Abstract:
:Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low prevalence of piperaquine reduced susceptibility in Africa. Additionally, the few isolates with reduced susceptibility to piperaquine did not harbor amplification of the plasmepsin II gene.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Robert MG,Foguim Tsombeng F,Gendrot M,Mosnier J,Amalvict R,Benoit N,Torrentino-Madamet M,Pradines B,French National Reference Centre for Imported Malaria Study Group.doi
10.1128/AAC.00374-18subject
Has Abstractpub_date
2018-10-24 00:00:00issue
11eissn
0066-4804issn
1098-6596pii
AAC.00374-18journal_volume
62pub_type
杂志文章abstract::The in vitro activity of MDL 62,879, a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu, against a wide range of recent clinical isolates of common aerobic gram-positive and anaerobic organisms was determined. MDL 62,879 was highly active against staphylococci (MI...
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journal_title:Antimicrobial agents and chemotherapy
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journal_title:Antimicrobial agents and chemotherapy
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pub_type: 杂志文章,随机对照试验
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journal_title:Antimicrobial agents and chemotherapy
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