Synergism between N-formimidoyl thienamycin and gentamicin or tobramycin against enterococci.

abstract：:Himastatin, a cyclohexadepsipeptide antibiotic, had in vivo antitumor activity against localized P388 leukemia and B16 melanoma but had no distal site antitumor activity. An in vitro Bacillus subtilis well-agar diffusion assay was employed to test the hypothesis that himastatin was enzymatically inactivated. The activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mamber SW,Brookshire KW,Dean BJ,Firestone RA,Leet JE,Matson JA,Forenza S

更新日期：1994-11-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:The basis of bactericidal versus bacteriostatic action of antibiotics and the mechanism of bacterial cell death are largely unknown. Related to this important issue is the essential invulnerability to killing of persisters: cells forming a small subpopulation largely responsible for the recalcitrance of biofilms to ch...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaldalu N,Mei R,Lewis K

更新日期：2004-03-01 00:00:00

abstract：:Mycobacteroides abscessus (Mab) is an opportunistic environmental pathogen that can cause chronic pulmonary disease in the setting of structural lung conditions such as bronchiectasis, COPD and cystic fibrosis. These infections are often incurable and associated with rapid lung function decline. Mab is naturally resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Story-Roller E,Galanis C,Lamichhane G

更新日期：2020-12-23 00:00:00

abstract：:Despite controversies associated with forms and value of antibiotic therapy for cystic fibrosis patients, antibiotherapy remains a cornerstone in the management of those patients. Locally administered liposome-encapsulated antibiotics may offer advantages over free antibiotics, including sustained concentration of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Beaulac C,Clément-Major S,Hawari J,Lagacé J

更新日期：1996-03-01 00:00:00

abstract：:The antimicrobial activities of trovafloxacin, moxifloxacin, sanfetrinem, quinupristin-dalfopristin, and 14 other antimicrobial agents against 218 Bacteroides fragilis group strains were determined. A group of 10 imipenem-resistant strains were also tested. Imipenem, meropenem, and sanfetrinem had the lowest MICs of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Gómez M,Palau ML,Sánchez A,Picazo JJ

更新日期：1999-09-01 00:00:00

abstract：:Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI...

journal_title：Antimicrobial agents and chemotherapy

authors： Gobert JM,Remington KM,Zhu YQ,North TW

更新日期：1994-04-01 00:00:00

abstract：:All cells need to protect themselves against the osmotic challenges of their environment by maintaining low permeability to ions across their cell membranes. This is a basic principle of cellular function, which is reflected in the interactions among ion transport and drug efflux genes that have arisen during cellular...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen BE

更新日期：2014-01-01 00:00:00

abstract：:Whole and fractionated latex of Asclepias syriaca was tested for antimicrobial or growth-promoting activity with 16 genera and species of bacteria. Latex and extracted fractions (distilled water, acetic acid, sodium bicarbonate, sulfuric acid, and ethyl ether) possessed no detectable antimicrobial activity. Comparison...

journal_title：Antimicrobial agents and chemotherapy

authors： McCay S,Mahlberg P

更新日期：1973-02-01 00:00:00

abstract：:Enterococci are intrinsically resistant to low levels of aminoglycosides. We previously selected in vitro and in vivo Enterococcus faecalis with intermediate-level resistance to gentamicin that did not abolish synergism with a cell-wall-active agent (E. Aslangul et al., Antimicrob. Agents Chemother. 49:4144-4148, 2005...

journal_title：Antimicrobial agents and chemotherapy

authors： Aslangul E,Massias L,Meulemans A,Chau F,Andremont A,Courvalin P,Fantin B,Ruimy R

更新日期：2006-11-01 00:00:00

abstract：:The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Micek ST,Welch EC,Khan J,Pervez M,Doherty JA,Reichley RM,Kollef MH

更新日期：2010-05-01 00:00:00

abstract：:In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of beta-lactamase genes and ftsI gene mutations. For all isolates, the minimal co...

journal_title：Antimicrobial agents and chemotherapy

authors： Kishii K,Chiba N,Morozumi M,Ono A,Ida T,Ubukata K

更新日期：2010-09-01 00:00:00

abstract：:Mycobacterium leprae synthesizes large quantities of a specific phthiocerol-containing phenolic glycolipid in vivo. We have shown earlier that viable M. leprae readily incorporates radiolabeled palmitic acid into phenolic glycolipid I when residing in cultured macrophages in vitro and that this process is inhibited by...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramasesh N,Krahenbuhl JL,Hastings RC

