Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.

abstract：:The elimination kinetics of cefotetan (YM09330), a new parenteral semisynthetic cephamycin derivative, were studied in eight healthy volunteers and 41 patients with renal insufficiency after the administration of a single 500-mg dose intravenously. Concentrations of cefotetan in serum and urine were determined by both...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohkawa M,Hirano S,Tokunaga S,Motoi I,Shoda R,Ikeda A,Sugata T,Sawaki M,Shimamura M,Okasho A,Kuroda K

更新日期：1983-01-01 00:00:00

abstract：:Echinocandins are important in the prevention and treatment of invasive candidiasis but limited by current dosing regimens that include daily intravenous administration. The novel echinocandin CD101 has a prolonged half-life of approximately 130 h in humans, making it possible to design once-weekly dosing strategies. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,VanScoy B,Ambrose PG,Andes DR

更新日期：2018-01-25 00:00:00

abstract：:Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

journal_title：Antimicrobial agents and chemotherapy

authors： Schindler PR,Teuber M

更新日期：1975-07-01 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in b...

journal_title：Antimicrobial agents and chemotherapy

authors： Keith KE,Oyston PC,Crossett B,Fairweather NF,Titball RW,Walsh TR,Brown KA

更新日期：2005-04-01 00:00:00

abstract：:The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gordon RC,Regamey C,Kirby WM

更新日期：1972-09-01 00:00:00

abstract：:A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Schoenknecht FD,Shadomy S,Sherris JC,Thornsberry C,Washington JA,Kammer RB

更新日期：1979-01-01 00:00:00

abstract：:Shigella flexneri continues to be a major cause of diarrhea-associated illness, and increasing resistance to first-line antimicrobials complicates the treatment of infections caused by this pathogen. We investigated the pharmacodynamics of current antimicrobial treatments for shigellosis to determine the likelihood of...

journal_title：Antimicrobial agents and chemotherapy

authors： Allen GP,Harris KA

更新日期：2017-06-27 00:00:00

abstract：:Plasmid-mediated mechanisms, comprising TEM hyperproduction, TEM derivative production, and OXA production, lead to amoxicillin-clavulanic acid resistance in enterobacteria. The ability of the single-strand conformation polymorphism (SSCP)-PCR method to differentiate the genes encoding inhibitor-resistant beta-lactama...

journal_title：Antimicrobial agents and chemotherapy

authors： Speldooren V,Heym B,Labia R,Nicolas-Chanoine MH

更新日期：1998-04-01 00:00:00

abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

更新日期：2020-01-27 00:00:00

abstract：:Disk diffusion antibiotic susceptibility tests as performed by the hospital diagnostic microbiology laboratory were read at 4, 8, and 12 h of incubation and compared to the traditional 18-h readings. Both the zone size in millimeters and a judgement of susceptible or resistant were recorded by the investigator at each...

journal_title：Antimicrobial agents and chemotherapy

authors： Kluge RM

更新日期：1975-08-01 00:00:00

abstract：:New classes of antiparasitic drugs active against Trypanosoma brucei are needed to combat human African trypanosomiasis. Inhibitors of methionyl-tRNA synthetase (MetRS) have excellent potential to be developed for this purpose (S. Shibata, J. R. Gillespie, A. M. Kelley, A. J. Napuli, Z. Zhang, K. V. Kovzun, R. M. Pefl...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranade RM,Gillespie JR,Shibata S,Verlinde CL,Fan E,Hol WG,Buckner FS

更新日期：2013-07-01 00:00:00

abstract：:Antibiotic resistance of biofilm-grown bacteria contributes to chronic infections, such as marginal and periapical periodontitis, which are strongly associated with Porphyromonas gingivalis. Concurrent azithromycin (AZM) administration and mechanical debridement improve the clinical parameters of periodontal tissue in...

journal_title：Antimicrobial agents and chemotherapy

authors： Maezono H,Noiri Y,Asahi Y,Yamaguchi M,Yamamoto R,Izutani N,Azakami H,Ebisu S

