In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00

abstract：:Salmonella spp. are important food-borne pathogens that are demonstrating increasing antimicrobial resistance rates in isolates obtained from food animals and humans. In this study, 10 multidrug-resistant, cephalosporin-resistant Salmonella isolates from bovine, porcine, and human sources from a single geographic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Winokur PL,Brueggemann A,DeSalvo DL,Hoffmann L,Apley MD,Uhlenhopp EK,Pfaller MA,Doern GV

更新日期：2000-10-01 00:00:00

abstract：:The epidemiology of the two common erythromycin resistance methylase (erm) genes ermA and ermC was analyzed by Southern blotting in 428 erythromycin-resistant Staphylococcus aureus strains isolated from blood between 1959 and 1988 in Denmark. ermA and/or ermC was present in 98% of the erythromycin-resistant strains te...

journal_title：Antimicrobial agents and chemotherapy

authors： Westh H,Hougaard DM,Vuust J,Rosdahl VT

更新日期：1995-02-01 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:The effect of foscarnet against human immunodeficiency virus (HIV) was evaluated in nine HIV-infected individuals; six completed 28 days of induction therapy. The overall mean increase in CD4+ lymphocytes was 64 cells per mm3. The mean decline in the HIV antigen concentration was 108 pg/ml (P = 0.03), and suppression ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fletcher CV,Collier AC,Rhame FS,Bennett D,Para MF,Beatty CC,Jones CE,Balfour HH Jr

更新日期：1994-03-01 00:00:00

abstract：:Several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant Staphylococcus aureus MI339 and vancomycin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Zervosen A,Lu WP,Chen Z,White RE,Demuth TP Jr,Frère JM

更新日期：2004-03-01 00:00:00

abstract：:The MICs for 90% of the organisms tested (MIC90S) of 11 antibiotics against 24 clinical isolates of Actinobacillus actinomycetemcomitans were determined by the MIC 2000 system. The lowest MIC90S (16 micrograms/ml) were observed with ceftriaxone and rifampin. The next lowest MIC90S were found with cephapirin, tetracycl...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Shulman D,Shulman ST,Glogowski WG

更新日期：1986-01-01 00:00:00

abstract：:Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezo...

journal_title：Antimicrobial agents and chemotherapy

authors： Battaglini D,Motos A,Li Bassi G,Yang H,Pagliara F,Yang M,Aguilera Xiol E,Meli A,Bobi J,Frigola G,Senussi T,Idone F,Travierso C,Chiurazzi C,Fernandez-Barat L,Rigol M,Ramirez J,Pelosi P,Chiumello D,Antonelli M,Nicol

更新日期：2020-12-16 00:00:00

abstract：:The MICs and minimum bactericidal concentrations (MBCs) for the biocides benzalkonium chloride and chlorhexidine were determined against 1,602 clinical isolates of Staphylococcus aureus. Both compounds showed unimodal MIC and MBC distributions (2 and 4 or 8 mg/liter, respectively) with no apparent subpopulation with r...

journal_title：Antimicrobial agents and chemotherapy

authors： Furi L,Ciusa ML,Knight D,Di Lorenzo V,Tocci N,Cirasola D,Aragones L,Coelho JR,Freitas AT,Marchi E,Moce L,Visa P,Northwood JB,Viti C,Borghi E,Orefici G,BIOHYPO Consortium.,Morrissey I,Oggioni MR

更新日期：2013-08-01 00:00:00

abstract：:The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either a...

journal_title：Antimicrobial agents and chemotherapy

authors： Thauvin C,Lemeland JF,Humbert G,Fillastre JP

更新日期：1988-06-01 00:00:00

abstract：:A plant pathogenic actinomycete identified as Streptomyces lydicus was isolated from the deep-pitted scab lesions of potato tubers. This strain produces a new polypeptide antibiotic named chandramycin. The antibiotic was isolated from culture broth by extraction with organic solvents and purified by chromatography. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh SK,Gurusiddaiah S

更新日期：1984-09-01 00:00:00

abstract：:The tuberculosis (TB) drug discovery pipeline is fueled by compounds identified in whole-cell screens against the causative agent, Mycobacterium tuberculosis Phenotypic screening enables the selection of molecules that inhibit essential cellular functions in live, intact bacilli grown under a chosen in vitro condition...

journal_title：Antimicrobial agents and chemotherapy

authors： Naran K,Moosa A,Barry CE 3rd,Boshoff HI,Mizrahi V,Warner DF

更新日期：2016-10-21 00:00:00

abstract：:Tedizolid and linezolid in vitro activities against 3,032 Gram-positive pathogens collected in Asia-Pacific, Eastern European, and Latin American medical centers during 2014 were assessed. The isolates were tested for susceptibility by the current reference broth microdilution methods. Due to concern over the effect o...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

更新日期：2016-08-22 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii is a major source of nosocomial infections worldwide and is mainly associated with the acquisition of OXA-type carbapenemases and, to a lesser extent, metallo-β-lactamases (MBLs). In this study, 82 nonepidemiologically related Acinetobacter strains carrying different types ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Zboromyrska Y,Mosqueda N,Morosini MI,García-Fernández S,Roca I,Cantón R,Marco F,Vila J

