Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.


:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.


Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.




Has Abstract


2018-10-24 00:00:00












  • Tolerance of Haemophilus influenzae to beta-lactam antibiotics.

    abstract::Two hundred clinical isolates of Haemophilus influenzae were tested for tolerance (MBC/MIC greater than or equal to 32) to ampicillin and cefotaxime by broth dilution tests. Of 200 strains, 9 were tolerant to ampicillin, and 10 were tolerant to cefotaxime. Tolerant organisms were identified in both systemic and nonsys...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bergeron MG,Lavoie GY

    更新日期:1985-08-01 00:00:00

  • Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.

    abstract::The presence and genetic content of integrons were investigated for 37 epidemiologically unrelated multiple-drug-resistant strains of Salmonella enterica serotype Typhimurium from humans. All isolates were resistant to ampicillin, chloramphenicol, kanamycin, streptomycin, sulfonamides, and trimethoprim, as well as to ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tosini F,Visca P,Luzzi I,Dionisi AM,Pezzella C,Petrucca A,Carattoli A

    更新日期:1998-12-01 00:00:00

  • Azlocillin and mezlocillin: new ureido penicillins.

    abstract::The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 8...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fu KP,Neu HC

    更新日期:1978-06-01 00:00:00

  • Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis.

    abstract::The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

    更新日期:2005-12-01 00:00:00

  • Method of evaluating effects of antibiotics on bacterial biofilm.

    abstract::Antibiotics are generally not effective against organisms in exopolysaccharide biofilms. A simple method of studying the effect of antibiotics on bacteria in established biofilms is reported. Escherichia coli ATCC 25922 cells grown overnight at 37 degrees C on Mueller-Hinton agar were suspended in buffer and dispensed...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Prosser BL,Taylor D,Dix BA,Cleeland R

    更新日期:1987-10-01 00:00:00

  • Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.

    abstract::L-nucleoside analogs are a new class of antiviral and anticancer agents, several of which are currently used in the clinic. The phosphorylation of these agents to the triphosphate form is thought to be important for exertion of their pharmacological activities. 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methylur...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hu R,Li L,Degrève B,Dutschman GE,Lam W,Cheng YC

    更新日期:2005-05-01 00:00:00

  • Activity of DX-619 compared to other agents against viridans group streptococci, Streptococcus bovis, and Cardiobacterium hominis.

    abstract::Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

    更新日期:2006-12-01 00:00:00

  • In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms.

    abstract::The antibacterial activity of octenidine dihydrochloride (WIN 41464-2) against intact preformed in vitro plaques of four indigenous oral plaque-forming microorganisms, Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, and Actinomyces naeslundii, was studied. Both absolute (plaque bactericidal index) a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Slee AM,O'Connor JR

    更新日期:1983-03-01 00:00:00

  • Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia.

    abstract::Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

    更新日期:2020-12-16 00:00:00

  • Quinine uptake by human polymorphonuclear neutrophils.

    abstract::The antimalarial drug quinine has been shown to impair human polymorphonuclear leukocyte (PMN) functions. To gain insight into the mechanism of this phenomenon, we investigated quinine uptake by PMN with a fluorometric assay based on the fluorescence properties of this drug. After 30 min of incubation at 37 degrees C ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: el Benna J,Pasquier C,Labro MT

    更新日期:1991-07-01 00:00:00

  • Interactions between glycopeptides and beta-lactams against isogenic pairs of teicoplanin-susceptible and -resistant strains of Staphylococcus haemolyticus.

    abstract::Four isogenic derivatives with stably increased glycopeptide MICs (all become resistant to teicoplanin) were obtained from four glycopeptide-susceptible clinical isolates of Staphylococcus haemolyticus. All strains were extensively analyzed and compared for a number of distinctive features. In particular, the results ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vignaroli C,Biavasco F,Varaldo PE

    更新日期:2006-07-01 00:00:00

  • In vitro and in vivo antibacterial activities of OPC-20011, a novel parenteral broad-spectrum 2-oxaisocephem antibiotic.