更新日期：1989-05-01 00:00:00

abstract：:The inactivation of virus-contaminated nonporous inanimate surfaces was investigated using adenovirus type 8, a common cause of epidemic keratoconjunctivitis. A 10-microl inoculum of adenovirus was placed onto each stainless steel disk (1-cm diameter), and the inoculum was allowed to air dry for 40 min. Twenty-one dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Rutala WA,Peacock JE,Gergen MF,Sobsey MD,Weber DJ

更新日期：2006-04-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV). Although the mechanism of action of RBV against HTNV is not understood, RBV is metabolized in human cells to both RBV-5'-monophosphate, which inhibits IMP dehydrogenase, resulting in a decrease in intra...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Chung DH,Chu YK,Jonsson CB,Parker WB

更新日期：2007-01-01 00:00:00

abstract：:Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

更新日期：1999-07-01 00:00:00

abstract：:Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa Single-step selection experiments using three recently described LpxC inhibitors (compounds 2, 3, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones AK,Caughlan RE,Woods AL,Uehara K,Xie L,Barnes SW,Walker JR,Thompson KV,Ranjitkar S,Lee PS,Dean CR

更新日期：2019-12-20 00:00:00

abstract：:We previously reported the development of a prototype antibiotic sensitivity assay to detect drug-resistant Mycobacterium tuberculosis using infection by mycobacteriophage to create a novel nucleic acid transcript, a surrogate marker of mycobacterial viability, detected by reverse transcriptase PCR (M. C. Mulvey et al...

journal_title：Antimicrobial agents and chemotherapy

authors： Mulvey MC,Lemmon M,Rotter S,Lees J,Einck L,Nacy CA

更新日期：2015-01-01 00:00:00

abstract：:The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

更新日期：1972-10-01 00:00:00

abstract：:A clinical study was carried out to establish the influence of aluminum on the oral absorption of ofloxacin. Ten healthy volunteers were included in a crossover study based on a Latin square design. The treatments that all volunteers received were A, consisting of 400 mg of ofloxacin, and B, consisting of 400 mg of of...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez Navarro A,Martínez Cabarga M,Dominguez-Gil Hurlé A

更新日期：1994-10-01 00:00:00

abstract：:The therapeutic effects produced by formulations of amoxicillin plus clavulanic acid (BRL 25 000A and BRL 25 000G) were compared with those of amoxicillin and clavulanic acid separately against a variety of infections produced by amoxicillin-susceptible and beta-lactamase-producing (amoxicillin-resistant) bacteria. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Boon RJ,Beale AS,Comber KR,Pierce CV,Sutherland R

更新日期：1982-09-01 00:00:00

abstract：:Cefazolin and cephalothin disk susceptibility and minimal inhibitory concentration determinations were conducted on 591 clinical isolates. Cefazolin demonstrated superior activity, as shown by lower minimal inhibitory concentrations, and a greater percentage of isolates inhibited in the disk susceptibility test. The c...

journal_title：Antimicrobial agents and chemotherapy

authors： Actor P,Guarini J,Uri J,Dickson J,Pauls JF,Weisbach JA

更新日期：1974-01-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy agains...

journal_title：Antimicrobial agents and chemotherapy

authors： Zarember KA,Cruz AR,Huang CY,Gallin JI

更新日期：2009-06-01 00:00:00

abstract：:Pseudomonas aeruginosa infections result in high morbidity and mortality rates for individuals with cystic fibrosis (CF), with premature death often occurring. These infections are complicated by the formation of biofilms in the sputum. Antibiotic therapy is stymied by antibiotic resistance of the biofilm matrix, maki...

journal_title：Antimicrobial agents and chemotherapy

authors： Klare W,Das T,Ibugo A,Buckle E,Manefield M,Manos J

更新日期：2016-07-22 00:00:00

abstract：:Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta-lactam antibiotics provides synergistic killing. We investigated the possibility that beta-lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： Kiri N,Archer G,Climo MW

更新日期：2002-06-01 00:00:00

abstract：:Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause RNA chain termination. Here, we expand our studies on β-d-2'-C-methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Ehteshami M,Tao S,Ozturk T,Zhou L,Cho JH,Zhang H,Amiralaei S,Shelton JR,Lu X,Khalil A,Domaoal RA,Stanton RA,Suesserman JE,Lin B,Lee SS,Amblard F,Whitaker T,Coats SJ,Schinazi RF

更新日期：2016-07-22 00:00:00

abstract：:The antibacterial activity of octenidine dihydrochloride (WIN 41464-2) against intact preformed in vitro plaques of four indigenous oral plaque-forming microorganisms, Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, and Actinomyces naeslundii, was studied. Both absolute (plaque bactericidal index) a...

journal_title：Antimicrobial agents and chemotherapy

authors： Slee AM,O'Connor JR

更新日期：1983-03-01 00:00:00