Abstract:
:The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPC-producing, carbapenem-resistant Enterobacteriaceae.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Weiss WJ,Pulse ME,Nguyen P,Peterson K,Silva J,Simecka JW,Valtierra D,Sabet M,Griffith DCdoi
10.1128/AAC.01439-17subject
Has Abstractpub_date
2017-12-21 00:00:00issue
1eissn
0066-4804issn
1098-6596pii
AAC.01439-17journal_volume
62pub_type
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