Plasmid-determined resistance to boron and chromium compounds in Pseudomonas aeruginosa.


:Plasmids determining resistance to arsenic, mercury, silver, and tellurium compounds in Escherichia coli and Pseudomonas aeruginosa were tested for resistance to 40 other metal compounds. Resistance to trivalent boron and hexavalent chromium compounds was a property of certain P. aeruginosa plasmids.


Summers AO,Jacoby GA




Has Abstract


1978-04-01 00:00:00












  • Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa.

    abstract::The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Okamoto K,Gotoh N,Nishino T

    更新日期:2002-08-01 00:00:00

  • Double-stranded ribonucleic acid from Mengo virus: production, characterization, and interferon-inducing and antiviral activities in comparison with polyriboinosinic-polyribocytidylic acid.

    abstract::Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

    更新日期:1973-05-01 00:00:00

  • Improved sodium hydroxide digestion method without homogenization for extraction of gentamicin from renal tissue.

    abstract::Recovery of gentamicin from renal cortical tissue (assayed by fluorescence polarization immunoassay) was highest (P less than 0.05) when using a sodium hydroxide (NaOH) digestion procedure without homogenization (90.0 +/- 5.4%), followed by homogenization with NaOH digestion (85.8 +/- 7.7%) and homogenization with tri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brown SA,Sugimoto K,Smith GG,Garry FB

    更新日期:1988-04-01 00:00:00

  • Comparison of anaerobic susceptibility results obtained by different methods.

    abstract::Susceptibility tests using 7 antimicrobial agents (carbenicillin, chloramphenicol, clindamycin, penicillin, cephalothin, metronidazole, and tetracycline) were run against 35 anaerobes including Bacteroides fragilis (17), other gram-negative bacilli (7), clostridia (5), peptococci (4), and eubacteria (2). Results in tr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rosenblatt JE,Murray PR,Sonnenwirth AC,Joyce JL

    更新日期:1979-03-01 00:00:00

  • Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals.

    abstract::The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

    更新日期:1976-10-01 00:00:00

  • Bactericidal action of dapsone against Mycobacterium leprae in mice.

    abstract::Dapsone (4,4'-diaminodiphenylsulfone), incorporated into the mouse chow in a concentration of 0.1 g/100 g of diet, was administered for 1 week to mice in which Mycobacterium leprae had multiplied to the level of 10(6) organisms/footpad. M. leprae were harvested from these and also from control mice, diluted serially, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Levy L

    更新日期:1976-04-01 00:00:00

  • Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis.

    abstract::Cryptosporidium parvum is an important cause of diarrhea in humans and calves and can persistently infect immunocompromised hosts. Presently, there are no consistently effective parasite-specific drugs for cryptosporidiosis. We hypothesized that neutralizing monoclonal antibodies (MAbs) targeting the apical complex an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Riggs MW,Schaefer DA,Kapil SJ,Barley-Maloney L,Perryman LE

    更新日期:2002-02-01 00:00:00

  • In vitro activity of gemifloxacin (SB 265805) against anaerobes.

    abstract::Gemifloxacin mesylate (SB 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the National Committee for Clinical Laboratory Standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) CFU/spot. Comparative antimicrobials tested i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Goldstein EJ,Citron DM,Warren Y,Tyrrell K,Merriam CV

    更新日期:1999-09-01 00:00:00

  • Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects.

    abstract::Vaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, do...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Griffith DC,Loutit JS,Morgan EE,Durso S,Dudley MN

    更新日期:2016-09-23 00:00:00

  • Contribution of beta-lactamases to beta-lactam susceptibilities of susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates.

    abstract::The beta-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. A...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Segura C,Salvadó M,Collado I,Chaves J,Coira A

    更新日期:1998-06-01 00:00:00

  • Effect of protein binding on drug penetration into blister fluid.

    abstract::The effect of protein binding on drug penetration into blister fluid was evaluated by using cefonicid, ceftizoxime, and cefotaxime. Drug concentrations in a chamber with a high surface area/volume ratio (i.e., paper disk) follow changes in serum more closely than do those in a chamber with a low surface area/volume ra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shyu WC,Quintiliani R,Nightingale CH,Dudley MN

    更新日期:1988-01-01 00:00:00

  • Pharmacokinetics-Pharmacodynamics of a Novel β-Lactamase Inhibitor, CB-618, in Combination with Meropenem in an In Vitro Infection Model.

    abstract::The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies carried out using ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: VanScoy BD,Trang M,McCauley J,Conde H,Bhavnani SM,Friedrich LV,Alexander DC,Ambrose PG

    更新日期:2016-06-20 00:00:00

  • Depression of adenosylmethionine content of Escherichia coli by thioglycerol.

    abstract::The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglyce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Javor GT

    更新日期:1983-12-01 00:00:00

  • Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods.

    abstract::Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericid...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Klepser ME,Banevicius MA,Quintiliani R,Nightingale CH

    更新日期:1996-08-01 00:00:00

  • Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance.

    abstract::The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains. The main mechanisms of azole resistance include alterations in the C. glabrata ERG11 gene (CgERG11), which encodes the azole target enzyme, ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sanguinetti M,Posteraro B,Fiori B,Ranno S,Torelli R,Fadda G

    更新日期:2005-02-01 00:00:00

  • Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae.

