Abstract:
:Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Galluzzi L,Spranger S,Fuchs E,López-Soto Adoi
10.1016/j.tcb.2018.08.005subject
Has Abstractpub_date
2019-01-01 00:00:00pages
44-65issue
1eissn
0962-8924issn
1879-3088pii
S0962-8924(18)30143-0journal_volume
29pub_type
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