更新日期：2014-12-01 00:00:00

abstract：:The novel 6-substituted acyclouridine derivatives 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT), 1-[(2-hydroxyethoxy)methyl]-6-(3-methylphenylthio)thymine (HEPT-M), 6-cyclohexylthio-1-[(2-hydroxyethoxy) methyl]thymine (HEPT-H), and 1-[(2-hydroxyethoxy)methyl]-6-phenylthio-2- thiothymine (HEPT-S) have proved t...

journal_title：Antimicrobial agents and chemotherapy

authors： Baba M,De Clercq E,Iida S,Tanaka H,Nitta I,Ubasawa M,Takashima H,Sekiya K,Umezu K,Nakashima H

更新日期：1990-12-01 00:00:00

abstract：:A disk bioassay for determining clindamycin serum levels is presented. This method is rapid (results available in 6.0 to 6.5 h), reliable, and simple to perform. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Liberman DF,Fitzgerald J,Robertson RG

更新日期：1974-05-01 00:00:00

abstract：:Population distributions and quality control data for strains of Pseudomonas aeruginosa tested for gentamicin susceptibility on six lots of Mueller-Hinton agar were analyzed. The lots of agar were used in three University of Washington hospitals from April 1975 through October 1977. The analyses indicated that the per...

journal_title：Antimicrobial agents and chemotherapy

authors： Pollock HM,Minshew BH,Kenny MA,Schoenknecht FD

更新日期：1978-09-01 00:00:00

abstract：:MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyd DB,Ott JL

更新日期：1986-05-01 00:00:00

abstract：:VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we evaluated a VT-1129 loading dose-maintenance dose strategy against cryptococcal meningitis. VT-1129 plasma and brain pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Xu X,Wang A,Najvar LK,Garvey EP,Ottinger EA,Alimardanov A,Cradock J,Behnke M,Hoekstra WJ,Brand SR,Schotzinger RJ,Jaramillo R,Olivo M,Kirkpatrick WR,Patterson TF

更新日期：2018-10-24 00:00:00

abstract：:Staphylococcus aureus bacteremia (SAB) causes high rates of morbidity and death. Several studies in academic health settings have demonstrated that consultations from infectious diseases specialists improve the quality of care and clinical outcomes for SAB. Few data that describe the impact in resource-limited setting...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Valcarlos E,Won R,Chang E,Schwartz J

更新日期：2016-09-23 00:00:00

abstract：:Surveillance of the circulating Mycobacterium tuberculosis complex (MTC) strains in a given locality is important for understanding tuberculosis (TB) epidemiology. We performed molecular epidemiological studies on sputum smear-positive isolates that were collected for anti-TB drug resistance surveillance to establish ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lukoye D,Katabazi FA,Musisi K,Kateete DP,Asiimwe BB,Okee M,Joloba ML,Cobelens FG

更新日期：2014-07-01 00:00:00

abstract：:A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dortet L,Bernabeu S,Gonzalez C,Naas T

更新日期：2017-07-25 00:00:00

abstract：:Resistance of influenza viruses to antiviral drugs can emerge following medication or may result from natural variation. Two classes of anti-influenza virus drugs targeting either the M2 protein (amantadine and rimantadine) or neuraminidase (NA; oseltamivir and zanamivir) are currently licensed. These drugs are expect...

journal_title：Antimicrobial agents and chemotherapy

authors： Deyde VM,Nguyen T,Bright RA,Balish A,Shu B,Lindstrom S,Klimov AI,Gubareva LV

更新日期：2009-03-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Jackowski J,Grant RB

更新日期：1986-05-01 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:The in vitro activity of PD 127,391, a dihalogenated quinolone, was compared with those of ofloxacin, ciprofloxacin, nalidixic acid, gentamicin, and cefuroxime against 525 recent isolates and well-characterized antimicrobial agent-resistant strains. The MICs of PD 127,391 against 90% of members of the family Enterobac...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Ashby JP,Andrews JM

更新日期：1988-08-01 00:00:00

abstract：:The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration (IC(50)) against intrace...

journal_title：Antimicrobial agents and chemotherapy

authors： Maes L,Vanden Berghe D,Germonprez N,Quirijnen L,Cos P,De Kimpe N,Van Puyvelde L

更新日期：2004-01-01 00:00:00

abstract：:Resistance to 5-fluorocytosine was studied in 137 independent Candida albicans clinical isolates. Seventy-eight isolates (57%) were susceptible; 51 isolates (37%) were partially resistant; 8 isolates (6%) were highly resistant. All partially resistant isolates gave rise to variants which were highly resistant. Some su...

journal_title：Antimicrobial agents and chemotherapy

authors： Defever KS,Whelan WL,Rogers AL,Beneke ES,Veselenak JM,Soll DR

更新日期：1982-11-01 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00