Delavirdine in combination with zidovudine in treatment of human immunodeficiency virus type 1-infected patients: evaluation of efficacy and emergence of viral resistance in a randomized, comparative phase III trial. The M/3331/0013B Study Group.

abstract：:Here, we report the first detection of carbapenemase-producing Escherichia coli in Alaska and in wildlife in the United States. Wild bird (gull) feces sampled at three locations in Southcentral Alaska yielded isolates that harbored plasmid-encoded blaKPC-2 or chromosomally encoded blaOXA-48 and genes associated with a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ahlstrom CA,Ramey AM,Woksepp H,Bonnedahl J

更新日期：2019-07-25 00:00:00

abstract：:Exposure to isoniazid induced the expression of several secreted proteins in Mycobacterium tuberculosis H37Rv. Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated...

journal_title：Antimicrobial agents and chemotherapy

authors： Garbe TR,Hibler NS,Deretic V

更新日期：1996-07-01 00:00:00

abstract：:The pharmacokinetics of a single 1-g intravenous dose of mezlocillin were examined in six functionally anephric patients undergoing hemodialysis. Hemodialysis clearance calculated by plasma extraction ratios across the dialyzer membrane and by dialysis fluid agree well, averaging 26 and 32 ml/min. Dialyzer extraction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Janicke DM,Mangione A,Schultz RW,Jusko WJ

更新日期：1981-11-01 00:00:00

abstract：:Intravenous inoculation of a group A hemolytic streptococcus caused lethal infections in all of eight untreated monkeys. Intramuscular injections of clindamycin-2-phosphate in a daily dose of 25 mg/kg given in equal morning and afternoon doses for 10 days resulted in survival of all of eight monkeys. Similar results w...

journal_title：Antimicrobial agents and chemotherapy

authors： Carlisle HN,Saslaw S

更新日期：1972-06-01 00:00:00

abstract：:This phase 1, open-label, single-dose, parallel-group study evaluated the pharmacokinetics (PK) of isavuconazole after a single oral dose of the prodrug isavuconazonium sulfate in healthy nonelderly (age, 18 to 45 years) and elderly (age, ≥65 years) males and females. Overall, 48 subjects were enrolled in the study (n...

journal_title：Antimicrobial agents and chemotherapy

authors： Desai AV,Han D,Kowalski DL,Lademacher C,Pearlman H,Yamazaki T

更新日期：2019-05-24 00:00:00

abstract：:To evaluate the exposure-response relationships for efficacy and safety of voriconazole and anidulafungin in adult patients with invasive aspergillosis (IA), a population pharmacokinetic-pharmacodynamic (PK-PD) analysis was performed with data from a phase 3, prospective, double-blind, comparative study evaluating vor...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu P,Mould DR

更新日期：2014-08-01 00:00:00

abstract：:Plazomicin is a new FDA-approved aminoglycoside antibiotic for complicated urinary tract infections (cUTI). In the product labeling, trough-based therapeutic drug management (TDM) is recommended for cUTI patients with renal impairment to prevent elevated trough concentrations associated with serum creatinine increases...

journal_title：Antimicrobial agents and chemotherapy

authors： Asempa TE,Kuti JL,Seroogy JD,Komirenko AS,Nicolau DP

更新日期：2019-09-23 00:00:00

abstract：:The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

journal_title：Antimicrobial agents and chemotherapy

authors： Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-07-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:Antisera produced against envelope fractions of tetracycline-resistant Escherichia coli and supernatant fluid of disrupted cells of tetracycline-resistant Salmonella typhi were adsorbed with the corresponding fractions of susceptible cultures. With these sera, cross-reacting antigens were demonstrated in the following...

journal_title：Antimicrobial agents and chemotherapy

authors： Boldur I,Sompolinsky D

更新日期：1974-08-01 00:00:00

abstract：:With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

更新日期：2001-05-01 00:00:00

abstract：:To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and transport in comparison w...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams GC,Liu A,Knipp G,Sinko PJ

更新日期：2002-11-01 00:00:00

abstract：:Two multidrug-resistant (MDR) mcr-1-harboring Klebsiella pneumoniae isolates from patients with urinary tract infections and one MDR Klebsiella quasipneumoniae isolate from a patient with bloodstream infection were identified to carry tmexCD1-toprJ1 The addition of the efflux pump inhibitor reduced the tigecycline MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： He R,Yang Y,Wu Y,Zhong LL,Yang Y,Chen G,Qin M,Liang X,Ahmed MAEE,Lin M,Yan B,Xia Y,Dai M,Chen H,Tian GB

