Activities of Nigerian chewing stick extracts against Bacteroides gingivalis and Bacteroides melaninogenicus.

abstract：:Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

更新日期：1973-05-01 00:00:00

abstract：:P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

journal_title：Antimicrobial agents and chemotherapy

authors： Nair S,Desai S,Poonacha N,Vipra A,Sharma U

更新日期：2016-11-21 00:00:00

abstract：:Pseudomonas aeruginosa colonizes the sputum of most adult cystic fibrosis patients, forming difficult-to-eradicate biofilms in which bacteria are protected in their self-produced extracellular polymeric substance (EPS) matrices. EPS provide biofilms with viscoelastic properties, causing time-dependent relaxation after...

journal_title：Antimicrobial agents and chemotherapy

authors： Rozenbaum RT,van der Mei HC,Woudstra W,de Jong ED,Busscher HJ,Sharma PK

更新日期：2019-03-27 00:00:00

abstract：:The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

更新日期：1989-08-01 00:00:00

abstract：:The pharmacokinetics of cefmenoxime were characterized in five healthy volunteers and in 15 subjects with various degrees of renal insufficiency after a single 10-mg/kg, 5-min intravenous infusion. Five of these subjects were studied both on hemodialysis and during an interdialytic period. Plasma, urine and dialysate ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gambertoglio JG,Alexander DP,Barriere SL

更新日期：1984-12-01 00:00:00

abstract：:Eighty adults in areas of Kenya where malaria is holoendemic received presumptive treatment with atovaquone-proguanil and were followed closely. The time to the first Plasmodium falciparum parasitemia was 32 days. This prolonged prophylaxis period has implications for study design when used in malaria intervention tri...

journal_title：Antimicrobial agents and chemotherapy

authors： Polhemus ME,Remich S,Ogutu B,Waitumbi J,Lievens M,Ballou WR,Heppner DG Jr

更新日期：2008-04-01 00:00:00

abstract：:We assessed the in vitro toxicity of tenofovir (TFV) and compared it with those of zidovudine (AZT), didanosine (ddI), ritonavir (RTV), and lopinavir (LPV) alone and in combination in human renal proximal tubule epithelial cells (RPTECs). The cells were treated with various concentrations and combinations of the teste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidal F,Domingo JC,Guallar J,Saumoy M,Cordobilla B,Sánchez de la Rosa R,Giralt M,Alvarez ML,López-Dupla M,Torres F,Villarroya F,Cihlar T,Domingo P

更新日期：2006-11-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:lacZ fusion strains were constructed using the promoters of five cell wall stress stimulon genes: pbp2, tcaA, vraSR, sgtB, and lytR. All fusion strains were induced only in the presence of cell wall-active antibiotics, suggesting the potential of these strains for use in high-throughput screening for new cell wall-act...

journal_title：Antimicrobial agents and chemotherapy

authors： Steidl R,Pearson S,Stephenson RE,Ledala N,Sitthisak S,Wilkinson BJ,Jayaswal RK

更新日期：2008-08-01 00:00:00

abstract：:Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic w...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryson D,Hettle AG,Boraston AB,Hobbs JK

更新日期：2020-02-21 00:00:00

abstract：:Against 198 viridans group streptococci, 25 Streptococcus bovis strains, and 5 Cardiobacterium hominis strains, MICs of DX-619, a des-F(6)-quinolone, were between 0.004 and 0.25 microg/ml. These MICs were lower than those of other quinolones (< or = 0.008 to > 32 microg/ml). Beta-lactam MICs were between < or = 0.008 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kosowska-Shick K,Smith K,Bogdanovich T,Ednie LM,Jones RN,Appelbaum PC

更新日期：2006-12-01 00:00:00

abstract：:The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and elect...

journal_title：Antimicrobial agents and chemotherapy

authors： Thorn RM,Robinson GM,Reynolds DM

更新日期：2013-05-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains have spread worldwide and become a major threat in health care facilities. Transmission of blaKPC, the plasmid-borne KPC gene, can be mediated by clonal spread and horizontal transfer. Here, we report the complete nucleotide sequences of two nov...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen L,Chavda KD,Melano RG,Hong T,Rojtman AD,Jacobs MR,Bonomo RA,Kreiswirth BN

