Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit.

abstract：:The management of long-term central venous catheter (LTCVC) infections by multidrug-resistant (MDR) bacteria in cancer patient is a challenge. The objectives of this study were to analyze outcomes in cancer patients with LTCVC-associated infection, identify risks for unfavorable outcomes, and determine the impact of M...

journal_title：Antimicrobial agents and chemotherapy

authors： Freire MP,Pierrotti LC,Zerati AE,Benites L,da Motta-Leal Filho JM,Ibrahim KY,Araujo PH,Abdala E

更新日期：2018-08-27 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are resistant to most antibiotics, making CRE infections extremely difficult to treat with available agents. Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) are predominant carbapenemases in CRE in the United States. Nacubactam is a bridged diazabicyclooctane (DBO) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes MD,Taracila MA,Good CE,Bajaksouzian S,Rojas LJ,van Duin D,Kreiswirth BN,Jacobs MR,Haldimann A,Papp-Wallace KM,Bonomo RA

更新日期：2019-07-25 00:00:00

abstract：:Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to cip...

journal_title：Antimicrobial agents and chemotherapy

authors： Webber MA,Talukder A,Piddock LJ

更新日期：2005-10-01 00:00:00

abstract：:Potential alternatives, including linezolid, adjunctive rifampin, and moxifloxacin, were evaluated against vancomycin-tolerant (P9802-020) and vancomycin-susceptible clinical isolates of Streptococcus pneumoniae in an in vitro pharmacodynamic model. Vancomycin exhibited maximal killing of 2-log(10) CFU/ml against P980...

journal_title：Antimicrobial agents and chemotherapy

authors： Cha R,Rybak MJ

更新日期：2003-06-01 00:00:00

abstract：:Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated a...

journal_title：Antimicrobial agents and chemotherapy

authors： McKessar SJ,Berry AM,Bell JM,Turnidge JD,Paton JC

更新日期：2000-11-01 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patie...

journal_title：Antimicrobial agents and chemotherapy

authors： Ogwang S,Good CE,Okware B,Nsereko M,Jacobs MR,Boom WH,Bark CM

更新日期：2015-09-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluc...

journal_title：Antimicrobial agents and chemotherapy

authors： Chau AS,Chen G,McNicholas PM,Mann PA

更新日期：2006-11-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibilities of strains havin...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:For the present report, a novel complex class 1 integron, In60, was characterized. Part of this integron includes the bla(CTX-M-9) gene and its downstream nucleotide sequence, which shares 81% and 78% nucleotide identity with those of kluA-1 beta-lactamase and orf3 of K. ascorbata, respectively. Furthermore, a new ins...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabaté M,Navarro F,Miró E,Campoy S,Mirelis B,Barbé J,Prats G

更新日期：2002-08-01 00:00:00

abstract：:We assessed prophylactic or continuous therapy of isavuconazole, posaconazole, or voriconazole in treating pulmonary murine mucormycosis. In the prophylaxis studies, only isavuconazole treatment resulted in significantly improved survival and lowered tissue fungal burden of immunosuppressed mice infected with Rhizopus...

journal_title：Antimicrobial agents and chemotherapy

authors： Gebremariam T,Alkhazraji S,Baldin C,Kovanda L,Wiederhold NP,Ibrahim AS

更新日期：2017-04-24 00:00:00

abstract：:TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of this study was to determine the pharmacokinetics (PK) and pharmacodynamics (PD) of TBR-652 in HIV-1-infected, antiretroviral treatment-experienced, CCR5 antagonist-naïve patients. A double-blind, placebo-controlled, randomized,...

journal_title：Antimicrobial agents and chemotherapy

authors： Marier JF,Trinh M,Pheng LH,Palleja SM,Martin DE

更新日期：2011-06-01 00:00:00

abstract：:Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are copre...

journal_title：Antimicrobial agents and chemotherapy

authors： Desta Z,Soukhova NV,Flockhart DA

更新日期：2001-02-01 00:00:00

abstract：:The activity of gemifloxacin against Haemophilus influenzae and Moraxella catarrhalis was compared to those of 11 other agents. All quinolones were very active (MICs,

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Kelly LM,Hoellman DB,Ednie LM,Clark CL,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：2000-03-01 00:00:00

abstract：:We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel R,Uhl JR,Kohner P,Hopkins MK,Steckelberg JM,Kline B,Cockerill FR 3rd

