Drug-induced regulation of the MDR1 promoter in Candida albicans.

abstract：:Different mechanisms of erythromycin resistance predominate in group C and G streptococcus (GCS and GGS, respectively) isolates collected from 1992 to 1995 in Finland. Of the 21 erythromycin-resistant GCS and 32 erythromycin-resistant GGS isolates, 95% had the mefA or mefE drug efflux gene and 94% had the ermTR methyl...

journal_title：Antimicrobial agents and chemotherapy

authors： Kataja J,Seppälä H,Skurnik M,Sarkkinen H,Huovinen P

更新日期：1998-06-01 00:00:00

abstract：:Exposure to isoniazid induced the expression of several secreted proteins in Mycobacterium tuberculosis H37Rv. Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated...

journal_title：Antimicrobial agents and chemotherapy

authors： Garbe TR,Hibler NS,Deretic V

更新日期：1996-07-01 00:00:00

abstract：:Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Niece KL,Akers KS

更新日期：2015-09-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Hosmillo M,Emmott E,Lu J,Goodfellow I

更新日期：2018-04-26 00:00:00

abstract：:Although often dismissed as contaminants when isolated from blood cultures, Bacillus spp. are increasingly recognized as capable of causing serious systemic infections. As part of a clinical-microbiological study, 89 strains of Bacillus spp. isolated from clinical blood cultures between 1981 and 1985 had their species...

journal_title：Antimicrobial agents and chemotherapy

authors： Weber DJ,Saviteer SM,Rutala WA,Thomann CA

更新日期：1988-05-01 00:00:00

abstract：:Development of resistance to the antipseudomonal penicillins and cephalosporins mediated by hyperproduction of the chromosomal cephalosporinase AmpC is a major threat to the successful treatment of Pseudomonas aeruginosa infections. Although ampD inactivation has been previously found to lead to a partially derepresse...

journal_title：Antimicrobial agents and chemotherapy

authors： Juan C,Moyá B,Pérez JL,Oliver A

更新日期：2006-05-01 00:00:00

abstract：:Despite being genetically monomorphic, the limited genetic diversity within the Mycobacterium tuberculosis complex (MTBC) has practical consequences for molecular methods for drug susceptibility testing and for the use of current antibiotics and those in clinical trials. It renders some representatives of MTBC intrins...

journal_title：Antimicrobial agents and chemotherapy

authors： Köser CU,Feuerriegel S,Summers DK,Archer JA,Niemann S

更新日期：2012-12-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:Single-dose nevirapine (sd-NVP) and extended NVP prophylaxis are widely used in resource-constrained settings to prevent vertical HIV-1 transmission. We assessed the pharmacokinetics of sd-NVP in 62 HIV-1-positive pregnant Ugandan woman and their newborns who were receiving sd-NVP prophylaxis to prevent mother-to-chil...

journal_title：Antimicrobial agents and chemotherapy

authors： Frank M,von Kleist M,Kunz A,Harms G,Schütte C,Kloft C

更新日期：2011-12-01 00:00:00

abstract：:Daptomycin-nonsusceptible (DAP-NS) Staphylococcus aureus often exhibits gain-in-function mutations in the mprF gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant S. aureus (MRSA), may prevent the emergence of mprF mutations and DAP-NS....

journal_title：Antimicrobial agents and chemotherapy

authors： Jenson RE,Baines SL,Howden BP,Mishra NN,Farah S,Lew C,Berti AD,Shukla SK,Bayer AS,Rose WE

更新日期：2020-08-20 00:00:00

abstract：:Hematogenous Candida meningoencephalitis (HCME) is a serious infection in premature neonates. Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp., but its efficacy and optimal regimens for human neonates with HCME are not known. A well-validated rabbit model of HCME was used to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Warn PA,Livermore J,Howard S,Felton TW,Sharp A,Gregson L,Goodwin J,Petraitiene R,Petraitis V,Cohen-Wolkowiez M,Walsh TJ,Benjamin DK Jr,Hope WW

更新日期：2012-02-01 00:00:00

abstract：:Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

更新日期：1987-09-01 00:00:00

abstract：:Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

journal_title：Antimicrobial agents and chemotherapy

authors： El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

更新日期：2015-01-01 00:00:00

abstract：:The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected po...

journal_title：Antimicrobial agents and chemotherapy

authors： Cardenas J,Quinn EL,Rooker G,Bavinger J,Pohlod D

更新日期：1986-03-01 00:00:00

abstract：:The effect of rifampin on cutaneous hypersensitivity was studied in 11 tuberculous patients. A suppressive effect was noted in eight patients, five of whom developed a negative response to the strength of purified protein derivative to which they had been shown to be previously sensitive. In one instance complete aner...