更新日期：2014-01-01 00:00:00

abstract：:The 72 Escherichia coli strains of the ECOR collection were examined for resistance to 10 different antimicrobial agents including ampicillin, tetracycline, mercury, trimethoprim, and sulfonamides. Eighteen strains were resistant to at least one of the antibiotics tested, and nearly 20% (14 of 72) were resistant to tw...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazel D,Dychinco B,Webb VA,Davies J

更新日期：2000-06-01 00:00:00

abstract：:AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

journal_title：Antimicrobial agents and chemotherapy

authors： Shetty BV,Kosa MB,Khalil DA,Webber S

更新日期：1996-01-01 00:00:00

abstract：:BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more act...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakagawa S,Hashizume T,Matsuda K,Sanada M,Okamoto O,Fukatsu H,Tanaka N

更新日期：1993-12-01 00:00:00

abstract：:Clinical isolates of Gardnerella vaginalis, Streptococcus agalactiae, Bacteroides spp., and Mobiluncus spp. were screened for resistance to tetracycline and for the presence of the streptococcal tetM determinant. The S. agalactiae and G. vaginalis strains contained DNA sequences homologous to the tetM determinant, whi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts MC,Hillier SL,Hale J,Holmes KK,Kenny GE

更新日期：1986-11-01 00:00:00

abstract：:Cilofungin has potent in vitro activity against Candida albicans, but previous in vivo models using twice daily intermittent dosing regimens have not consistently demonstrated in vivo efficacy. Because of the pharmacokinetics of cilofungin in rabbits, it has been suggested that administration by continuous intravenous...

journal_title：Antimicrobial agents and chemotherapy

authors： Rouse MS,Tallan BM,Steckelberg JM,Henry NK,Wilson WR

更新日期：1992-01-01 00:00:00

abstract：:beta-L-2',3'-Dideoxy-5-fluorocytidine (beta-L-FddC), a novel cytidine analog with an unnatural beta-L sugar configuration, has been demonstrated by our group and others to exhibit highly selective in vitro activity against human immunodeficiency virus types 1 and 2 and hepatitis B virus. This encouraging in vitro anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Martin LT,Cretton-Scott E,Schinazi RF,Zhou XJ,McClure HM,Mathe C,Gosselin G,Imbach JL,Sommadossi JP

更新日期：1999-04-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one anoth...

journal_title：Antimicrobial agents and chemotherapy

authors： Stamm WE,Suchland R

更新日期：1986-11-01 00:00:00

abstract：:Dogs were experimentally inoculated with Rickettsia rickettsii to determine if anti-inflammatory or immunosuppressive dosages of prednisolone, when administered in conjunction with an antirickettsial antibiotic (doxycycline), induced therapeutically relevant pathophysiological consequences that ultimately influence di...

journal_title：Antimicrobial agents and chemotherapy

authors： Breitschwerdt EB,Davidson MG,Hegarty BC,Papich MG,Grindem CB

更新日期：1997-01-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters w...

journal_title：Antimicrobial agents and chemotherapy

authors： Keirns J,Sawamoto T,Holum M,Buell D,Wisemandle W,Alak A

更新日期：2007-02-01 00:00:00

abstract：:Candida albicans readily forms biofilms on the surface on indwelling medical devices, and these biofilms serve as a source of local and systemic infections. It is estimated that 27% of nosocomial C. albicans bloodstream infections are polymicrobial, with Staphylococcus aureus as the third most common organism isolated...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2009-09-01 00:00:00

abstract：:The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Ardanuy C,Tubau F,Liñares J,Domínguez MA,Pallarés R,Martín R,Spanish Pneumococcal Infection Study Network (G03\/103).

更新日期：2005-02-01 00:00:00

abstract：:The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitr...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Shea IP,Shahed M,Aguilera-Venegas B,Wilkinson SR

更新日期：2015-11-23 00:00:00

abstract：:ABT-492 is a novel quinolone with potent activity against gram-positive, gram-negative, and atypical pathogens, making this compound an ideal candidate for the treatment of community-acquired pneumonia. We therefore compared the in vitro pharmacodynamic activity of ABT-492 to that of levofloxacin, an antibiotic common...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson SM,Hayes RA,Quinn JP,Danziger LH

更新日期：2004-01-01 00:00:00