Abstract：
:Recent characterization of the major protein-targeting systems in both yeast and mammalian cells has provided detailed descriptions of how cellular transport processes operate. Increasingly, however, novel protein-sorting mechanisms are being uncovered. These newly discovered 'alternative' mechanisms of protein sorting ensure accurate delivery of numerous cellular constituents either to their resident compartment or, in many cases, to the cellular protein-degradation machinery. Like the better characterized 'classical' protein-sorting systems, 'nonclassical' targeting mechanisms involve both membrane translocation through protein channels and vesicle-mediated transport. This review discusses our current understanding of these nonclassical protein-sorting pathways and their role in eukaryotic cells.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Klionsky DJdoi
10.1016/S0962-8924(97)01050-7subject
Has Abstractpub_date
1997-06-01 00:00:00pages
225-9issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(97)01050-7journal_volume
7pub_type
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