Materno-fetal cephradine transfer in pregnancy.

abstract：:The present studies were conducted to better define the mechanism of action of polyethylene hexamethylene biguanide (PEHMB) (designated herein as NB325), which was shown in previous studies to inhibit infection by the human immunodeficiency virus type 1 (HIV-1). Fluorescence-activated flow cytometric analyses of activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Zhu W,Kholodovych V,Welsh W,Rando RF,Labib ME,Wigdahl B,Krebs FC

更新日期：2009-02-01 00:00:00

abstract：:7-[alpha-(1-Methyl-4-pyridiniothio)-acetamido] cephalosporanic acid, referred to herein as BL-S 217, is a new broad-spectrum semisynthetic cephalosporin that offers several advantages over cephalothin. A comparison of the activity in vitro of these antibiotics indicates that BL-S 217 is about eightfold more effective ...

journal_title：Antimicrobial agents and chemotherapy

authors： Buck RE,Leitner F,Price KE

更新日期：1972-01-01 00:00:00

abstract：:Sordarin and its derivatives are antifungal compounds of potential clinical interest. Despite the highly conserved nature of the fungal and mammalian protein synthesis machineries, sordarin is a selective inhibitor of protein synthesis in fungal organisms. In cells sensitive to sordarin, its mode of action is through ...

journal_title：Antimicrobial agents and chemotherapy

authors： Botet J,Rodríguez-Mateos M,Ballesta JP,Revuelta JL,Remacha M

更新日期：2008-05-01 00:00:00

abstract：:We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee DG,Chun HS,Yim DS,Choi SM,Choi JH,Yoo JH,Shin WS,Kang MW

更新日期：2003-12-01 00:00:00

abstract：:The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in t...

journal_title：Antimicrobial agents and chemotherapy

authors： Paul AS,Moreira CK,Elsworth B,Allred DR,Duraisingh MT

更新日期：2016-07-22 00:00:00

abstract：:We describe the clinical outcome of 17 patients with secondary Acinetobacter bacteremia whose isolates had a tigecycline MIC of ≤2 mg/liter and who received tigecycline within 2 days of bacteremia onset. The 14-day mortality rate of the tigecycline cohort was 41.2% (7/17), which was significantly higher than that of t...

journal_title：Antimicrobial agents and chemotherapy

authors： Liou BH,Lee YT,Kuo SC,Liu PY,Fung CP

更新日期：2015-01-01 00:00:00

abstract：:Seventy-five strains of Haemophilus influenzae type b, including 45 beta-lactamase-positive strains, were tested by MIC and time kill studies for susceptibility to ampicillin-sulbactam at various ratios. beta-Lactamase-negative strains were inhibited by lower concentrations of ampicillin-sulbactam than beta-lactamase-...

journal_title：Antimicrobial agents and chemotherapy

authors： Azimi PH,Dunphy MG

更新日期：1989-09-01 00:00:00

abstract：:Transferability of drug resistance in strains of Bordetella bronchiseptica isolated from pigs was examined. These strains were resistant to sulfadimethoxine (SA, more than 1,600 mug/ml), streptomycin (SM, more than 800 mug/ml), and aminobenzyl penicillin (APC, 200 mug/ml). All of them could transfer their drug resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Terakado N,Azechi H,Ninomiya K,Shimizu T

更新日期：1973-05-01 00:00:00

abstract：:Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were dete...

journal_title：Antimicrobial agents and chemotherapy

authors： Dabbs ER,Yazawa K,Mikami Y,Miyaji M,Morisaki N,Iwasaki S,Furihata K

更新日期：1995-04-01 00:00:00

abstract：:The rapid infusion of hyperosmolar solutions into the internal carotid artery transiently disrupts the integrity of the blood-brain barrier, permitting entry of substances normally excluded from the nervous system. This study examined the effect of such an infusion on the penetration of vancomycin and tobramycin into ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perkins BA,Strausbaugh LJ

更新日期：1983-09-01 00:00:00

abstract：:Antimicrobial liquids and foams were applied to the hands to determine their virucidal activity against rhinoviruses. Dilute solutions (1%) of iodine in ethyl alcohol or in water were most effective in causing inactivation of rhinovirus when applied immediately after viral contamination. Iodine also had a residual vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Hendley JO,Mika LA,Gwaltney JM Jr

更新日期：1978-11-01 00:00:00

abstract：:Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis wer...

journal_title：Antimicrobial agents and chemotherapy

authors： Sáez-Llorens X,Macias M,Maiya P,Pineros J,Jafri HS,Chatterjee A,Ruiz G,Raghavan J,Bradshaw SK,Kartsonis NA,Sun P,Strohmaier KM,Fallon M,Bi S,Stone JA,Chow JW

更新日期：2009-03-01 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basic cellular processes of relevance to pathogenic mycobacteria. This study focused on the D-alanine racemase gene (alrA), which is involved in the synthesis of D-alanine, a basic component of peptidoglycan that forms the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chacon O,Feng Z,Harris NB,Cáceres NE,Adams LG,Barletta RG

