Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance.

abstract：:The in vitro activities of tedizolid and 10 antistaphylococcal agents were compared against 111 methicillin-resistant Staphylococcus aureus (MRSA) strains from 14 epidemiologically characterized groups. Tedizolid, tigecycline, and daptomycin were the most potent agents, with tedizolid 4-fold more potent than linezolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Goering RV

更新日期：2013-06-01 00:00:00

abstract：:We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka R,Hanabusa H,Kinai E,Hasegawa N,Negishi M,Kato S

更新日期：2008-02-01 00:00:00

abstract：:To assess the potential for the induction of antimicrobial resistance following repeated subinhibitory exposures to the combination minocycline (MIN), rifampin (RIF), and chlorhexidine (CHX), a total of 29 clinical microbial pathogenic isolates were repeatedly exposed to subinhibitory concentrations of MIN, RIF, and C...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosenblatt J,Vargas-Cruz N,Reitzel RA,Raad II

更新日期：2019-04-25 00:00:00

abstract：:We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a type 2-preferential but not a type 2-specific antiviral effect. Utilizing a microtiter assay with BHK-21 cells, we found ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teh CZ,Sacks SL

更新日期：1983-05-01 00:00:00

abstract：:A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also de...

journal_title：Antimicrobial agents and chemotherapy

authors： Avanzi C,Maia RC,Benjak A,Nery JA,Sales AM,Miranda A,Duppre NC,Nogueira Brum Fontes A,Pereira da Silva T,Olmo Pinheiro R,Neves-Manta F,Moreira SJM,Busso P,Sarno EN,Suffys PN,Cole ST,Moraes MO

更新日期：2020-06-23 00:00:00

abstract：:We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant)...

journal_title：Antimicrobial agents and chemotherapy

authors： Donà V,Bernasconi OJ,Pires J,Collaud A,Overesch G,Ramette A,Perreten V,Endimiani A

更新日期：2017-10-24 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:Lupeol, which shows in vitro inhibitory activity against Plasmodium falciparum 3D7 strain with a 50% inhibitory concentration (IC50) of 27.7 +/- 0.5 microM, was shown to cause a transformation of the human erythrocyte shape toward that of stomatocytes. Good correlation between the IC50 value and the membrane curvature...

journal_title：Antimicrobial agents and chemotherapy

authors： Ziegler HL,Staerk D,Christensen J,Hviid L,Hägerstrand H,Jaroszewski JW

更新日期：2002-05-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:The absorption and excretion of equivalent doses of ampicillin, pivampicillin, and amoxycillin were compared in 10 healthy volunteers after administration of these antibiotics in a randomized triple crossover fashion. As recommended, ampicillin and amoxycillin were administered on an empty stomach, whereas pivampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L

更新日期：1974-11-01 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00

abstract：:The in vitro activities of extracts of Nigerian chewing sticks against Bacteroides gingivalis and B. melaninogenicus are presented. The greatest inhibitory action was produced by Serindeia werneckei, whereas Fagara zanthoxyloides produced no appreciable inhibitory effect. A generally good correlation was found between...

journal_title：Antimicrobial agents and chemotherapy

authors： Rotimi VO,Laughon BE,Bartlett JG,Mosadomi HA

更新日期：1988-04-01 00:00:00

abstract：:The effect of ethambutol (EMB) is primarily on polymerization steps in the biosynthesis of the arabinan component of cell wall arabinogalactan (AG) of Mycobacterium smegmatis. Inhibition of the synthesis of the arabinan of lipoarabinomannan (LAM) occurred later, and thus in the cases of AG and LAM, the polymerization ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikusová K,Slayden RA,Besra GS,Brennan PJ

更新日期：1995-11-01 00:00:00

abstract：:Cephradine, a semisynthetic cephalosporin, has widespread use. There is, however, a paucity of data on the transfer of this antibiotic in pregnancy. Studies were undertaken after an intravenous dose of 2 g of cephradine was given in two elective situations: (i) therapeutic abortion in the first trimester and (ii) elec...

journal_title：Antimicrobial agents and chemotherapy

authors： Craft I,Forster TC

更新日期：1978-12-01 00:00:00

abstract：:The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and beta-lactams, respectively (P < 0.01 for macrolides versus beta-lactams). We conclude ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Kofteridis DP,Manios A,Pediaditis J,Tselentis Y

