Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model.

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Bush K,Jacoby GA

更新日期：2010-03-01 00:00:00

abstract：:AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

journal_title：Antimicrobial agents and chemotherapy

authors： Shetty BV,Kosa MB,Khalil DA,Webber S

更新日期：1996-01-01 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:In a previous study we have shown that cultured epithelial cell lines can be used to measure the transepithelial passage of antimicrobial agents across the intestine and to obtain information on the mechanisms of transport utilized and predict the bioavailability of the antimicrobial agents after oral administration. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranaldi G,Islam K,Sambuy Y

更新日期：1994-06-01 00:00:00

abstract：:Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence of mprF mutations and DAP-NS....

journal_title：Antimicrobial agents and chemotherapy

authors： Jenson RE,Baines SL,Howden BP,Mishra NN,Farah S,Lew C,Berti AD,Shukla SK,Bayer AS,Rose WE

更新日期：2020-08-20 00:00:00

abstract：:This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance in constitutively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Bacciaglia A,Vecchi M,Vitali LA,Varaldo PE,Giovanetti E

更新日期：2007-04-01 00:00:00

abstract：:A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employ...

journal_title：Antimicrobial agents and chemotherapy

authors： Upcroft JA,Upcroft P

更新日期：2001-06-01 00:00:00

abstract：:Placental drug transfer is important for achieving better pharmacotherapy in pregnant women and in fetuses. In the present study, we examined the effects of anti-hepatitis C virus (HCV) and anti-HIV drugs on organic anion transport in human placental BeWo cells. The cellular uptake of two fluorescence organic anions, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nabekura T,Kawasaki T,Kamiya Y,Uwai Y

更新日期：2015-12-01 00:00:00

abstract：:To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to that of praziquantel against both adult and juvenile Schistosoma ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Panic G,Ruf MT,Keiser J

更新日期：2017-11-22 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic with potent in vitro activity against gram-positive cocci, including Staphylococcus aureus. This study evaluated the in vitro and in vivo efficacies of daptomycin against two clinical isolates: methicillin-resistant S. aureus (MRSA) 277 (vancomycin MIC, 2 microg/ml) and glycopept...

journal_title：Antimicrobial agents and chemotherapy

authors： Marco F,de la Mària CG,Armero Y,Amat E,Soy D,Moreno A,del Río A,Almela M,Mestres CA,Gatell JM,Jiménez de Anta MT,Miró JM,Hospital Clinic Experimental Endocarditis Study Group.

更新日期：2008-07-01 00:00:00

abstract：:VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we evaluated a VT-1129 loading dose-maintenance dose strategy against cryptococcal meningitis. VT-1129 plasma and brain pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Xu X,Wang A,Najvar LK,Garvey EP,Ottinger EA,Alimardanov A,Cradock J,Behnke M,Hoekstra WJ,Brand SR,Schotzinger RJ,Jaramillo R,Olivo M,Kirkpatrick WR,Patterson TF

更新日期：2018-10-24 00:00:00

abstract：:MUC7 12-mer-L exhibits potent in vitro antifungal activity in low-ionic-strength buffers. In this study, we investigated the anticandidal activity and stability of MUC7 12-mer-L and its all-D-amino-acid isomer, along with Hsn5 12-mer (P113) and magainin-II, in human clarified and unclarified saliva in the absence or p...

journal_title：Antimicrobial agents and chemotherapy

authors： Wei GX,Bobek LA

更新日期：2005-06-01 00:00:00

abstract：:A strain of Escherichia coli containing TEM-1 and CTX-M-1 was tested in an in vitro pharmacokinetic model against ceftazidime with and without AM-112, a serine beta-lactamase inhibitor. Ceftazidime alone was less effective than ceftazidime plus AM-112, and a single dose was more effective than three fractionated doses...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowker KE,Noel AR,Walsh TR,Rogers CA,MacGowan AP

更新日期：2004-11-01 00:00:00

abstract：:Berberine sulfate is an alkaloid extracted from the roots and bark of various plants and possesses antibacterial, antifungal, and antiprotozoal activities. Most studies have focused on the bacteriostatic or bactericidal activities of this compound. In this study, we report that berberine sulfate is bacteriostatic for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun D,Courtney HS,Beachey EH

