Rapid disk test for determining clindamycin serum levels.

abstract：:Amoxycillin was significantly more active than ampicillin in the treatment of intraperitoneal mouse infections when administered by oral and parenteral routes, although the causal bacteria were equally susceptible in vitro to the two penicillins. Amoxycillin produced higher antibiotic blood concentrations in mice than...

journal_title：Antimicrobial agents and chemotherapy

authors： Comber KR,Osborne CD,Sutherland R

更新日期：1975-02-01 00:00:00

abstract：:The pharmacodynamic properties of levofloxacin (an optically active isomer of ofloxacin), ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA 1199 and MRSA 494, respectively)...

journal_title：Antimicrobial agents and chemotherapy

authors： Kang SL,Rybak MJ,McGrath BJ,Kaatz GW,Seo SM

更新日期：1994-12-01 00:00:00

abstract：:In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 of herpes simplex virus type 1 (HSV-1). The antiviral activity of each analog on cytopathic effect...

journal_title：Antimicrobial agents and chemotherapy

authors： Shoji Y,Shimada J,Mizushima Y,Iwasawa A,Nakamura Y,Inouye K,Azuma T,Sakurai M,Nishimura T

更新日期：1996-07-01 00:00:00

abstract：:Delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of Gram-positive and Gram-negative bacteria. In this study, 200 Streptococcus pneumoniae (plus 30 levofloxacin-resistant isolates), 200 Haemophilus influenzae, and 100 Moraxella catarrhalis isolates selected primarily from the Un...

journal_title：Antimicrobial agents and chemotherapy

authors： Flamm RK,Rhomberg PR,Huband MD,Farrell DJ

更新日期：2016-09-23 00:00:00

abstract：:The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed ...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellos-Bourboulis EJ,Karnesis L,Galani I,Giamarellou H

更新日期：2002-12-01 00:00:00

abstract：:The most widely used drug for treatment of candidiasis is fluconazole (FCZ). Recently, a new derivative of 1,4-benzothiazine, compound FS5, was developed. FS5 had an appreciable protective effect against murine candidiasis. The present study was designed to dissect the antifungal mechanisms triggered by FS5 and to est...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitzurra L,Fringuelli R,Perito S,Schiaffella F,Barluzzi R,Bistoni F,Vecchiarelli A

更新日期：1999-09-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen and leading cause of health care-associated infections. Daily chlorhexidine gluconate (CHG) bathing of patients is generally regarded as an effective strategy to reduce the occurrence of health care-associated infections. It is likely that E. faecalis is frequently ex...

journal_title：Antimicrobial agents and chemotherapy

authors： Li FJ,Palmer KL

更新日期：2018-05-25 00:00:00

abstract：:We have evaluated the efficacy of posaconazole (PSC), voriconazole (VRC), and amphotericin B (AMB) in a murine model of systemic infection by Cryptococcus gattii using immunocompromised animals and three clinical strains of the fungus. AMB was the most effective drug in prolonging the survival of mice and also in redu...

journal_title：Antimicrobial agents and chemotherapy

authors： Calvo E,Pastor FJ,Rodríguez MM,Pujol I,Guarro J

更新日期：2010-10-01 00:00:00

abstract：:BO-1341, a new antipseudomonal semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefotaxime, and cefoperazone. The in vitro activity of BO-1341 was generally superior or comparable to the activities of the reference antibiotics against clinical...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Sanada M,Matsuda K,Hashizume T,Asahi Y,Ushijima R,Ohtake N,Tanaka N

更新日期：1989-09-01 00:00:00

abstract：:The two components of virginiamycin, virginiamycin M (VM) and virginiamycin S (VS), were used to explore the life cycle of symbiosis-dependent and -independent strains of Bdellovibrio bacteriovorus during multiplication in a two-membered system with either living or heat-inactivated Escherichia coli or in axenic cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Varon M,Cocito C,Seijffers J

更新日期：1976-01-01 00:00:00

abstract：:A new commercial low-density microarray which identifies common extended-spectrum β-lactamase plasmid-mediated cephalosporinase genes, as well as carbapenemase (bla(KPC) and bla(NDM)) genes, was evaluated. We tested 207 clinical and reference/collection isolates of the Enterobacteriaceae possessing different bla genes...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Hujer AM,Naas T,de Castro RR,Endimiani A,Nordmann P,Glupczynski Y,Bonomo RA

更新日期：2011-09-01 00:00:00

abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

更新日期：2018-04-26 00:00:00

abstract：:The multiple-dose pharmacokinetics of amoxicillin (AM [administered twice daily in a 25-mg/kg of body weight intravenous dose]) in 17 preterm infants (11 males; gestational age, 29 +/- 1.9 weeks; birth weight, 1,175 +/- 278 g) were evaluated on day 3 of life. Blood samples were collected from an arterial catheter at 0...

journal_title：Antimicrobial agents and chemotherapy

authors： Huisman-de Boer JJ,van den Anker JN,Vogel M,Goessens WH,Schoemaker RC,de Groot R

更新日期：1995-02-01 00:00:00

abstract：:The effects of free amphotericin B (as Fungizone) and amphotericin B (AMB) incorporated into liposomes on the proliferation of lymphocytes were determined. Freshly obtained guinea pig and rat antigen-specific lymphocytes were compared with rat T-lymphocyte cell lines cultured for a long period of time. Incorporation o...

