Characterization of epidemic IncI1-Iγ plasmids harboring ambler class A and C genes in Escherichia coli and Salmonella enterica from animals and humans.

abstract：:A total of 100 and 97% of Haemophilus influenzae type b strains from major infections were susceptible, respectively, to levels of rifampin and sulfisoxazole attainable in saliva. It is theoretically feasible to eliminate Haemophilus influenzae from the nasopharynx with these drugs. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Cheung R

更新日期：1978-06-01 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conf...

journal_title：Antimicrobial agents and chemotherapy

authors： Cagliero C,Mouline C,Cloeckaert A,Payot S

更新日期：2006-11-01 00:00:00

abstract：:Because of the potential for an interaction between cephalosporins and aminoglycosides leading to renal injury, an evaluation of the effect of a new cephalosporin, cefamandole nafate, on the toxicity of the aminoglycoside tobramycin was performed in laboratory animals. High doses of cefamandole nafate did not increase...

journal_title：Antimicrobial agents and chemotherapy

authors： Wold JS,Turnipseed SA,Broddle WD,Owen NV

更新日期：1977-10-01 00:00:00

abstract：:Doxycycline is an alternative antibiotic drug for the treatment of syphilis, but data on its efficacy, especially data on its efficacy against late latent syphilis, are limited. A retrospective study was conducted to evaluate the effectiveness of doxycycline for the treatment of patients with different stages of syphi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dai T,Qu R,Liu J,Zhou P,Wang Q

更新日期：2016-12-27 00:00:00

abstract：:The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its penicillinase-negative derivative was investigated in vitro and in a rabbit experimental endocarditis model. Penicillin was sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Fantin B,Pierre J,Castéla-Papin N,Saint-Julien L,Drugeon H,Farinotti R,Carbon C

更新日期：1996-05-01 00:00:00

abstract：:In order to study the mechanism of insusceptibility of Spiroplasma citri to rifampin, we have cloned and sequenced its rpoB gene, which encodes the beta subunit of RNA polymerase. By comparison of the deduced amino acid sequence with sequences of beta subunits from susceptible and resistant bacteria, it was possible t...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaurivaud P,Laigret F,Bove JM

更新日期：1996-04-01 00:00:00

abstract：:Two group F vibrio organisms have been identified among a collection of vibrio strains isolated from the aquatic environment in Bangladesh. Neither group F strain produced a cholera-like enterotoxin. One of the isolates, BV12, contained an R plasmid conferring resistance to streptomycin and chloramphenicol. ...

journal_title：Antimicrobial agents and chemotherapy

authors： McNicol LA,Kaper JB,Lockman HA,Remmers EF,Spira WM,Colwell RR

更新日期：1980-03-01 00:00:00

abstract：:A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

journal_title：Antimicrobial agents and chemotherapy

authors： Ligozzi M,Rossolini GM,Tonin EA,Fontana R

更新日期：1991-03-01 00:00:00

abstract：:The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tylewska S,Hjertén S,Wadström T

更新日期：1981-11-01 00:00:00

abstract：:ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and ph...

journal_title：Antimicrobial agents and chemotherapy

authors： Jordan R,Chinsangaram J,Bolken TC,Tyavanagimatt SR,Tien D,Jones KF,Frimm A,Corrado ML,Pickens M,Landis P,Clarke J,Marbury TC,Hruby DE

更新日期：2010-06-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayden FG,Monto AS

更新日期：1986-02-01 00:00:00

abstract：:The antimicrobial efflux system encoded by the operon mef(E)-mel on the mobile genetic element MEGA in Streptococcus pneumoniae and other Gram-positive bacteria is inducible by macrolide antibiotics and antimicrobial peptides. Induction may affect the clinical response to the use of macrolides. We developed mef(E) rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Chancey ST,Zhou X,Zähner D,Stephens DS

更新日期：2011-07-01 00:00:00

abstract：:The pharmacokinetics and distribution in tissue of several novel triazole antifungal agents were studied in different animal species in order to select an appropriate lead compound. The purpose of the study was also to determine species differences in pharmacokinetics for SYN azoles to select the most appropriate spec...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan JK,Montaseri H,Poglod M,Bu HZ,Zuo Z,Salama SM,Daneshtalab M,Micetich RG

更新日期：2000-04-01 00:00:00

abstract：:Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hatfaludi T,Al-Hasani K,Dunstone M,Boyce J,Adler B

更新日期：2008-11-01 00:00:00

abstract：:We report retrospective analysis of the clinical and antimicrobial susceptibility data of 140 Streptococcus pseudopneumoniae isolates. Strains were isolated mostly from respiratory tract samples from patients with underlying diseases. In the case of infection, pneumonia, mainly aspiration pneumonia, was the most frequ...

journal_title：Antimicrobial agents and chemotherapy

authors： Laurens C,Michon AL,Marchandin H,Bayette J,Didelot MN,Jean-Pierre H

更新日期：2012-08-01 00:00:00

abstract：:Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([-]-beta-L-2',3'-dideoxy-3' thiacytidine) or famciclovir may select for viral mutants that are drug resistant due to point mutations in the polymerase gene. Determining whether such HBV mutants are sensitive to new antiviral agents is th...

