Abstract：
:Long-distance cell-cell communication is essential for organ development and function. Whereas neurons communicate at long distances by transferring signals at sites of direct contact (i.e., at synapses), it has been presumed that the only way other cell types signal is by dispersing signals through extracellular fluid--indirectly. Recent evidence from Drosophila suggests that non-neuronal cells also exchange signaling proteins at sites of direct contact, even when long distances separate the cells. We review here contact-mediated signaling in neurons and discuss how this signaling mechanism is shared by other cell types.
journal_name
Trends Cell Bioljournal_title
Trends in cell biologyauthors
Kornberg TB,Roy Sdoi
10.1016/j.tcb.2014.01.003subject
Has Abstractpub_date
2014-06-01 00:00:00pages
370-6issue
6eissn
0962-8924issn
1879-3088pii
S0962-8924(14)00014-2journal_volume
24pub_type
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