journal_title：Antimicrobial agents and chemotherapy

authors： Boggs JM,Chang NH,Goundalkar A

更新日期：1991-05-01 00:00:00

abstract：:Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1 gene and the CDR gene family. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. To monitor MDR1 expression under s...

journal_title：Antimicrobial agents and chemotherapy

authors： Harry JB,Oliver BG,Song JL,Silver PM,Little JT,Choiniere J,White TC

更新日期：2005-07-01 00:00:00

abstract：:The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

更新日期：1984-10-01 00:00:00

abstract：:Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

journal_title：Antimicrobial agents and chemotherapy

authors： Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

更新日期：2013-09-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) involves combination treatment with three or more antiretroviral agents. The antiviral effects of combinations of emtricitabine (FTC) plus tenofovir (TFV) plus antiretroviral agents of all the major drug classes were investigated. Combinations of FTC and TFV with a nonnucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulkarni R,Hluhanich R,McColl DM,Miller MD,White KL

更新日期：2014-10-01 00:00:00

abstract：:One hundred clinical isolates of methicillin-resistant (Metr) Staphylococcus aureus from five different geographical origins were tested for their susceptibility to 12 non-beta-lactam antibiotics by the broth microdilution technique recommended by the National Committee for Clinical Laboratory Standards. Coumermycin a...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Janney A,Sanders CV

更新日期：1985-11-01 00:00:00

abstract：:The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson BC,Métifiot M,Pommier Y,Hughes SH

更新日期：2012-01-01 00:00:00

abstract：:Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rifkind D,Crowder ED,Hyland RN

更新日期：1974-12-01 00:00:00

abstract：:Treatment of Escherichia coli K-10 with 100 mug of chloramphenicol per ml for periods greater than 30 min leads to progressive lysis and killing of cells. The bactericidal action of the antibiotic is dependent on cell growth and physiology; only rapidly dividing cells are susceptible to killing; resting or slowly grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Guota RS

更新日期：1975-06-01 00:00:00

abstract：:Pseudomonas aeruginosa is equipped with the Sec and Tat protein secretion systems, which translocate the xenobiotic transporter MexAB-OprM and the pathogenic factor phospholipase C (PlcH), respectively. When the signal sequence of MexA was replaced with that of PlcH, the hybrid protein was successfully expressed and r...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoneyama H,Akiba K,Hori H,Ando T,Nakae T

更新日期：2010-04-01 00:00:00

abstract：:The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium avium complex isolated from patients with AIDS were evaluated in a model of intracellular infection and were compared with that of clarithromycin. Human monocyte-derived macrophages were infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne C,Gikas A,Truffot-Pernot C,Grosset J,Vilde JL,Pocidalo JJ

更新日期：1991-07-01 00:00:00

abstract：:Iron-sulfur flavoproteins (Isf) are flavin mononucleotide (FMN)- and FeS cluster-containing proteins commonly encountered in anaerobic prokaryotes. However, with the exception of Isf from Methanosarcina thermophila, which participates in oxidative stress management by removing oxygen and hydrogen peroxide, none of the...

journal_title：Antimicrobial agents and chemotherapy

authors： Smutná T,Pilarová K,Tarábek J,Tachezy J,Hrdý I

更新日期：2014-06-01 00:00:00

abstract：:Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resist...

journal_title：Antimicrobial agents and chemotherapy

authors： Theys K,Libin PJK,Van Laethem K,Abecasis AB

更新日期：2019-07-25 00:00:00

abstract：:The DNA sequences of two plasmids carrying vanA, pVEF1 (39,626 bp) and pVEF2 (39,714 bp), were determined. Forty-three shared coding sequences were identified, and the only nucleotide difference was an 88-bp indel. A postsegregational killing system was identified. This system possibly explains the persistence of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sletvold H,Johnsen PJ,Simonsen GS,Aasnaes B,Sundsfjord A,Nielsen KM

更新日期：2007-02-01 00:00:00

abstract：:Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hernandez V,Crépin T,Palencia A,Cusack S,Akama T,Baker SJ,Bu W,Feng L,Freund YR,Liu L,Meewan M,Mohan M,Mao W,Rock FL,Sexton H,Sheoran A,Zhang Y,Zhang YK,Zhou Y,Nieman JA,Anugula MR,Keramane el M,Savariraj K,

更新日期：2013-03-01 00:00:00

abstract：:Twenty-seven patients with advanced malignancies were given 200 mg of ketoconazole orally every 6 or 12 h. Blood samples were collected during these intervals and after the last dose to determine plasma concentrations and half-lives. The mean plasma concentrations measured after the initial dose were 1.7 +/- 1.1 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Maksymiuk AW,Levine HB,Bodey GP

更新日期：1982-07-01 00:00:00

abstract：:We investigated the relationship between susceptibility to beta-lactam antibiotics and variation in the major outer membrane protein P2 (OmpP2; also called porin) of persistent nonencapsulated Haemophilus influenzae isolated from cystic fibrosis patients. Nine OmpP2 variants were selected from two distinct H. influenz...

journal_title：Antimicrobial agents and chemotherapy

authors： Regelink AG,Dahan D,Möller LV,Coulton JW,Eijk P,Van Ulsen P,Dankert J,Van Alphen L

更新日期：1999-02-01 00:00:00