    abstract::OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

    更新日期:1998-11-01 00:00:00

  • Impact of cotrimoxazole on carriage and antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae in HIV-infected children in Zambia.

    abstract::This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

    更新日期:2010-09-01 00:00:00

  • The Novel Phage-Derived Antimicrobial Agent HY-133 Is Active against Livestock-Associated Methicillin-Resistant Staphylococcus aureus.

    abstract::Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage end...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kaspar U,de Haro Sautto JA,Molinaro S,Peters G,Idelevich EA,Becker K

    更新日期:2018-06-26 00:00:00

  • Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae.

    abstract::Carbapenem-resistant Enterobacteriaceae (CRE) can be mechanistically classified into carbapenemase-producing Enterobacteriaceae (CPE) and non-carbapenemase-producing carbapenem nonsusceptible Enterobacteriaceae (NCPCRE). We sought to investigate the effect of antecedent carbapenem exposure as a risk factor for NCPCRE ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Marimuthu K,Ng OT,Cherng BPZ,Fong RKC,Pada SK,De PP,Ooi ST,Smitasin N,Thoon KC,Krishnan PU,Ang MLT,Chan DSG,Kwa ALH,Deepak RN,Chan YK,Chan YFZ,Huan X,Zaw Linn K,Tee NWS,Tan TY,Koh TH,Lin RTP,Hsu LY,Sengupta

    更新日期:2019-09-23 00:00:00

  • Piperaquine pharmacodynamics and parasite viability in a murine malaria model.

    abstract::Piperaquine (PQ) is an important partner drug in antimalarial combination treatments, but the long half-life of PQ raises concerns about drug resistance. Our aim was to investigate the extended antimalarial effect of PQ in a study of drug efficacy, reinoculation outcomes, and parasite viability after the administratio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Moore BR,Ilett KF,Page-Sharp M,Jago JD,Batty KT

    更新日期:2009-07-01 00:00:00

  • Pharmacokinetic study of praziquantel administered alone and in combination with cimetidine in a single-day therapeutic regimen.

    abstract::A brief therapeutic regimen of praziquantel, reduced to a single day, has been effective for treatment of neurocysticercosis. To study its pharmacokinetic characteristics, levels of praziquantel in plasma were determined for eight healthy volunteers after the administration of three oral doses of 25 mg/kg of body weig...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jung H,Medina R,Castro N,Corona T,Sotelo J

    更新日期:1997-06-01 00:00:00

  • Microcin E492 is an unmodified peptide related in structure to colicin V.

    abstract::The pore-forming microcin E492 was purified by solid-phase extraction and reversed-phase high-pressure liquid chromatography. Its molecular mass was 7,886 Da. The entire 84-amino-acid sequence was determined. There is no postranslational modification in the secreted microcin, and the sequence has homologies with the s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pons AM,Zorn N,Vignon D,Delalande F,Van Dorsselaer A,Cottenceau G

    更新日期:2002-01-01 00:00:00

  • Erythromycin resistance in Borrelia burgdorferi.

    abstract::Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposu...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Terekhova D,Sartakova ML,Wormser GP,Schwartz I,Cabello FC

    更新日期:2002-11-01 00:00:00

  • Accumulation of norfloxacin by Bacteroides fragilis.

    abstract::The accumulation of norfloxacin by Bacteroides fragilis NCTC 9343 was determined by the modified fluorescence method. The time required to achieve a steady-state concentration (SSC) after allowing B. fragilis to accumulate norfloxacin in an aerobic or an anaerobic environment was approximately 2 min; the SSC achieved ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ricci V,Piddock LJ

    更新日期:2000-09-01 00:00:00

  • Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.

    abstract::Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn pat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Mohr JF 3rd,Ostrosky-Zeichner L,Wainright DJ,Parks DH,Hollenbeck TC,Ericsson CD