更新日期：1998-01-01 00:00:00

abstract：:Zika virus (ZIKV), a flavivirus transmitted by mosquitoes, was an almost neglected pathogen until its introduction in the Americas in 2015 and its subsequent explosive spread throughout the continent, where it has infected millions of people. The virus has caused social and sanitary alarm, mainly due to its associatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Saiz JC,Martín-Acebes MA

更新日期：2017-05-24 00:00:00

abstract：:The in vitro susceptibilities of 22 penicillinase-producing and 32 non-penicillinase-producing strains of Neisseria gonorrhoeae to 13 antimicrobial agents, including the new semisynthetic penicillins and cephalosporins, are reported. Ceftriaxone, ceftazidime, and cefotaxime were the most active agents tested; none of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Coovadia YM,Ramsaroop U

更新日期：1984-11-01 00:00:00

abstract：:Eight unrelated clinical Acinetobacter baumannii isolates resistant to all commonly used antibiotics were subjected to three-dimensional checkerboard microtiter plate dilution and time-kill studies at one-fourth of their MICs of polymyxin B, imipenem, and rifampin. Synergy was demonstrated with combinations of polymyx...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon J,Urban C,Terzian C,Mariano N,Rahal JJ

更新日期：2004-03-01 00:00:00

abstract：:In 24 patients with hepatitic C virus (HCV) infection who participated in a randomized trial with alpha 2B interferon, HCV RNA analysis by the polymerase chain reaction with two separate primer sets was performed at weeks 0, 4, and 24 and during a follow-up period of 6 to 9 months. Prior to therapy all patients were H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kleter GE,Brouwer JT,Heijtink RA,Schalm SW,Quint WG

更新日期：1993-03-01 00:00:00

abstract：:In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang M,Jacoby GA,Mills DM,Hooper DC

更新日期：2009-02-01 00:00:00

abstract：:A series of twelve recently synthesized 6-substituted derivatives of 9-beta-d-ribofuranosylpurine 3',5'-cyclic phosphate (RPcMP) were evaluated for in vitro antiviral activity, using inhibition of viral cytopathogenic effect as the primary parameter for evaluation. Inhibition of the development of intra- and extracell...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidwell RW,Huffman JH,Allen LB,Meyer RB Jr,Shuman DA,Simon LN,Robins RK

更新日期：1974-06-01 00:00:00

abstract：:The in vitro activities of tedizolid and 10 antistaphylococcal agents were compared against 111 methicillin-resistant Staphylococcus aureus (MRSA) strains from 14 epidemiologically characterized groups. Tedizolid, tigecycline, and daptomycin were the most potent agents, with tedizolid 4-fold more potent than linezolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Goering RV

更新日期：2013-06-01 00:00:00

abstract：:Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Rourke A,Beyhan S,Choi Y,Morales P,Chan AP,Espinoza JL,Dupont CL,Meyer KJ,Spoering A,Lewis K,Nierman WC,Nelson KE

更新日期：2020-02-21 00:00:00

abstract：:The effect of tryptophan-N-formylated gramicidin (NFG) on the growth of Plasmodium berghei in mice was tested in three different experiments. NFG was shown to be capable of inhibiting the growth of the parasite in a dose-dependent way, although its action did not result in elimination of the parasite and was only temp...

journal_title：Antimicrobial agents and chemotherapy

authors： Otten-Kuipers MA,Franssen FF,Nieuwenhuijs H,Overdulve JP,Roelofsen B,Op den Kamp JA

更新日期：1997-08-01 00:00:00

abstract：:The MICs of pyrazinamide (PZA) were determined for Mycobacterium tuberculosis cultivated under different pH conditions in 7H12 liquid medium. Mycobacterial growth was monitored by the radiometric method (BACTEC system; Johnston Laboratories, Inc., Towson, Md.). We observed a predictable eightfold difference between th...

journal_title：Antimicrobial agents and chemotherapy

authors： Salfinger M,Heifets LB

更新日期：1988-07-01 00:00:00

abstract：:3-Deazauridine, a synthetic analogue of uridine and a potential antitumor agent, was found to possess antiviral activity against a number of ribonucleic acid-containing animal viruses in mammalian cell culture. Inhibition of virus-induced cytopathogenic effects by 3-deazauridine was observed in cells infected with rhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Shannon WM,Arnett G,Schabel FM Jr

更新日期：1972-09-01 00:00:00

abstract：:The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal subjects, pharmacokinetic data were calculated, using a two-compartment open body model. The mean distribution serum half...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroy A,Humbert G,Godin M,Fillastre JP

更新日期：1980-03-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00