更新日期：1988-09-01 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:Francisella tularensis, a bacterium which causes tularemia in humans, is classified as a CDC category A bioterrorism agent. In this study, we demonstrate that celecoxib, an anti-inflammatory cyclooxygenase-2 inhibitor in clinical use, exhibits activity against a type A strain of F. tularensis (Schu S4), the live vacci...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiu HC,Yang J,Soni S,Kulp SK,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-07-01 00:00:00

abstract：:Cefoxitin resistance, but not resistance to clindamycin, erythromycin, lincomycin, or tetracycline, was transferred by a conjugation-like process from Bacteroides thetaiotaomicron UN101, a clinical isolate haboring four kinds of plasmids, to other Bacteroides species. Of a sample of 20 cefoxitin-resistant transconjuga...

journal_title：Antimicrobial agents and chemotherapy

authors： Rashtchian A,Dubes GR,Booth SJ

更新日期：1982-10-01 00:00:00

abstract：:Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide. This microbe's propensity to form biofilms allows it to persist and to survive on clinical abiotic surfaces for long periods. In fact, A. baumannii biofilm formation and its multidrug-resistant nature severely compromise ...

journal_title：Antimicrobial agents and chemotherapy

authors： Krishnamoorthy S,Shah BP,Lee HH,Martinez LR

更新日期：2015-10-12 00:00:00

abstract：:Placental transfer of the HIV protease inhibitor darunavir was investigated in 5 term human cotyledons perfused with darunavir (1,000 ng/ml) in the maternal to fetal direction. The mean (± the standard deviation [SD]) fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 30 to 90 min) was 15.0%±...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandelbrot L,Duro D,Belissa E,Peytavin G

更新日期：2014-09-01 00:00:00

abstract：:Group B beta-hemolytic streptococci (GB-BHS) frequently cause severe infection in newborns. Previous in vitro studies showed accelerated killing of GB-BHS by ampicillin plus gentamicin as compared with ampicillin alone. To extend the in vitro observations, mice were infected experimentally with GB-BHS and treated with...

journal_title：Antimicrobial agents and chemotherapy

authors： Deveikis A,Schauf V,Mizen M,Riff L

更新日期：1977-05-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:Thirty-nine patients with uncomplicated gonorrhea were randomized to receive single, oral 50-, 100-, or 200-mg doses of trovafloxacin (CP-99,219), a new quinolone antibiotic. All 31 evaluable patients were cured of infection. Trovafloxacin was well tolerated. The trovafloxacin MICs at which 50 and 90% of 36 Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hook EW 3rd,Pinson GB,Blalock CJ,Johnson RB

更新日期：1996-07-01 00:00:00

abstract：:Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

更新日期：2006-12-01 00:00:00

abstract：:9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Pica F,Palamara AT,Rossi A,De Marco A,Amici C,Santoro MG

更新日期：2000-01-01 00:00:00

abstract：:Plasmid-mediated mechanisms, comprising TEM hyperproduction, TEM derivative production, and OXA production, lead to amoxicillin-clavulanic acid resistance in enterobacteria. The ability of the single-strand conformation polymorphism (SSCP)-PCR method to differentiate the genes encoding inhibitor-resistant beta-lactama...

journal_title：Antimicrobial agents and chemotherapy

authors： Speldooren V,Heym B,Labia R,Nicolas-Chanoine MH

更新日期：1998-04-01 00:00:00

abstract：:To determine whether low concentrations of aminoglycosides in combination with penicillin could effectively kill enterococci in vitro, we tested penicillin (20 micrograms/ml) in combination with decreasing concentrations of either streptomycin (20, 10, 5, and 1 micrograms/ml) or gentamicin (5, 3, 1, and 0.5 micrograms...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto JY,Wilson WR,Wright AJ,Geraci JE,Washington JA 2nd

更新日期：1980-12-01 00:00:00

abstract：:Nonpregnant and pregnant guinea pigs in the last third of gestation were injected intramuscularly with 4 mg of gentamicin per kg, and drug concentrations in plasma were determined by radioimmunoassay at several intervals after injection. The maximum gentamicin concentration was lower in pregnant than in nonpregnant an...

journal_title：Antimicrobial agents and chemotherapy

authors： Lelievre-Pegorier M,Sakly R,Meulemans A,Merlet-Benichou C

更新日期：1985-10-01 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00