更新日期：2002-01-01 00:00:00

abstract：:Although often dismissed as contaminants when isolated from blood cultures, Bacillus spp. are increasingly recognized as capable of causing serious systemic infections. As part of a clinical-microbiological study, 89 strains of Bacillus spp. isolated from clinical blood cultures between 1981 and 1985 had their species...

journal_title：Antimicrobial agents and chemotherapy

authors： Weber DJ,Saviteer SM,Rutala WA,Thomann CA

更新日期：1988-05-01 00:00:00

abstract：:The efficacy and safety of a novel once-daily extended-release ciprofloxacin (ciprofloxacin ER) 500-mg dose were compared with those of an immediate-release ciprofloxacin (ciprofloxacin IR) 250-mg twice-daily dose, each administered orally for 3 days in the treatment of acute uncomplicated urinary tract infection (uUT...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourcroy JL,Berner B,Chiang YK,Cramer M,Rowe L,Shore N

更新日期：2005-10-01 00:00:00

abstract：:Placental drug transfer is important for achieving better pharmacotherapy in pregnant women and in fetuses. In the present study, we examined the effects of anti-hepatitis C virus (HCV) and anti-HIV drugs on organic anion transport in human placental BeWo cells. The cellular uptake of two fluorescence organic anions, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nabekura T,Kawasaki T,Kamiya Y,Uwai Y

更新日期：2015-12-01 00:00:00

abstract：:Three procedures were presented for appraising the ability of antibacterial chemicals and formulations to suppress the growth of microorganisms on human skin. In each of these, the microflora was quantified after the skin had been occlusively covered for a day or more, a circumstance which, in the absence of a deterre...

journal_title：Antimicrobial agents and chemotherapy

authors： Marples RR,Kligman AM

更新日期：1974-03-01 00:00:00

abstract：:Antibiotic dynamics in the fluid obtained from subcutaneously implanted chambers in rats were similar to those observed in serum following single intramuscular injections of carbenicillin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gardner WG,Prior RB,Perkins RL

更新日期：1973-08-01 00:00:00

abstract：:We used information available from routine clinic visits to characterize the pharmacokinetics of didanosine in 82 human immunodeficiency virus-infected patients. A total of 271 blood samples were collected for the measurement of didanosine concentrations in plasma (mean +/- standard deviation [SD], 3.30 +/- 2.21 sampl...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams JM,Shelton MJ,Hewitt RG,Grasela TH,DeRemer M,Morse GD

更新日期：1998-04-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Joanny F,Held J,Mordmüller B

更新日期：2012-11-01 00:00:00

abstract：:Linezolid was tested against 32 species of uncommonly isolated gram-positive organisms (3,251 strains) by reference MIC methods and found to be highly active (MIC50 range, 0.25 to 2 microg/ml; MIC90 range, 0.25 to 2 microg/ml). Only one isolate (viridans group streptococcus; 0.03% of tested strains) was resistant to l...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Stilwell MG,Hogan PA,Sheehan DJ

更新日期：2007-04-01 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:Win 41258-3 (4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1H-pyrazole methane sulfonate) has in vitro and in vivo activity against herpes simplex virus types 1 and 2. In cell culture, a concentration of 2 microgram/ml produced a greater than 50% inhibition of plaque formation of herpes simplex virus type 2, and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pancic F,Steinberg BA,Diana GD,Carabateas PM,Gorman WG,Came PE

更新日期：1981-03-01 00:00:00

abstract：:Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft DS

更新日期：1997-03-01 00:00:00

abstract：:The endoperoxides are a new class of antimalarial agents, of which artemisinin (qinghaosu) is the prototype. We have previously shown that artemisinin is capable of alkylating proteins in model reactions. In the present study, we showed that when Plasmodium falciparum-infected erythrocytes are treated with a radiolabe...

journal_title：Antimicrobial agents and chemotherapy

authors： Asawamahasakda W,Ittarat I,Pu YM,Ziffer H,Meshnick SR

更新日期：1994-08-01 00:00:00

abstract：:The in vitro activities of HMR 3647 (telithromycin) and HMR 3004, two novel semisynthetic ketolides, were investigated and compared with that of the reference macrolide drug, clarithromycin, against 34 strains of slowly growing mycobacteria at pHs 6.8 and 7.4, as determined radiometrically. The MICs at pH 7.4 were abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Goh KS,Berchel M,Bryskier A

更新日期：2000-10-01 00:00:00

abstract：:Gatifloxacin (GTX), a new fluoroquinolone with extended antibacterial activity, is an interesting candidate for the treatment of chronic bacterial prostatitis (CBP). Besides the antibacterial spectrum, the concentrations in the target tissues and fluids are crucial for the treatment of CBP. Thus, it was of interest to...

journal_title：Antimicrobial agents and chemotherapy

authors： Naber CK,Steghafner M,Kinzig-Schippers M,Sauber C,Sörgel F,Stahlberg HJ,Naber KG

更新日期：2001-01-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00