    abstract::In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

    更新日期:2005-08-01 00:00:00

  • Differences in the growth of Aspergillus fumigatus on cycloheximide media at three temperatures.

    abstract::Cycloheximide (up to 0.4 g/liter) was significantly more inhibitory to the growth of three isolates of Aspergillus fumigatus at 23 C than at 37 or 45 C. Preincubation of the media for 7 days at 45 C did not alter the inhibitory effect of the cycloheximide at 23 C. Neither mutation nor adaptation in the fungus seems to...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Berger CL,Merz WG,Silva-Hutner M

    更新日期:1973-10-01 00:00:00

  • Microbiological aetiology, epidemiology, and clinical profile of prosthetic joint infections: are current antibiotic prophylaxis guidelines effective?

    abstract::Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Peel TN,Cheng AC,Buising KL,Choong PF

    更新日期:2012-05-01 00:00:00

  • Oral absorption of ofloxacin administered together with aluminum.

    abstract::A clinical study was carried out to establish the influence of aluminum on the oral absorption of ofloxacin. Ten healthy volunteers were included in a crossover study based on a Latin square design. The treatments that all volunteers received were A, consisting of 400 mg of ofloxacin, and B, consisting of 400 mg of of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Sánchez Navarro A,Martínez Cabarga M,Dominguez-Gil Hurlé A

    更新日期:1994-10-01 00:00:00

  • Alterations of penicillin-binding proteins 1A, 2X, and 2B in Streptococcus pneumoniae isolates for which amoxicillin MICs are higher than penicillin MICs.

    abstract::Penicillin-binding proteins (PBPs) of 15 selected penicillin- and amoxicillin-resistant Streptococcus pneumoniae isolates (MICs of 2 to 8 and 8 to 16 microg/ml, respectively) were studied. In addition to typical changes in PBPs 1A and 2X, these strains had 10 unique changes in PBP 2B, including a (618)A-G substitution...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kosowska K,Jacobs MR,Bajaksouzian S,Koeth L,Appelbaum PC

    更新日期:2004-10-01 00:00:00

  • Molecular Epidemiology and Genome Dynamics of New Delhi Metallo-β-Lactamase-Producing Extraintestinal Pathogenic Escherichia coli Strains from India.

    abstract::The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from ext...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ranjan A,Shaik S,Mondal A,Nandanwar N,Hussain A,Semmler T,Kumar N,Tiwari SK,Jadhav S,Wieler LH,Ahmed N

    更新日期:2016-10-21 00:00:00

  • Aminoglycoside resistance in Mycobacterium kansasii, Mycobacterium avium-M. intracellulare, and Mycobacterium fortuitum: are aminoglycoside-modifying enzymes responsible?

    abstract::Aminoglycoside acetyltransferase was detected in Mycobacterium kansasii and M. fortuitum but not in M. avium-M. intracellulare when they were screened by a radioassay. Aminoglycoside phosphotransferase and nucleotidyltransferase activities were absent from all three species tested. Acetyltransferases from both M. kans...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ho II,Chan CY,Cheng AF

    更新日期:2000-01-01 00:00:00

  • A Staphylococcus xylosus isolate with a new mecC allotype.

    abstract::Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a cl...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Harrison EM,Paterson GK,Holden MT,Morgan FJ,Larsen AR,Petersen A,Leroy S,De Vliegher S,Perreten V,Fox LK,Lam TJ,Sampimon OC,Zadoks RN,Peacock SJ,Parkhill J,Holmes MA

    更新日期:2013-03-01 00:00:00

  • Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model.

    abstract::The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with dru...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Long L,Hager C,Ghannoum M

    更新日期:2016-03-25 00:00:00

  • Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D beta-lactamases.

    abstract::We determined the nucleotide sequence of the blaOXA-3(pMG25) gene from Pseudomonas aeruginosa. The bla structural gene encoded a protein of 275 amino acids representing one monomer of 31,879 Da for the OXA-3 enzyme. Comparisons between the OXA-3 nucleotide and amino acid sequences and those of class A, B, C, and D bet...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sanschagrin F,Couture F,Levesque RC

    更新日期:1995-04-01 00:00:00

  • 8-aminoquinolines effective against Pneumocystis carinii in vitro and in vivo.

    abstract::The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Queener SF,Bartlett MS,Nasr M,Smith JW

    更新日期:1993-10-01 00:00:00

  • Virulence factors of Escherichia coli isolates that produce CTX-M-type extended-spectrum beta-lactamases.

    abstract::This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum beta-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phy...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pitout JD,Laupland KB,Church DL,Menard ML,Johnson JR

    更新日期:2005-11-01 00:00:00

  • Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria.

    abstract::Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention tri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Polhemus ME,Remich S,Ogutu B,Waitumbi J,Lievens M,Ballou WR,Heppner DG Jr

    更新日期:2008-04-01 00:00:00

  • Synergy between cilofungin and amphotericin B in a murine model of candidiasis.

    abstract::The efficacies of cilofungin and amphotericin B separately and together in mice with disseminated candidiasis were studied. Male CD-1 mice (age, 5 weeks) were infected intravenously with 3 X 10(5) CFU of Candida albicans. At 4 days postinfection, intraperitoneal therapy was initiated and was continued for 14 days. The...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hanson LH,Perlman AM,Clemons KV,Stevens DA

    更新日期:1991-07-01 00:00:00

  • In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.

    abstract::LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

    更新日期:2010-12-01 00:00:00