Abstract:
:A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 was lower than that across the OM of C152. Mutants deficient in the 43-kDa OMP could be selected in vitro from strain C152 in the presence of cefoxitin. All beta-lactam-resistant strains were sensitive to imipenem.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Kar AK,Ghosh AS,Chauhan K,Ahamed J,Basu J,Chakrabarti P,Kundu Mdoi
10.1128/AAC.41.10.2302subject
Has Abstractpub_date
1997-10-01 00:00:00pages
2302-4issue
10eissn
0066-4804issn
1098-6596journal_volume
41pub_type
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