Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa.

Abstract:

:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.

authors

Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.

doi

10.1128/AAC.00374-18

subject

Has Abstract

pub_date

2018-10-24 00:00:00

issue

11

eissn

0066-4804

issn

1098-6596

pii

AAC.00374-18

journal_volume

62

pub_type

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