journal_title：Antimicrobial agents and chemotherapy

authors： Chin R,Shaw T,Torresi J,Sozzi V,Trautwein C,Bock T,Manns M,Isom H,Furman P,Locarnini S

更新日期：2001-09-01 00:00:00

abstract：:The potential of bacteriophage therapy to treat infections caused by antibiotic-resistant bacteria has now been well established using various animal models. While numerous newly isolated bacteriophages have been claimed to be potential therapeutic candidates on the basis of in vitro observations, the parameters used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry M,Lavigne R,Debarbieux L

更新日期：2013-12-01 00:00:00

abstract：:Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis. MRSA was inoculated into the proximal tibia, and a titanium wire was implanted. Four weeks after infection...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergidis P,Rouse MS,Euba G,Karau MJ,Schmidt SM,Mandrekar JN,Steckelberg JM,Patel R

更新日期：2011-03-01 00:00:00

abstract：:Tafenoquine is a novel 8-aminoquinoline antimalarial drug recently approved by the U.S. Food and Drug Administration (FDA) for the radical cure of acute Plasmodium vivax malaria, which is the first new treatment in almost 60 years. A population pharmacokinetic (POP PK) analysis was conducted with tafenoquine exposure ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Green JA,Koh GCKW,Duparc S,Tenero D,Goyal N

更新日期：2018-10-24 00:00:00

abstract：:The majority of clinical isolates of Moraxella catarrhalis produce beta-lactamase. The role of this enzyme in the phenomenon of indirect pathogenicity, in which a true pathogen such as Streptococcus pneumoniae is protected from the action of certain beta-lactam antibiotics, is well recognized. By using a simple contin...

journal_title：Antimicrobial agents and chemotherapy

authors： Budhani RK,Struthers JK

更新日期：1998-10-01 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00

abstract：:The potent antiretroviral pyrimidinediones IQP-0528 (PYD1) and IQP-0532 (PYD2) were formulated in polyurethane intravaginal rings (IVRs) as prophylactic drug delivery systems to prevent the sexual transmission of HIV-1. To aid in the selection of a pyrimidinedione candidate and the optimal loading of the drug in the I...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson TJ,Srinivasan P,Albright TH,Watson-Buckheit K,Rabe L,Martin A,Pau CP,Hendry RM,Otten R,McNicholl J,Buckheit R Jr,Smith J,Kiser PF

更新日期：2012-03-01 00:00:00

abstract：:By means of a stepwise selection procedure, mutants capable of growing in the presence of relatively high multiplicities of a bacteriocin from Streptococcus mutans GS-5 were obtained from a sensitivie strain of Streptococcus pyogenes. Mutacin-neutralizing activity of cell extracts containing receptor protein was exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Franker CK

更新日期：1980-02-01 00:00:00

abstract：:The emergence of resistance to last-resort antibiotics is a public health concern of global scale. Besides direct person-to-person propagation, environmental pathways might contribute to the dissemination of antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Here, we describe the incidence of blaNDM...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantilla-Calderon D,Jumat MR,Wang T,Ganesan P,Al-Jassim N,Hong PY

更新日期：2016-08-22 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:The aims of this study were to describe the blood plasma (BP) and seminal plasma (SP) pharmacokinetics of tenofovir (TFV) in HIV-1-infected men, to assess the role of genetic polymorphism in the variability of TFV transfer into the male genital tract, and to evaluate the impact of TFV SP exposure on seminal plasma HIV...

journal_title：Antimicrobial agents and chemotherapy

authors： Valade E,Bouazza N,Lui G,Illamola SM,Benaboud S,Treluyer JM,Cobat A,Foissac F,De Sousa Mendes M,Chenevier-Gobeaux C,Suzan-Monti M,Rouzioux C,Assoumou L,Viard JP,Urien S,Ghosn J,Hirt D

更新日期：2017-02-23 00:00:00

abstract：:We determined the nucleotide sequence of a 6-kb DNA region harboring the recF, orf192, gyrB, and gyrA genes from Mycobacterium smegmatis mc(2)155. The amino acid sequences deduced from gyrA and gyrB displayed 89 and 86% identity, respectively, with the DNA gyrase from Mycobacterium tuberculosis, and 67 and 65% identit...

journal_title：Antimicrobial agents and chemotherapy

authors： Revel-Viravau V,Truong QC,Moreau N,Jarlier V,Sougakoff W

更新日期：1996-09-01 00:00:00

abstract：:Eight healthy male volunteers received 1 g of either ceftazidime or cefamandole as an intravenous infection. Serial blood samples were taken over the next 8 h. Urine samples were collected over 24 h. Levels of these antibiotics were measured in the fluid of blisters resulting from application of cantharides. The conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Armstrong GC,Wise R,Brown RM,Hancox J

更新日期：1981-09-01 00:00:00