmann P

更新日期：2010-09-01 00:00:00

abstract：:Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin serotype A. This fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,McKenzie R,Fuchs EJ,Jurao RA,An AT,Ahene A,Tomic M,Hendrix CW,Zenilman JM

更新日期：2014-09-01 00:00:00

abstract：:Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U,Faye I

更新日期：2008-09-01 00:00:00

abstract：:This study evaluated the pulmonary disposition of eravacycline in 20 healthy adult volunteers receiving 1.0 mg of eravacycline/kg intravenously every 12 h for a total of seven doses over 4 days. Plasma samples were collected at 0, 1, 2, 4, 6, and 12 h on day 4, with each subject randomized to undergo a single bronchoa...

journal_title：Antimicrobial agents and chemotherapy

authors： Connors KP,Housman ST,Pope JS,Russomanno J,Salerno E,Shore E,Redican S,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Speer A,Shrestha TB,Bossmann SH,Basaraba RJ,Harber GJ,Michalek SM,Niederweis M,Kutsch O,Wolschendorf F

更新日期：2013-02-01 00:00:00

abstract：:We compared the kinetics of amphotericin B (AMB) lung accumulation and fungal clearance by liposomal amphotericin B (L-AMB) and amphotericin B lipid complex (ABLC) in a neutropenic murine model of invasive pulmonary mucormycosis (IPM). Immunosuppressed BALB/c mice were inoculated with 1 x 10(6) Rhizopus oryzae spores ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lewis RE,Albert ND,Liao G,Hou J,Prince RA,Kontoyiannis DP

更新日期：2010-03-01 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:The Candida albicans CDR1 and CDR2 genes code for highly homologous ATP-binding cassette (ABC) transporters which are overexpressed in azole-resistant clinical isolates and which confer resistance to multiple drugs by actively transporting their substrates out of the cells. These transporters are formed by two homolog...

journal_title：Antimicrobial agents and chemotherapy

authors： Gauthier C,Weber S,Alarco AM,Alqawi O,Daoud R,Georges E,Raymond M

更新日期：2003-05-01 00:00:00

abstract：:The majority of clinical isolates of Moraxella catarrhalis produce beta-lactamase. The role of this enzyme in the phenomenon of indirect pathogenicity, in which a true pathogen such as Streptococcus pneumoniae is protected from the action of certain beta-lactam antibiotics, is well recognized. By using a simple contin...

journal_title：Antimicrobial agents and chemotherapy

authors： Budhani RK,Struthers JK

更新日期：1998-10-01 00:00:00

abstract：:The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dromer F,Chevalier R,Sendid B,Improvisi L,Jouault T,Robert R,Mallet JM,Poulain D

更新日期：2002-12-01 00:00:00

abstract：:Penicillinase-producing Neisseria gonorrhoeae has increased in the Far East to the point that penicillin can no longer be recommended as the drug of choice, mandating a change to spectinomycin. As part of an ongoing surveillance of antibiotic susceptibilities, minimal inhibitory concentrations of penicillin, tetracycl...

journal_title：Antimicrobial agents and chemotherapy

authors： Piziak MV,Woodbury C,Berliner D,Takafuji E,Kirkpatrick J,Opal S,Tramont E

更新日期：1984-01-01 00:00:00

abstract：:Ex vivo assay systems provide a powerful approach to studying human malaria parasite biology and to testing antimalarials. For rodent malaria parasites, short-term in vitro culture and ex vivo antimalarial susceptibility assays are relatively cumbersome, relying on in vivo passage for synchronization, since ring-stage...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang ZW,Malleret B,Russell B,Rénia L,Claser C

更新日期：2016-10-21 00:00:00

abstract：:The multiple-dose pharmacokinetics and tolerance of temafloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy volunteers. Temafloxacin was found to be well tolerated when administered orally every 12 h for 7 days at doses of 100, 200, 300, 400, 600, and 800 mg. Steady-state maximum and minimum...

journal_title：Antimicrobial agents and chemotherapy

authors： Granneman GR,Carpentier P,Morrison PJ,Pernet AG

更新日期：1992-02-01 00:00:00

abstract：:Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient MRSA have been recently reported. This study investigated the bactericidal activity of dalbavancin, a novel, semisynthetic glycopepti...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabés D,Candiani G,Romanó G,Brunati C,Riva S,Cavaleri M

更新日期：2004-04-01 00:00:00

abstract：:To study the antimalarial action of chloroquine, normal mouse erythrocytes were used as surrogates for erythrocytoid bodies. These bodies form in the endosomes of intraerythrocytic malaria parasites as they feed on their host and consist of erythrocyte cytoplasm enclosed in a vestige of the erythrocyte membrane. In su...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitch CD,Russell NV

更新日期：2006-07-01 00:00:00

abstract：:TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms, including tetracycline-specific efflux and ribosomal protection. The mechanism of action of TP-434 was assessed using both cell-based and in vitro assays. In Escherichia coli cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Grossman TH,Starosta AL,Fyfe C,O'Brien W,Rothstein DM,Mikolajka A,Wilson DN,Sutcliffe JA

更新日期：2012-05-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00