journal_title：Antimicrobial agents and chemotherapy

authors： Mukerjee P,Schuldt S,Kasik JE

更新日期：1973-12-01 00:00:00

abstract：:We determined the nucleotide sequence of the blaOXA-3(pMG25) gene from Pseudomonas aeruginosa. The bla structural gene encoded a protein of 275 amino acids representing one monomer of 31,879 Da for the OXA-3 enzyme. Comparisons between the OXA-3 nucleotide and amino acid sequences and those of class A, B, C, and D bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanschagrin F,Couture F,Levesque RC

更新日期：1995-04-01 00:00:00

abstract：:In response to a published concern about the potency and quality of generic vancomycin products, the United States Food and Drug Administration investigated a small sampling of the vancomycin products available in North America with regard to purity, content, and potency. To facilitate identification of impurities, a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hadwiger ME,Sommers CD,Mans DJ,Patel V,Boyne MT 2nd

更新日期：2012-06-01 00:00:00

abstract：:PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

更新日期：2005-08-01 00:00:00

abstract：:PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae IK,Jang SJ,Kim J,Jeong SH,Cho B,Lee K

更新日期：2011-03-01 00:00:00

abstract：:ME1100 (arbekacin inhalation solution) is an inhaled aminoglycoside that is being developed to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were undertaken to evaluate ME1100 regimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhavnani SM,Hammel JP,Lakota EA,Safir MC,VanScoy BD,Nagira Y,Rubino CM,Sato N,Koresawa T,Kondo K,Ambrose PG

更新日期：2020-09-21 00:00:00

abstract：:Metronidazole (MDZ) and related 5-nitroimidazoles are the recommended drugs for treatment of trichomoniasis, a sexually transmitted disease caused by the protozoan parasite Trichomonas vaginalis. However, novel treatment options are needed, as recent reports have claimed resistance to these drugs in T. vaginalis isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Mallo N,Lamas J,Leiro JM

更新日期：2013-06-01 00:00:00

abstract：:Two hundred and fifty-seven ampicillin-resistant clinical isolates of Haemophilus influenzae were tested by disk diffusion and MIC determination for susceptibility to aztreonam, imipenem, and amoxycillin combined with clavulanate. The modal MICs and MICs for 50 and 90% of isolates of all three antimicrobial agents for...

journal_title：Antimicrobial agents and chemotherapy

authors： Powell M,Williams JD

更新日期：1987-12-01 00:00:00

abstract：:Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Beshir K,Sutherland CJ,Merinopoulos I,Durrani N,Leslie T,Rowland M,Hallett RL

更新日期：2010-09-01 00:00:00

abstract：:The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt, M. Holly, L. W. Slice, M. I. Sherman, D. D. Richman, M. J. Potash, a...

journal_title：Antimicrobial agents and chemotherapy

authors： Witvrouw M,Pauwels R,Vandamme AM,Schols D,Reymen D,Yamamoto N,Desmyter J,De Clercq E

更新日期：1992-12-01 00:00:00

abstract：:Viral infections are among the main causes of death worldwide, and we lack antivirals for the majority of viruses. Heparin-like sulfated or sulfonated compounds have been known for decades for their ability to prevent infection by heparan sulfate proteoglycan (HSPG)-dependent viruses but only in a reversible way. We h...

journal_title：Antimicrobial agents and chemotherapy

authors： Cagno V,Gasbarri M,Medaglia C,Gomes D,Clement S,Stellacci F,Tapparel C

更新日期：2020-11-17 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:The outer membrane of gram-negative cells excludes hydrophobic molecules and is responsible for the resistance of these cells to a number of dyes, detergents, and antibiotics. We describe a test for hydrophobic permeability in which a series of tetracyclines with various hydrophobicities are used. Normal Escherichia c...

journal_title：Antimicrobial agents and chemotherapy

authors： Leive L,Telesetsky S,Coleman WG Jr,Carr D

更新日期：1984-05-01 00:00:00

abstract：:This study compared nine susceptibility testing methods and 12 endpoints for anidulafungin, caspofungin, and micafungin with the same collection of blinded FKS hot spot mutant (n = 29) and wild-type isolates (n = 94). The susceptibility tests included EUCAST Edef 7.1, agar dilution, Etest, and disk diffusion with RPMI...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Garcia-Effron G,Lass-Flörl C,Lopez AG,Rodriguez-Tudela JL,Cuenca-Estrella M,Perlin DS

更新日期：2010-01-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00