更新日期：2011-12-01 00:00:00

abstract：:Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and a disk diffusion method. PCR was used to test drug-resistant genes, and the χ(2) test and definite probability methods were used to test for statistically significant differences among the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yin J,Yu S,Liu X,Li Y,Gao W,Ma X,Yang Y

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:Cyanovirin-N (CV-N), an 11-kDa protein originally isolated from the cyanobacterium Nostoc ellipsosporum, potently inactivates diverse strains of human immunodeficiency virus type 1 (HIV-1), HIV-2, simian immunodeficiency virus, and feline immunodeficiency virus. It has been well established that the HIV surface envelo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mori T,Boyd MR

更新日期：2001-03-01 00:00:00

abstract：:Ketoconazole, an oral antimycotic imidazole drug, blocked the transport of electrons in the respiratory chain of Candida albicans under aerobic conditions with different substrates, such as NADH and succinate. This effect was a nonspecific inhibition of NADH oxidases and succinate oxidases. The addition of ketoconazol...

journal_title：Antimicrobial agents and chemotherapy

authors： Shigematsu ML,Uno J,Arai T

更新日期：1982-06-01 00:00:00

abstract：:Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence share...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonnet R,Chanal C,Ageron E,Sirot D,De Champs C,Grimont P,Sirot J

更新日期：2002-10-01 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing e...

journal_title：Antimicrobial agents and chemotherapy

authors： Bebrone C,Bogaerts P,Delbrück H,Bennink S,Kupper MB,Rezende de Castro R,Glupczynski Y,Hoffmann KM

更新日期：2013-01-01 00:00:00

abstract：:While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry DR,Holmes DJ

更新日期：2008-03-01 00:00:00

abstract：:Several non-beta-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for methicillin-resistant Staphylococcus aureus MI339 and vancomycin-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Zervosen A,Lu WP,Chen Z,White RE,Demuth TP Jr,Frère JM

更新日期：2004-03-01 00:00:00

abstract：:Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the d...

journal_title：Antimicrobial agents and chemotherapy

authors： Bilal H,Bergen PJ,Tait JR,Wallis SC,Peleg AY,Roberts JA,Oliver A,Nation RL,Landersdorfer CB

更新日期：2020-06-23 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:The yeast Candida albicans is an opportunistic human fungal pathogen and the cause of superficial and systemic infections in immunocompromised patients. The classes of antifungal agents most commonly used to treat Candida infections are the azoles, polyenes, and echinocandins. In the present study, we identified chang...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoehamer CF,Cummings ED,Hilliard GM,Rogers PD

更新日期：2010-05-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans and Capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. They are resistant to many antibiotics of microbial origin but are sensitive to the n...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

更新日期：1993-12-01 00:00:00

abstract：:The resistance mechanisms of methicillin-resistant strains of Staphylococcus saprophyticus were characterized. Penicillin-binding protein (PBP) studies demonstrated an inducible PBP identical to PBP 2a in the membranes of these isolates. The amount of beta-lactamase produced was minimal. PBP 2a is responsible for the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Gelfand MS,Gerberding JL,Chambers HF

更新日期：1990-09-01 00:00:00

abstract：:Cephalosporins possessing a 1, 3-dithiolane, 1, 3-dithiane, or 1, 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii, Proteus rettgeri, and Proteus inconstans, which were not inhibited by clavulanic acid,...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohya S,Miyadera T,Yamazaki M

更新日期：1982-04-01 00:00:00

abstract：:Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c alpha Stx2, that h...

journal_title：Antimicrobial agents and chemotherapy

authors： Dowling TC,Chavaillaz PA,Young DG,Melton-Celsa A,O'Brien A,Thuning-Roberson C,Edelman R,Tacket CO

更新日期：2005-05-01 00:00:00

abstract：:This work reports, for the first time, the presence of New Delhi metallo-β-lactamase 1 (NDM-1) in Pseudomonas aeruginosa. Moreover, this is the first report of the NDM-1 presence in the Balkan region. Cosmid gene libraries of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical isolates MMA83 and MMA533 were scre...

journal_title：Antimicrobial agents and chemotherapy

authors： Jovcic B,Lepsanovic Z,Suljagic V,Rackov G,Begovic J,Topisirovic L,Kojic M

更新日期：2011-08-01 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00