更新日期：2001-12-01 00:00:00

abstract：:Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Beshir K,Sutherland CJ,Merinopoulos I,Durrani N,Leslie T,Rowland M,Hallett RL

更新日期：2010-09-01 00:00:00

abstract：:Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantim...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Lovelace JK,Waits VB,Hanson WL,Klayman DL

更新日期：1990-05-01 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:This randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (Augmentin XR) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment o...

journal_title：Antimicrobial agents and chemotherapy

authors： Sethi S,Breton J,Wynne B

更新日期：2005-01-01 00:00:00

abstract：:Acute otitis media, a polymicrobial disease of the middle ear cavity of children, is a significant public health problem worldwide. It is most frequently caused by encapsulated Streptococcus pneumoniae and nontypeable Haemophilus influenzae, although the widespread use of pneumococcal conjugate vaccines is apparently ...

journal_title：Antimicrobial agents and chemotherapy

authors： Domenech M,García E

更新日期：2017-01-24 00:00:00

abstract：:Azithromycin is an effective treatment for uncomplicated infections with Salmonella enterica serovar Typhi and serovar Paratyphi A (enteric fever), but there are no clinically validated MIC and disk zone size interpretative guidelines. We studied individual patient data from three randomized controlled trials (RCTs) o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parry CM,Thieu NT,Dolecek C,Karkey A,Gupta R,Turner P,Dance D,Maude RR,Ha V,Tran CN,Thi PL,Be BP,Phi LT,Ngoc RN,Ghose A,Dongol S,Campbell JI,Thanh DP,Thanh TH,Moore CE,Sona S,Gaind R,Deb M,Anh HV,Van SN,

更新日期：2015-05-01 00:00:00

abstract：:We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Guinea J,Recio S,Peláez T,Torres-Narbona M,Bouza E

更新日期：2008-09-01 00:00:00

abstract：:The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of li...

journal_title：Antimicrobial agents and chemotherapy

authors： Gikas A,Spyridaki I,Scoulica E,Psaroulaki A,Tselentis Y

更新日期：2001-11-01 00:00:00

abstract：:Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human mac...

journal_title：Antimicrobial agents and chemotherapy

authors： Clayette P,Martin M,Beringue V,Dereuddre-Bosquet N,Adjou KT,Seman M,Dormont D

更新日期：2000-02-01 00:00:00

abstract：:Halocidin is an antimicrobial peptide found in the tunicate. A series of experiments were previously conducted in an attempt to develop a novel antibiotic derived from halocidin, as the peptide was determined to evidence profound antimicrobial activity against a variety of antibiotic-resistant microbes, with significa...

journal_title：Antimicrobial agents and chemotherapy

authors： Jang WS,Lee SC,Lee YS,Shin YP,Shin KH,Sung BH,Kim BS,Lee SH,Lee IH

更新日期：2007-11-01 00:00:00

abstract：:Determination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocha PN,Macedo MN,Kobayashi CD,Moreno L,Guimarães LH,Machado PR,Badaró R,Carvalho EM,Glesby MJ

更新日期：2015-11-01 00:00:00

abstract：:Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium in mice. MICs of (+...

journal_title：Antimicrobial agents and chemotherapy

authors： Bermudez LE,Inderlied CB,Kolonoski P,Chee CB,Aralar P,Petrofsky M,Parman T,Green CE,Lewin AH,Ellis WY,Young LS

更新日期：2012-08-01 00:00:00

abstract：:The consequences of VanD type glycopeptide resistance on the activity of vancomycin and teicoplanin were evaluated in vitro and in a rabbit model of aortic endocarditis with VanD type clinical isolate Enterococcus faecium BM4339 (MICs: vancomycin, 64 microg/ml; teicoplanin, 4 microg/ml) and its susceptible derivative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lefort A,Garry L,Depardieu F,Courvalin P,Fantin B

更新日期：2003-11-01 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:Sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. They have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. This new family of compounds has also shown in vivo activity against murine Can...

journal_title：Antimicrobial agents and chemotherapy

authors： Aviles P,Pateman A,San Roman R,Guillén MJ,Gómez De Las Heras F,Gargallo-Viola D

更新日期：2001-10-01 00:00:00