更新日期：2021-01-20 00:00:00

abstract：:Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with N. gonorrhoeae are...

journal_title：Antimicrobial agents and chemotherapy

authors： Dukers-Muijrers NH,van Liere GA,Wolffs PF,Den Heijer C,Werner MI,Hoebe CJ

更新日期：2015-01-01 00:00:00

abstract：:There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest...

journal_title：Antimicrobial agents and chemotherapy

authors： Abe F,Ueyama J,Kawasumi N,Nadai M,Hayashi T,Kato M,Ohnishi M,Saito H,Takeyama N,Hasegawa T

更新日期：2008-09-01 00:00:00

abstract：:Chronic wound infections are associated with biofilm formation, which in turn has been correlated with drug resistance. However, the mechanism by which bacteria form biofilms in clinical environments is not clearly understood. This study was designed to investigate the biofilm formation potency of Acinetobacter bauman...

journal_title：Antimicrobial agents and chemotherapy

authors： He X,Lu F,Yuan F,Jiang D,Zhao P,Zhu J,Cheng H,Cao J,Lu G

更新日期：2015-08-01 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:Past studies conducted in Australian and American families have demonstrated that alpha 2b interferon (IFN) is effective in preventing rhinovirus-associated illnesses in exposed family members. IFN had been used by intranasal application for 7 days after exposure (5 x 10(6) IU/day). We used the same approach but with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Monto AS,Schwartz SA,Albrecht JK

更新日期：1989-03-01 00:00:00

abstract：:The use of gentamicin to control contamination in a tissue culture system for the isolation of Chlamydia was investigated. Gentamicin, at concentrations up to 100 mug/ml, did not appear to inhibit the growth of stock chlamydial strains, as judged by assays for iodine-staining inclusions. When 343 cervical and urethral...

journal_title：Antimicrobial agents and chemotherapy

authors： Wentworth BB

更新日期：1973-06-01 00:00:00

abstract：:The organic salt triethyl-n-hexylammonium triethyl-n-hexylboride (N(2226)B(2226)) has biostatic effects against two gram-positive bacteria, Bacillus subtilis and Micrococcus luteus, and the yeast Candida albicans. Escherichia coli and chicken embryo fibroblasts grown in tissue culture are more refractory to this compo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosenthal KS,Storm DR,Ford WT

更新日期：1975-10-01 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:New tetracycline and streptomycin resistance genes, tet(44) and ant(6)-Ib, were identified in Campylobacter fetus subsp. fetus within a transferable pathogenicity island that is typically unique to Campylobacter fetus subsp. venerealis. The 640-amino-acid tetracycline resistance determinant, Tet 44, belongs to a class...

journal_title：Antimicrobial agents and chemotherapy

authors： Abril C,Brodard I,Perreten V

更新日期：2010-07-01 00:00:00

abstract：:Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

更新日期：2014-09-01 00:00:00

abstract：:The bioactivity of imipenem at 20 micrograms/ml in various agar and broth media which are commonly used in susceptibility test assays was measured at different storage temperatures over time. Imipenem was found to be more stable at 4 degrees C than at -20 degrees C and least stable in all media at 35 degrees C. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Baron EJ,Hindler JA

更新日期：1984-06-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown that 1843U89, even without polyglutamylation, is a potent folate-based inhibitor of purified malarial parasite thymidylat...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang L,Lee PC,White J,Rathod PK

更新日期：2000-04-01 00:00:00

abstract：:Bacteriophages have been used for more than a century for (unconventional) therapy of bacterial infections, for half a century as tools in genetic research, for 2 decades as tools for discovery of specific target-binding proteins, and for nearly a decade as tools for vaccination or as gene delivery vehicles. Here we p...

journal_title：Antimicrobial agents and chemotherapy

authors： Yacoby I,Shamis M,Bar H,Shabat D,Benhar I

更新日期：2006-06-01 00:00:00

abstract：:Loss of viability of toxin-treated cells of Saccharomyces cerevisiae SCF 1717 could be prevented in the period before they altered physiologically if cells were incubated in media with a suitable concentration of potassium (0.08 to 0.13 M) and hydrogen ions (pH 6.2 to 6.7). Incorporation of higher amounts of potassium...

journal_title：Antimicrobial agents and chemotherapy

authors： Middelbeek EJ,Crützen QH,Vogels GD

更新日期：1980-10-01 00:00:00

abstract：:Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Prunier AL,Malbruny B,Tandé D,Picard B,Leclercq R

更新日期：2002-09-01 00:00:00