    更新日期:2008-05-01 00:00:00

  • Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant.

    abstract::Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal model of HCV gene expres...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zhang H,Hanecak R,Brown-Driver V,Azad R,Conklin B,Fox MC,Anderson KP

    更新日期:1999-02-01 00:00:00

  • Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood.

    abstract::Acyclovir-resistant clinical isolates of herpes simplex virus type 1 (HSV-1) were analyzed in vitro for their susceptibilities to essential oils of ginger, thyme, hyssop, and sandalwood. All essential oils exhibited high levels of virucidal activity against acyclovir-sensitive strain KOS and acyclovir-resistant HSV-1 ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Schnitzler P,Koch C,Reichling J

    更新日期:2007-05-01 00:00:00

  • Isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae from urinary tract infections.

    abstract::The isolation of trimethoprim-resistant, sulfonamide-susceptible Enterobacteriaceae causing urinary tract infections is reported. The appearance of these strains followed the introduction of trimethoprim alone for use as treatment. Trimethoprim resistance was attributable to plasmids or transposons less frequently in ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Towner KJ,Smith MA,Cowlishaw WA

    更新日期:1983-04-01 00:00:00

  • Tilorone hydrochloride: an oral interferon-inducing agent.

    abstract::Tilorone hydrochloride characteristically induces an unusually delayed and prolonged interferon response not commonly associated with other synthetic inducers. Maximum circulating interferon levels of 8,000 to 10,000 units/ml were detected 12 hr postinoculation and persisted for up to 30 hr after administration of til...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Stringfellow DA,Glasgow LA

    更新日期:1972-08-01 00:00:00

  • Rapid Identification of New Delhi Metallo-β-Lactamase (NDM) Using Tryptic Peptides and LC-MS/MS.

    abstract::There is significant interest in the development of mass spectrometry (MS) methods for antimicrobial resistance protein detection, given the ability of these methods to confirm protein expression. In this work, we studied the performance of a liquid chromatography, tandem MS multiple-reaction monitoring (LC-MS/MS MRM)...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wang H,Strich JR,Drake SK,Chen Y,Youn JH,Rosenberg AZ,Gucek M,Dekker JP,Suffredini AF

    更新日期:2019-08-23 00:00:00

  • Plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella krefeld strains isolated in the United States.

    abstract::Two types of transmissible plasmids which encode resistance to trimethoprim-sulfamethoxazole were found among five animal isolates of Salmonella krefeld. This is the first report of plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella strains isolated in the United States. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mathewson JJ,Murray BE

    更新日期:1983-03-01 00:00:00

  • In vitro and in vivo evidence for amphotericin B as a P-glycoprotein substrate on the blood-brain barrier.

    abstract::Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain bar...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wu JQ,Shao K,Wang X,Wang RY,Cao YH,Yu YQ,Lou JN,Chen YQ,Zhao HZ,Zhang QQ,Weng XH,Jiang C,Zhu LP

    更新日期:2014-08-01 00:00:00

  • Practical preclinical model for assessing the potential for unconjugated hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors.

    abstract::A practical preclinical model for the hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors has been developed. Indinavir and atazanavir produced significant hyperbilirubinemia, whereas amprenavir, the negative control, was indistinguishable from the ritonavir booster dose. This model was use...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kempf DJ,Waring JF,Morfitt DC,Werner P,Ebert B,Mitten M,Nguyen B,Randolph JT,DeGoey DA,Klein LL,Marsh K

    更新日期:2006-02-01 00:00:00

  • Antigen specific for bacteria resistant to tetracycline.

    abstract::Antisera produced against envelope fractions of tetracycline-resistant Escherichia coli and supernatant fluid of disrupted cells of tetracycline-resistant Salmonella typhi were adsorbed with the corresponding fractions of susceptible cultures. With these sera, cross-reacting antigens were demonstrated in the following...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Boldur I,Sompolinsky D

    更新日期:1974-08-01 00:00:00